Green tea containing inulin and catechins ameliorates high-fat diet-induced metabolic dysfunction-associated fatty liver disease in mice [0.03%]
含低聚糖和儿茶素的绿茶改善高脂饮食诱导的小鼠代谢紊乱相关性脂肪肝病
Yu-Hao Lee,Chi-Chang Huang,Hung-Lung Lin et al.
Yu-Hao Lee et al.
The global rise in obesity has contributed to the increasing prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD, formerly known as non-alcoholic fatty liver disease, NAFLD), which is strongly linked to insulin resista...
Machine Learning-Based WGCNA Approach for Developing an Immunogenic Cell Death-Related Hub Gene Signature and Identification of AJM1 as a Prognostic Biomarker in Pancreatic Adenocarcinoma [0.03%]
基于机器学习的WGCNA方法开发与免疫源性细胞死亡相关的基因特征并鉴定AJM1作为胰腺导管腺癌预后生物标志物
Tianyin Ma,Xiangdong Gongye,Cairang Dongzhi et al.
Tianyin Ma et al.
Background & Aims: Pancreatic adenocarcinoma (PAAD) remains a highly lethal malignancy with limited therapeutic options, primarily due to the absence of reliable prognostic biomarkers. Immunogenic cell death (ICD) plays a pivotal role in an...
Synergistic increase in anti-cancer stemness activity and pro-apoptotic effects in human glioblastoma cancer stem-like cells by combination treatment with temozolomide and corosolic acid [0.03%]
白杨酸与替莫唑胺联合治疗人胶质母细胞瘤癌干细胞样细胞的协同增效作用
Chuan-Yi Kao,Hsiang-Yao Shih,Yi-Hsien Hsieh et al.
Chuan-Yi Kao et al.
Glioblastoma (GB) is a highly aggressive brain cancer with poor prognosis and a five-year survival rate of only 4-5%, largely due to challenges in surgical removal and radiotherapy limitations. Corosolic acid (CA), a natural pentacyclic tri...
Comprehensive Analysis of Aberrant m6A RNA Modifications Identifies Prognostic Biomarkers in Non-Small Cell Lung Cancer [0.03%]
全面分析非小细胞肺癌中异常的m6A RNA修饰以识别预后生物标志物
Yifei Li,Peng Jiao,Donghang Li et al.
Yifei Li et al.
Background: Dysregulation of N6-methyladenosine (m6A) RNA modification plays a critical role in the development and progression of non-small cell lung cancer (NSCLC). Methods: To explore the m6A modification landscape in NSCLC, we utilized ...
Molecular mechanisms and biomarkers of total parenteral nutrition-induced hepatotoxicity revealed by iTRAQ proteomics analysis [0.03%]
iTRAQ蛋白质组学分析揭示全肠外营养诱导的肝毒性的分子机制与生物标志物
Yung-Yu Hsieh,Jai-Jen Tsai,Shui-Yi Tung et al.
Yung-Yu Hsieh et al.
Background/Aims: Total parenteral nutrition (TPN) provides medical nutrients intravenously to patients who cannot obtain proper nutrition through normal dietary means or enteral feeding. One significant concern is the risk of liver damage a...
Impact of Subcutaneous Adipose Tissue Index Change During Neoadjuvant Chemoradiotherapy on Disease-Free Survival and Tumor Response in Patients with Locally Advanced Rectal Cancer [0.03%]
新辅助化放疗期间皮下脂肪组织指数变化对局部晚期直肠癌患者无病生存率及肿瘤应答的影响
Qing Yang,Siyi Lu,Ruize Qu et al.
Qing Yang et al.
Background & Aims: The heterogeneity among patients with locally advanced rectal cancer (LARC) necessitates identifying predictive markers of response to neoadjuvant chemoradiotherapy (nCRT) to enable personalized treatment strategies. Adip...
Tricin inhibits the migration of human retinal pigment epithelium cells by suppressing the RUNX2-CYP1A1 axis and STAT3 pathway [0.03%]
芦丁通过抑制RUNX2-CYP1A1轴和STAT3通路来抑制人视网膜色素上皮细胞迁移作用
Wei-Yang Lu,I-Chia Liang,Yi-Hsien Hsieh et al.
Wei-Yang Lu et al.
Proliferative vitreoretinopathy (PVR) is a retinal disorder characterized by abnormal growth and migration of retinal pigment epithelium (RPE) cells, leading to impaired visual acuity. Tricin is a naturally occurring flavone known to inhibi...
The impact of evodiamine on human anaplastic thyroid cancer therapy-an in vitro and in vivo study [0.03%]
吴茱萸碱对人类甲状腺癌的治疗作用及机制研究
Yin-Che Lu,Tsung-Hsing Lin,Kai-Liang Tang et al.
Yin-Che Lu et al.
Thyroid cancer (TC) is the most common endocrine malignancy, with anaplastic thyroid cancer (ATC) being the most aggressive subtype. Evodiamine (EVO), a bioactive compound derived from Evodia rutaecarpa, possesses anti-inflammatory and anti...
Mapping the Somatic Mutation Landscape of Familial NF2-Related Schwannomatosis using Whole-Exome Sequencing [0.03%]
全外显子组测序绘制NF2相关家族 schwannomatosis的体细胞突变图谱
Fushu Luo,Liangqi Jiang,Yimin Pan et al.
Fushu Luo et al.
Background: Neurofibromatosis type 2 (NF2), currently more accurately named NF2-related schwannomatosis (NF2-SWN), is classified as a multiple tumor syndrome, caused by impaired expression of the merlin protein. Approximately 50% of affecte...
Clostridium butyricum GKB7 increase Physical Performance and Improve Biochemistry Profile on Mice with Inherently Low Aerobic Capacity [0.03%]
枯草丁酸菌GKB7改善低有氧运动能力小鼠的体能和生化指标
Mon-Chien Lee,Chao-Yuan Chen,Yi-Ju Hsu et al.
Mon-Chien Lee et al.
Introduction: This study investigates the effects of Clostridium butyricum GKB7 (CB), a product manufactured by Grape King Bio Ltd., on enhancing exercise performance and blood biochemistry in mice with intrinsically low aerobic exercise ca...