Inhibition of YAP Sensitizes the Selumetinib Treatment for Neurofibromatosis Type 1 Related Plexiform Neurofibroma [0.03%]
YAP的抑制使塞洛米替尼对神经纤维瘤病Ⅰ型相关plexiform神经纤维瘤的治疗更加敏感
Zhuowei Tian,Yuanhe You,Meng Xiao et al.
Zhuowei Tian et al.
Background: Targeted therapy of Neurofibromatosis type 1 (NF1) related plexiform neurofibroma (pNF) aiming at MEK molecule has not demonstrated a convincing result for complete disease inhibition, probably due to other signal pathways cross...
EZH2 promotes angiogenesis in peritoneal dialysis by epigenetically activating SP4 expression in the IL-6/sIL-6R signalling pathway [0.03%]
EZH2通过表观遗传激活IL-6/sIL-6R信号通路中的SP4表达来促进腹膜透析中的血管生成
Nan Zhu,Haochen Guan,Xuan Wang et al.
Nan Zhu et al.
Background: Interleukin-6 (IL-6)/soluble IL-6 receptor (sIL-6R) promotes peritoneal angiogenesis by stimulating SP4-mediated vascular endothelial growth factor (VEGF) production in peritoneal dialysis (PD). Moreover, histone methyltransfera...
Artificial intelligence in clinical decision support systems for oncology [0.03%]
用于肿瘤临床决策支持系统的人工智能技术
Lu Wang,Xinyi Chen,Lu Zhang et al.
Lu Wang et al.
Artificial intelligence (AI) has been widely used in various medical fields, such as image diagnosis, pathological classification, selection of treatment schemes, and prognosis analysis. Especially in the image-aided diagnosis of tumors, th...
TRPM2 facilitates tumor progression of clear cell renal cell carcinoma by relieving Endoplasmic Reticulum Stress [0.03%]
TRPM2通过缓解内质网应激促进透明细胞肾细胞癌的肿瘤进展
Hongwei Yuan,Weiquan Li,Ning Lou et al.
Hongwei Yuan et al.
Clear cell renal cell carcinoma (ccRCC) has the highest incidence rate among all pathological types of kidney cancers. Although the role of transient receptor potential (TRP) ion channel TRPM2 has been studied in many cancers, its function ...
USP44 accelerates the growth of T-cell acute lymphoblastic leukemia through interacting with WDR5 and repressing its ubiquitination [0.03%]
USP44通过与WDR5相互作用并抑制其泛素化来加速T细胞急性淋巴性白血病的生长
Zuofei Chi,Bin Zhang,Ruowen Sun et al.
Zuofei Chi et al.
T-cell acute lymphoblastic leukemia (T-ALL) is a common hematologic malignancy. Based on the data from GSE66638 and GSE141140, T-ALL patients depicted a higher USP44 level. However, its role in T-ALL is still unclear. In the present study, ...
Prognostic value of pretreatment systemic inflammatory markers in patients with stage I endometrial cancer [0.03%]
术前全身炎症标志物对I期子宫内膜癌患者预后的评估价值
Jung Hwan Ahn,Sung Jong Lee,Joo Hee Yoon et al.
Jung Hwan Ahn et al.
Objective: Evaluate the prognostic value of monocyte-lymphocyte ratio (MLR) in patients with stage I endometrial cancer. Method: Data from 225 patients with stage I endometrioid endometrial cancer who underwent surgical resection between Ja...
Anticancer peptide Q7 suppresses the growth and migration of human endometrial cancer by inhibiting DHCR24 expression and modulating the AKT-mediated pathway [0.03%]
抗癌肽Q7通过抑制DHCR24表达和调节AKT介导的途径来抑制人子宫内膜癌的生长和迁移
Chia-Hung Chen,Tzu-Hsiang Weng,Kai-Yao Huang et al.
Chia-Hung Chen et al.
Endometrial cancer is one of the most common malignancy affecting women in developed countries. Resection uterus or lesion area is usually the first option for a simple and efficient therapy. Therefore, it is necessary to find a new therape...
High-mobility Group Box 1 Contributes to Hypoxic-Ischemic Brain Damage by Facilitating Imbalance of Microglial Polarization through RAGE-PI3K/Akt Pathway in Neonatal Rats [0.03%]
高迁移率族盒1通过RAGE-PI3K/Akt通路促进微胶质细胞极化失衡导致新生大鼠缺氧缺血性脑损伤
Yanyan Sun,Xing Zhu,Kaiyi Zhu et al.
Yanyan Sun et al.
High mobility group box 1 (HMGB1) is a damage-associated molecular pattern integral for hypoxic-ischemic brain damage (HIBD) in neonatal rats since it regulates the phenotypic polarization of microglia, as depicted in our previous studies. ...
Xinyu Qiao,Wei Zhang,Weijiang Zhao
Xinyu Qiao
Spinal cord injury (SCI) results in acute inflammatory responses and secondary damages, including neuronal and glial cell death, axonal damage and demyelination, and blood-brain barrier (BBB) damage, eventually leading to neuronal dysfuncti...
Blockade of SK4 channels suppresses atrial fibrillation by attenuating atrial fibrosis in canines with prolonged atrial pacing [0.03%]
阻断SK4通道通过减弱犬类长期心房起搏的纤维化来抑制心房颤动
Youcheng Wang,Yajun Yao,Yazhe Ma et al.
Youcheng Wang et al.
Background: We previously found that intermediate conductance Ca2+-activated K+ channel (SK4) might be an important target in atrial fibrillation (AF). Objective: To investigate the role of SK4 in AF maintenance. Methods: Twenty beagles wer...