Qingwen Yang,Lingying Ye,Jiasheng Liu et al.
Qingwen Yang et al.
This study aimed to investigate the capsule-epithelium-fibre unit ultrastructure of the human lens, particularly the interfaces of the epithelium with the capsule and the epithelium with the fibre cell. A total of 12 lenses from donor human...
Increased Pro Th1 And Th17 Transcriptional Activity In Patients With Severe COVID-19 [0.03%]
重症COVID-19患者中促Th1和Th17的转录活性增强
Marina Jovanovic,Sofija Sekulic,Miodrag Jocic et al.
Marina Jovanovic et al.
Background: COVID-19 is known to disrupt immune response and induce hyperinflammation that could potentially induce fatal outcome of the disease. Until now, it is known that interplay among cytokines is rather important for clinical present...
Activating SIRT1 deacetylates NF-κB p65 to alleviate liver inflammation and fibrosis via inhibiting NLRP3 pathway in macrophages [0.03%]
激活SIRT1通过去乙酰化NF-κB p65来抑制巨噬细胞的NLRP3途径从而缓解肝炎和纤维化
Shuli He,Yaru Wang,Jinying Liu et al.
Shuli He et al.
Background and aims: Macrophages play a critical role in the development of liver diseases. As an NAD+-dependent histone deacetylase, SIRT1 inhibits liver inflammation and fibrosis, but the mechanisms are not fully understood. Our aim was t...
Smoking and Unstable Plaque in Acute Coronary Syndrome: A Systematic Review of The Role of Matrix Metalloproteinases [0.03%]
吸烟与急性冠脉综合症斑块不稳定的金属基质金属蛋白酶作用系统评价
Amilia Aminuddin,Siao Suan Cheong,Nur Aishah Che Roos et al.
Amilia Aminuddin et al.
Smoking is a risk factor of acute coronary syndrome (ACS) that could increase matrix metalloproteinases (MMPs) levels, leading to unstable coronary artery plaque. The current review aimed to identify the relationship between smoking and MMP...
Jinming Huang,Yi Li,Siyi Zhu et al.
Jinming Huang et al.
Bone and joint diseases are a group of clinically heterogeneous diseases characterized by various bone strength disorders, bone structural defects and bone mass abnormalities. Common bone diseases include osteoporosis, skeletal dysplasia, a...
ZNF460-regulated COMMD7 Promotes Acute Myeloid Leukemia Proliferation Via the NF-κB Signaling Pathway [0.03%]
锌指蛋白ZNF460通过调控COMMD7促进急性髓系白血病增殖的机制研究
Xin Shao,Liang Zhong,Xuan Chu et al.
Xin Shao et al.
Acute myeloid leukemia (AML) is a malignancy of the hematological system, for which there remains an urgent need for new therapeutic and diagnostic targets. COMM domain containing 7 (COMMD7) is a recently-identified oncogene linked to poor ...
P66Shc is increased in peripheral blood mononuclear cells of the patients with obstructive sleep apnea [0.03%]
阻塞性睡眠呼吸暂停患者外周血单个核细胞中P66Shc蛋白表达增加
Xing Lyu,Jingyao Cai,Rongxuan Yan et al.
Xing Lyu et al.
Objective: Obstructive sleep apnea (OSA) is characterized by nocturnal intermittent hypoxemia and linked to oxidative stress. Evidence demonstrated that p66Shc plays a key role in regulating oxidative stress. This study aimed to investigate...
FAT10 Silencing Prevents Liver Fibrosis through Regulating SIRT1 Expression in Hepatic Stellate Cells [0.03%]
沉默FAT10通过调节SIRT1表达抑制肝星状细胞活化从而防止肝纤维化
Weihong Zheng,Fei Guan,Guoxing Xu et al.
Weihong Zheng et al.
Background and objectives: Hepatic stellate cell (HSC) activation is the cardinal factor due to the accumulation of extracellular matrix proteins during the development of liver fibrosis. The aim of the present study was to find new targets...
Endothelial progenitor cell derived exosomes mediated miR-182-5p delivery accelerate diabetic wound healing via down-regulating PPARG [0.03%]
内皮祖细胞来源的外泌体递送的miR-182-5p通过下调PPARG促进糖尿病伤口愈合
Peng Li,Guanhao Hong,Weiqiang Zhan et al.
Peng Li et al.
Diabetic wound is one of the most common and serious complications of diabetes, which is characterized by abnormal number and quality of wound repair related cells. Previous studies have shown that human endothelial progenitor cells derived...
Is there a relationship between surgical proficiency and oncologic outcome of minimally invasive radical hysterectomy for early-stage cervical cancer? [0.03%]
微创根治性子宫切除术治疗早期宫颈癌的手术熟练度与肿瘤学结局的关系探讨
Jung Hwan Ahn,Jisu Yun,Chae Young Yun et al.
Jung Hwan Ahn et al.
Objective: Investigate the relationship between surgical proficiency and oncological outcomes of minimally invasive surgery (MIS) in the treatment of early-stage cervical cancer. Methods: This retrospective study included patients with cerv...