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Myeloid-derived Wnts play an indispensible role in macrophage and fibroblast activation and kidney fibrosis

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Wnt/β-catenin signaling plays a pivotal role in the pathogenesis of chronic kidney diseases (CKD), which is associated with macrophage activation and polarization. However, the relative contribution of macrophage-derived Wnts in the evolution of CKD is poorly... ...