Histone H3 activates caspase-1 and promotes proliferation and metastasis in hepatocellular carcinoma [0.03%]
组蛋白H3通过激活半胱天冬酶-1促进肝癌增殖和转移
Mengjia Jing,Lamu Qiong,Zi Wang et al.
Mengjia Jing et al.
Background: As a component of nucleosomes, histone H3 plays an important role in chromosome structure and gene expression. Current studies have mostly focused on the role of histones in epigenetics, but in addition to this, the role of hist...
Renalase Prevents Renal Fibrosis by Inhibiting Endoplasmic Reticulum Stress and Down-Regulating GSK-3β/Snail Signaling [0.03%]
肾纤维化抑制剂renalase通过抑制内质网应激和下调GSK-3β/Snail信号通路发挥作用
Yiru Wu,Yu Bai,Yiduo Feng et al.
Yiru Wu et al.
Background: Treating renal fibrosis is crucial to delaying chronic kidney disease. The glycogen synthase kinase-3β (GSK-3β)/Snail pathway regulates renal fibrosis and Renalase can ameliorate renal interstitial fibrosis. However, it is not...
Dysfunction of circulating CD3+CD56+ NKT-like cells in type 2 diabetes mellitus [0.03%]
2型糖尿病患者外周血来源的CD3⁺CD56⁺NKT样细胞功能异常
Ling Tang,Hui Wang,Kangli Cao et al.
Ling Tang et al.
Type 2 diabetes mellitus (T2DM) is associated with increased incidence and mortality of many cancers and infectious diseases. CD3+CD56+ NKT-like cells play pivotal roles in tumor surveillance and infection control. However, little is known ...
USP14 promotes the malignant progression and ibrutinib resistance of mantle cell lymphoma by stabilizing XPO1 [0.03%]
USP14通过稳定XPO1促进套细胞淋巴瘤的恶性进展和伊布替尼耐药性
Ye Zhang,Peng Lu,Shenhe Jin et al.
Ye Zhang et al.
Background: Mantle cell lymphoma (MCL) is a heterogeneous disease belonging to non-Hodgkin's lymphoma. In recent years, the morbidity rate of MCL is ascending, and the prognosis remains unfavorable. Ubiquitin-specific proteases14 (USP14) ha...
Prognostic Value of Serum Albumin in Aortic Aneurysm Patients Undergoing Graft Replacement of Ascending Aorta and Aortic Arch [0.03%]
升主动脉和主动脉弓置换术患者的血清白蛋白预后价值
Won Seok Nam,Myung Il Bae,Sang Beom Nam et al.
Won Seok Nam et al.
Background: Hypoalbuminemia is a marker of poor overall health with influences from protein energy malnutrition, systemic inflammation and hepatic and renal disease. Albumin has been reported to have a prognostic impact in various cohorts. ...
Comparative in vitro study on biomechanical behavior of zirconia and polyetheretherketone biomaterials exposed to experimental loading conditions in a prototypal simulator [0.03%]
一种体外模拟加载实验条件下评价锆瓷和聚醚醚酮生物力学性能的对比研究
Vincenzo Vertucci,Benedetta Marrelli,Roberta Ruggiero et al.
Vincenzo Vertucci et al.
Zirconia and polyetheretherketone (PEEK) are two biomaterials widely investigated as substitute for metals in oral prosthetic rehabilitation. To achieve a proper biomechanical behavior, the prosthetic biomaterials must ensure a good resista...
Salt Restriction and Angiotensin-Converting Enzyme Inhibitor Improve the Responsiveness of the Small Artery in Salt-Sensitive Hypertension [0.03%]
限盐和血管紧张素转换酶抑制剂可改善盐敏感性高血压外周小动脉的反应性
Shi-Cheng Li,Tong-Meng Jiang,Jia-Hao Zhang et al.
Shi-Cheng Li et al.
For salt-sensitive hypertension (SSH), salt restriction and angiotensin-converting enzyme (ACE) inhibitors are essential treatments, but their effect on the function of resistance arteries is unclear. Here, we present an intravital study to...
Comparative-Effectiveness of Oral Beta-Lactams and Fluoroquinolones for Stepdown Therapy in Patients with Enterobacterales Bloodstream Infections: A Retrospective Cohort Study [0.03%]
口服β-内酰胺类与氟喹诺酮类药物治疗肠杆菌目血流感染序贯疗法的疗效比较：回顾性队列研究
Lauren Bjork,Teri Hopkins,Linda Yang et al.
Lauren Bjork et al.
Background: This study compares treatment failure for patients who received oral beta-lactams (BLs) and fluoroquinolones (FQs) for stepdown treatment of Enterobacterales bloodstream infections (BSIs). Methods: We conducted a single-center, ...
18β-glycyrrhetinic Acid Modulated Autophagy is Cytotoxic to Breast Cancer Cells [0.03%]
甘草酸通过调节自噬毒性杀死乳腺癌细胞
Yu-Chih Hsu,Wen-Che Hsieh,Shu-Hsin Chen et al.
Yu-Chih Hsu et al.
The development of endocrine therapy resistance in the luminal A subtype of breast cancer is related to the appearance of protective autophagy. The bioactive component from the root of licorice, 18β-glycyrrhetinic acid (18β-GA), has many ...
What is the optimal prolactin cutoff for predicting the presence of a pituitary adenoma in patients with polycystic ovary syndrome? [0.03%]
多囊卵巢综合征患者垂体腺瘤的最优泌乳素截断值是多少？
Sang Il Kim,Joo Hee Yoon,Dong Choon Park et al.
Sang Il Kim et al.
Objective: Hyperprolactinemia (HPRL) and polycystic ovary syndrome (PCOS) are common causes of infertility in women of reproductive age. A pituitary adenoma (PA) is the most common type of brain tumor that causes HPRL. In the neurosurgical ...