Olfactomedin-4 deletion exacerbates DSS-induced colitis through a matrix metalloproteinase-9-dependent mechanism [0.03%]
嗅素介导蛋白-4通过基质金属蛋白酶-9依赖性机制促进葡聚糖硫酸钠诱导的结肠炎的发展恶化
Xinyu Wang,Shenghui Chen,Jinghua Wang et al.
Xinyu Wang et al.
Background and Aims: Olfactomedin-4 is a glycoprotein that is upregulated in inflamed gastrointestinal tissues. This study aimed to investigate the role and underlying mechanisms of olfactomedin-4 in ulcerative colitis. Methods: C57BL/6 mic...
Exploration of spatial heterogeneity of tumor microenvironment in nasopharyngeal carcinoma via transcriptional digital spatial profiling [0.03%]
基于转录组的空间分子位置解析技术探索鼻咽癌微环境空间异质性
Liping Wang,Dujuan Wang,Xiaojiao Zeng et al.
Liping Wang et al.
The heterogeneity of nasopharyngeal carcinoma (NPC) leads to mixed clinical outcomes. We collected 92 regions of interest from 41 biopsies of patients with untreated NPC and obtained their transcripts using GeoMx Digital Spatial Profiling (...
S100 Calcium Binding Protein A16 Promotes Cell Proliferation by triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development [0.03%]
钙结合蛋白A16通过诱导CUL4A泛素连接酶介导的LATS1降解在胶质瘤发生中抑制Hippo通路从而促进细胞增殖
Yifang Hu,Rihua Zhang,Shan Lu et al.
Yifang Hu et al.
Background: S100 Calcium Binding Protein A16 (S100A16), a novel member of S100 protein family, is linked to tumorigenic processes and abundantly expressed in CNS tissues. Our study aimed to explore the biological function and possible mecha...
Gli1 promotes the phenotypic transformation of valve interstitial cells through Hedgehog pathway activation exacerbating calcific aortic valve disease [0.03%]
Gli1通过激活Hedgehog途径促进瓣间细胞表型转化加重钙化性主动脉瓣病
Yuming Huang,Chen Jiang,Liang Chen et al.
Yuming Huang et al.
Calcific aortic valve disease (CAVD) is the most prevalent human valve disease worldwide. Multiple factors induce "irreversible" pathological changes in the aortic valve leaflets, resulting in changes in cardiac hemodynamics, eventually lea...
Bulk and single-cell transcriptome profiling reveal extracellular matrix mechanical regulation of lipid metabolism reprograming through YAP/TEAD4/ACADL axis in hepatocellular carcinoma [0.03%]
单细胞及总体转录组分析揭示YAP/TEAD4/ACADL轴介导的肝癌脂代谢重编程的新机制
Jingwei Cai,Tianyi Chen,Zhiyu Jiang et al.
Jingwei Cai et al.
Emerging studies have revealed matrix stiffness promotes hepatocellular carcinoma (HCC) development. We studied metabolic dysregulation in HCC using the TCGA-LIHC database (n=374) and GEO datasets (GSE14520). HCC samples were classified int...
Cytochalasin D restores nuclear size acting on F-actin and IZUMO1 localization in low-quality spermatozoa [0.03%]
细胞松弛素D通过作用于F-肌动蛋白和IZUMO1定位恢复低质量精子的核大小
Guillaume Martinez,Donato Cappetta,Marialucia Telesca et al.
Guillaume Martinez et al.
In spermatozoa, the nuclear F-actin supports the acroplaxome, a subacrosomal structure involved in the correct exposure of several acrosomal membrane proteins; among them, the glycoprotein IZUMO1 is the major protein involved in sperm-oocyt...
Metabolic modulation of CtBP dimeric status impacts the repression of DNA damage repair genes and the platinum sensitivity of ovarian cancer [0.03%]
CTBP二聚体状态的代谢调控影响卵巢癌DNA损伤修复基因的抑制和铂敏感性
Jingjing Li,Yuan Wang,Li Wang et al.
Jingjing Li et al.
Platinum drug-based chemotherapy plays a dominant role in OC (ovarian cancer) treatment. The expression of DNA damage repair (DDR) genes is critical in distinguishing drug-sensitive and drug-refractory patients, as well as in the developmen...
Berberine inhibits high fat diet-associated colorectal cancer through modulation of the gut microbiota-mediated lysophosphatidylcholine [0.03%]
番红花素通过调节肠道菌群介导的溶血磷脂酰胆碱抑制高脂肪饮食相关的结直肠癌
Haitao Chen,Chenxiao Ye,Changhong Wu et al.
Haitao Chen et al.
Dietary fat intake is positively associated with elevated risk of colorectal cancer (CRC). Currently, clinical treatments remian inadequate bacause of the complex pathogenesis of CRC induced by a high-fat diet (HFD). Mechanistically, imbala...
CTSG Suppresses Colorectal Cancer Progression through Negative Regulation of Akt/mTOR/Bcl2 Signaling Pathway [0.03%]
CTSG通过抑制Akt/mTOR/Bcl2信号通路来抑制结直肠癌进展
Shixin Chan,Xu Wang,Zhenglin Wang et al.
Shixin Chan et al.
Colorectal cancer (CRC) is the most common gastrointestinal tumor worldwide, which is a severe malignant disease that threatens mankind. Cathepsin G (CTSG) has been reported to be associated with tumorigenesis, whereas its role in CRC is st...
Application of single-cell RNA sequencing on human testicular samples: a comprehensive review [0.03%]
单细胞RNA测序在人类睾丸样本中的应用：全面综述
Fan Dong,Ping Ping,Yi Ma et al.
Fan Dong et al.
So far there has been no comprehensive review using systematic literature search strategies to show the application of single-cell RNA sequencing (scRNA-seq) in the human testis of the whole life cycle (from embryos to aging males). Here, w...