Genistin: A Novel Estrogen Analogue Targeting ERβ to Alleviate Thrombocytopenia [0.03%]
.genistin：一种新型雌激素类似物，作用于ERβ以缓解血小板减少症
Xiaoqin Tang,Rui Liao,Ling Zhou et al.
Xiaoqin Tang et al.
Thrombocytopenia, a prevalent hematologic challenge, correlates directly with the mortality of numerous ailments. Current therapeutic avenues for thrombocytopenia are not without limitations. Here, we identify genistin, an estrogen analogue...
TIE1 promotes cervical cancer progression via Basigin-matrix metalloproteinase axis [0.03%]
TIE1通过Basigin-基质金属蛋白酶轴促进宫颈癌进展
Pan Liu,Lisha Xie,Qiulei Wu et al.
Pan Liu et al.
Background: Tyrosine kinase with immunoglobulin and EGF-like domains 1 (TIE1) is known as an orphan receptor prominently expressed in endothelial cells and participates in angiogenesis by regulating TIE2 activity. Our previous study demonst...
Deficiency of Cbfβ in articular cartilage leads to osteoarthritis-like phenotype through Hippo/Yap, TGFβ, and Wnt/β-catenin signaling pathways [0.03%]
Cbfβ关节软骨缺陷通过Hippo/Yap，TGFβ和Wnt/β-连环蛋白信号通路导致类骨性关节炎表型
Yan Zhang,Huiwen Chen,Jinjin Wu et al.
Yan Zhang et al.
Osteoarthritis (OA) is the most prevalent degenerative joint disorder, causing physical impairments among the elderly. Core binding factor subunit β (Cbfβ) has a critical role in bone homeostasis and cartilage development. However, the fu...
Erratum: Linc-KILH potentiates Notch1 signaling through inhibiting KRT19 phosphorylation and promotes the malignancy of hepatocellular carcinoma: Erratum [0.03%]
长链非编码RNA Linc-KILH通过抑制角蛋白KRT19磷酸化促进诺尔特希1信号转导并促进肝细胞癌恶性进展：勘误启事
Xudong Zhang,Xiaoliang Xu,Zechuan Zhang et al.
Xudong Zhang et al.
[This corrects the article DOI: 10.7150/ijbs.52279.]. © The author(s).
NUP85 alleviates lipid metabolism and inflammation by regulating PI3K/AKT signaling pathway in nonalcoholic fatty liver disease [0.03%]
NUP85通过调节PI3K / AKT信号通路缓解非酒精性脂肪肝病中的脂质代谢和炎症反应
Yin-Cui Wu,Qi Yan,Si-Qing Yue et al.
Yin-Cui Wu et al.
Nonalcoholic fatty liver disease (NAFLD) is one of the common causes of chronic liver disease in the world. The problem of NAFLD had become increasingly prominent. However, its pathogenesis is still indistinct. As we all know, NAFLD begins ...
Dysregulated Ribosome Biogenesis Is a Targetable Vulnerability in Triple-Negative Breast Cancer: MRPS27 as a Key Mediator of the Stemness-inhibitory Effect of Lovastatin [0.03%]
核糖体生物合成失调是三阴性乳腺癌的可靶向弱点：MRPS27作为Lovastatin抑制肿瘤干细胞作用的关键介导因子
Chanjuan Zheng,Hui Yao,Lu Lu et al.
Chanjuan Zheng et al.
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with limited effective therapeutic options readily available. We have previously demonstrated that lovastatin, an FDA-approved lipid-lowering drug, selecti...
Myeloid-derived Wnts play an indispensible role in macrophage and fibroblast activation and kidney fibrosis [0.03%]
髓系来源的Wnt在巨噬细胞和成纤维细胞活化及肾纤维化中起不可或缺作用
Yuan Tian,Jiongcheng Chen,Wenshu Huang et al.
Yuan Tian et al.
Wnt/β-catenin signaling plays a pivotal role in the pathogenesis of chronic kidney diseases (CKD), which is associated with macrophage activation and polarization. However, the relative contribution of macrophage-derived Wnts in the evolut...
Erratum: Activation of Nrf2 Attenuates Pulmonary Vascular Remodeling via Inhibiting Endothelial-to-Mesenchymal Transition: an Insight from a Plant Polyphenol: Erratum [0.03%]
Nrf2激活通过抑制内皮-间充质转化来减轻肺血管重塑的机制研究：一种植物多酚提供的新视角：勘误表
Yucai Chen,Tianyi Yuan,Huifang Zhang et al.
Yucai Chen et al.
[This corrects the article DOI: 10.7150/ijbs.20316.]. © The author(s).
Colchicine Blocks Abdominal Aortic Aneurysm Development by Maintaining Vascular Smooth Muscle Cell Homeostasis [0.03%]
秋水仙素通过维持血管平滑肌细胞稳态来阻断腹主动脉瘤的发展
Min Chen,Dafeng Yang,Yangzhao Zhou et al.
Min Chen et al.
Development of non-surgical treatment of human abdominal aortic aneurysm (AAA) has clinical significance. Colchicine emerges as an effective therapeutic regimen in cardiovascular diseases. Yet, whether colchicine slows AAA growth remain con...
Xin Yu,Wenge Li,Zhi Li et al.
Xin Yu et al.
The role of the microbiome in immunotherapy has recently garnered substantial attention, with molecular studies and clinical trials providing emerging evidence on the pivotal influence of the microbiota in enhancing therapeutic outcomes via...