Stearate-derived very long-chain fatty acids are indispensable to tumor growth [0.03%]
硬脂酸衍生的非常长链脂肪酸对肿瘤生长不可或缺
Qiaoyun Chu,Ping Liu,Yihan Song et al.
Qiaoyun Chu et al.
Published Erratum
The EMBO journal. 2023 Sep 4;42(17):e114802. DOI:10.15252/embj.2023114802 2023
The diverging role of CDC14B: from mitotic exit in yeast to cell fate control in humans [0.03%]
CDC14B的分化作用：从酵母中的有丝分裂退出到人类中的细胞命运决定
Patrick Partscht,Elmar Schiebel
Patrick Partscht
CDC14, originally identified as crucial mediator of mitotic exit in budding yeast, belongs to the family of dual-specificity phosphatases (DUSPs) that are present in most eukaryotes. Contradicting data have sparked a contentious discussion ...
microRNAs slow translating ribosomes to prevent protein misfolding in eukaryotes [0.03%]
微小核糖核酸通过减慢真核生物中核糖体的翻译速度来防止蛋白质错误折叠
Hiroaki Sako,Mohieldin Youssef,Olga Elisseeva et al.
Hiroaki Sako et al.
Slower translation rates reduce protein misfolding. Such reductions in speed can be mediated by the presence of non-optimal codons, which allow time for proper folding to occur. Although this phenomenon is conserved from bacteria to humans,...
Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity [0.03%]
DNA模板链中的未修复碱基切除修复中间体触发复制叉崩溃和PARP抑制剂敏感性
Almudena Serrano-Benitez,Sophie E Wells,Lylah Drummond-Clarke et al.
Almudena Serrano-Benitez et al.
DNA single-strand breaks (SSBs) disrupt DNA replication and induce chromosome breakage. However, whether SSBs induce chromosome breakage when present behind replication forks or ahead of replication forks is unclear. To address this questio...
Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket [0.03%]
甾体激素与人类ABCC3转运蛋白结合表明具有相容的两亲性底物结合袋
Jie Wang,Xu Li,Fang-Fang Wang et al.
Jie Wang et al.
The human ABC transporter ABCC3 (also known as MRP3) transports a wide spectrum of substrates, including endogenous metabolites and exogenous drugs. Accordingly, it participates in multiple physiological processes and is involved in diverse...
Direct observation of coordinated assembly of individual native centromeric nucleosomes [0.03%]
直接观察单个天然着丝粒核小体的协同装配过程
Andrew R Popchock,Joshua D Larson,Julien Dubrulle et al.
Andrew R Popchock et al.
Eukaryotic chromosome segregation requires the kinetochore, a megadalton-sized machine that forms on specialized centromeric chromatin containing CENP-A, a histone H3 variant. CENP-A deposition requires a chaperone protein HJURP that target...
Novel role of DONSON in CMG helicase assembly during vertebrate DNA replication initiation [0.03%]
DONSON在脊椎动物DNA复制起始过程中参与CMG解旋酶组装的新作用
Yoshitami Hashimoto,Kota Sadano,Nene Miyata et al.
Yoshitami Hashimoto et al.
CMG (Cdc45-MCM-GINS) helicase assembly at the replication origin is the culmination of eukaryotic DNA replication initiation. This process can be reconstructed in vitro using defined factors in Saccharomyces cerevisiae; however, in vertebra...
Cryo-EM structure of antibacterial efflux transporter QacA from Staphylococcus aureus reveals a novel extracellular loop with allosteric role [0.03%]
来自金黄色葡萄球菌的抗菌剂外排转运蛋白QacA的冷冻电镜结构揭示了一个具有别构作用的新胞外环
Puja Majumder,Shahbaz Ahmed,Pragya Ahuja et al.
Puja Majumder et al.
Efflux of antibacterial compounds is a major mechanism for developing antimicrobial resistance. In the Gram-positive pathogen Staphylococcus aureus, QacA, a 14 transmembrane helix containing major facilitator superfamily antiporter, mediate...
Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression [0.03%]
NME6介导的核糖核苷酸合成促进线粒体基因表达
Nils Grotehans,Lynn McGarry,Hendrik Nolte et al.
Nils Grotehans et al.
Replication of the mitochondrial genome and expression of the genes it encodes both depend on a sufficient supply of nucleotides to mitochondria. Accordingly, dysregulated nucleotide metabolism not only destabilises the mitochondrial genome...
A tale of two inhibitors: diarylquinolines and squaramides [0.03%]
双抑制剂的故事： Diarylquinolines和Squaramides的研究
James Chen,Damian C Ekiert
James Chen
The diarylquinoline bedaquiline (BDQ) is an FDA-approved drug for the treatment of multidrug-resistant tuberculosis that targets the mycobacterial adenosine triphosphate (ATP) synthase, a key enzyme in cellular respiration. In a recent stud...