Establishment and evaluation of retroperitoneal liposarcoma patient-derived xenograft models: an ideal model for preclinical study [0.03%]
腹膜后脂肪肉瘤患者来源异种移植瘤模型的建立及评价：理想的临床前研究模型
Chang Xu,Liang Yan,Qiming An et al.
Chang Xu et al.
Retroperitoneal liposarcoma (RLPS) is one of the most common subtypes of retroperitoneal soft tissue sarcomas. It is characterized by poor sensitivity to radiotherapy and chemotherapy and a low success rate of complete surgical resection. H...
A proprietary blend of standardized Punica granatum fruit rind and Theobroma cocoa seed extracts mitigates aging males' symptoms: A randomized, double-blind, placebo-controlled study [0.03%]
番石榴果皮和可可种子提取物复合成分改善男性衰老症状：随机双盲安慰剂对照试验
Sucharitha L Pandit,Dayanand Yaligar,Manjunath Halemane et al.
Sucharitha L Pandit et al.
Objective: We evaluated the safety and efficacy of a novel combination of Punica granatum fruit rind and Theobroma cocoa seed extracts (LN18178 or Tesnor®) in enhancing serum testosterone level and reducing aging males' symptoms (AMS) in a...
Randomized Controlled Trial
International journal of medical sciences. 2022 Jul 11;19(8):1290-1299. DOI:10.7150/ijms.73645 2022
Exosomes with FOXP3 from gene-modified dendritic cells ameliorate the development of EAE by regulating the balance of Th/Treg [0.03%]
基因修饰的树突细胞分泌的FOXP3阳性外泌体通过调节Th/Treg平衡改善EAE发展
Zhen Jia,Jia Liu,Bin Li et al.
Zhen Jia et al.
Objective: To investigate the efficiency and potential mechanisms of exosomes from dendritic cells (DCs) transfected with Forkhead box protein P3 (FOXP3) in the development of experimental autoimmune encephalomyelitis (EAE). Method: Mouse b...
Light Emitting Diodes Irradiation Regulates miRNA-877-3p to Promote Cardiomyocyte Proliferation [0.03%]
光照通过调节miRNA-877-3p促进心肌细胞增殖
Xinlu Gao,Hanjing Li,Xiuxiu Wang et al.
Xinlu Gao et al.
Mammalian cardiomyocytes (CMs) maintain a low capacity for self-renewal in adulthood, therefore the induction of CMs cycle re-entry is an important approach to promote myocardial repair after injury. Recently, photobiomodulation (PBM) has b...
Qifan Yang,Jing Liu,Bo Wu et al.
Qifan Yang et al.
Osteosarcoma is a malignant bone tumor characterized by the direct production of osteoid tissue from tumor cells. Extracellular vesicles are membranous vesicles released by cells into the extracellular matrix, which exist widely in various ...
Identification and validation of MicroRNA-mRNA Networks in Dorsal Root Ganglia after Peripheral Nerve Injury [0.03%]
外周神经损伤后脊髓背根节中微小核糖核酸-信使核糖核酸网络的鉴定与验证
Xinyi Gu,Hao Guo,Canjun Zeng et al.
Xinyi Gu et al.
Changes in DRG after nerve injury involve neuronal damage, apoptosis, pain transmission, and activation of regenerative programs. It is unclear which genes and microRNAs may play a major role in this process. Therefore, this study performed...
Research Progress in the Medical Application of Heavy Water, Especially in the Field of D2O-Raman Spectroscopy [0.03%]
重水的医学研究进展及D2O拉曼光谱学领域的应用特色分析
Xin Wang,Nai-Meng Liu,Ya-Fei Zhao et al.
Xin Wang et al.
Heavy water is an ideal contrast agent for metabolic activity and can be adapted to a wide range of biological systems owing to its non-invasiveness, universal applicability, and cost-effectiveness. As a new type of probe, the heavy isotope...
LIM Mineralization Protein-1 Enhances the Committed Differentiation of Dental Pulp Stem Cells through the ERK1/2 and p38 MAPK Pathways and BMP Signaling [0.03%]
矿化蛋白-1通过ERK1 / 2和p38 MAPK途径及BMP信号促进牙髓干细胞定向分化
Rui Mu,Bo Chen,Bo Bi et al.
Rui Mu et al.
Tissue regeneration is the preferred treatment for dentin and bone tissue defects. Dental pulp stem cells (DPSCs) have been extensively studied for their use in tissue regeneration, including the regeneration of dentin and bone tissue. LIM ...
Raddeanin A (RA) reduced acute inflammatory injury in mouse experimental cerebral hemorrhage by suppression of TLR4 [0.03%]
拉达迪因A通过抑制TLR4减少急性炎症损伤及鼠实验性脑出血
Bo Hei,Jia Ouyang,Jingru Zhou et al.
Bo Hei et al.
Spontaneous intracerebral hemorrhage (ICH) is associated with high mortality and disability rates. The microglia-induced inflammatory response is a critical factor determining brain tissue damage after ICH. Raddeanin A (RA) is a natural tri...
MALAT1 Polymorphisms and Lung Cancer Susceptibility in a Chinese Northeast Han Population [0.03%]
中国东北汉族人中MALAT1基因多态性与肺癌易感性的关联研究
Guanghui Tong,Weiwei Tong,Ran He et al.
Guanghui Tong et al.
Background: LncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) was competitive endogenous RNA (ceRNA) involved in various molecular processes for metastasis development in lung cancer. Single nucleotide polymorphisms (SN...