Molecular Autopsy in Asphyxia Deaths: Diagnostic Perspectives of miRNAs in the Evaluation of Hypoxia Response [0.03%]
分子自体解剖在窒息死亡中的诊断视角：miRNA在评估缺氧反应中的作用
Matteo Scopetti,Martina Padovano,Federico Manetti et al.
Matteo Scopetti et al.
The forensic investigation of asphyxia deaths still poses a challenge due to the need to demonstrate vital exposure to hypoxic insult according to high levels of evidence. The pulmonary effects of hypoxia are complex and the understanding o...
A Novel Lymphangiogenesis-Related Gene Signature can Predict Prognosis and Immunosuppressive Microenvironment in Patients with Clear Cell Renal Cell Carcinoma [0.03%]
一种新型的淋巴管生成相关基因特征可以预测透明细胞肾细胞癌患者的预后和免疫抑制微环境
Ke Chen,Mingchao Gao,Wen Dong et al.
Ke Chen et al.
Background: Lymphangiogenesis represents a key event in the progression and metastasis of patients with clear cell renal cell carcinoma (ccRCC). Nevertheless, the prognostic value of lymphangiogenesis-related genes (LRGs) in ccRCC patients ...
Recombinant Klotho attenuates IFNγ receptor signaling and SAMHD1 expression through blocking NF-κB translocation in glomerular mesangial cells [0.03%]
重组Klotho通过阻止NF-κB转位来抑制IFNγ受体信号传导和SAMHD1表达以减轻系膜细胞损伤
Kuen-Daw Tsai,Yi-Chao Lee,Bo-Yu Chen et al.
Kuen-Daw Tsai et al.
Interferon gamma (IFNγ) is a cytokine implicated in the pathogenesis of autoimmune diseases. SAM and HD domain-containing protein 1 (SAMHD1) is an IFNγ-inducible protein that modulates cellular dNTP levels. Mutations in the human SAMHD1 g...
Regulatory mechanisms and clinical applications of tumor-driven exosomal circRNAs in cancers [0.03%]
肿瘤来源的circRNA调控机制及临床应用研究进展
Xiangyu Meng,Dong Yang,Bao Zhang et al.
Xiangyu Meng et al.
Malignant tumors seriously affect people's survival and prognosis. Exosomes, as vesicle structures widely existing in human tissues and body fluids, are involved in cell-to-cell transmission. Tumor-derived exosomes were secreted from tumors...
Peripheral Parenteral Nutrition Solutions and Bed Bath Towels as Risk Factors for Nosocomial Peripheral Venous Catheter-related Bloodstream Infection by Bacillus cereus [0.03%]
外周肠外营养液和床上擦浴毛巾作为Bacillus cereus引起的医院相关外周静脉导管相关血流感染的风险因素
Chieko Hino,Masakazu Ozaki,Takashi Kitahara et al.
Chieko Hino et al.
In Japan, China, and Singapore, several studies have reported increased incidences of peripheral venous catheter-related bloodstream infection by Bacillus cereus during the summer. Therefore, we hypothesized that bed bathing with a B. cereu...
SIRT6 ameliorates LPS-induced apoptosis and tight junction injury in ARDS through the ERK1/2 pathway and autophagy [0.03%]
SIRT6通过ERK1/2通路和自噬改善LPS诱导的ARDS细胞凋亡和紧密连接损伤
Hanhan Liu,Sijiao Wang,Linjing Gong et al.
Hanhan Liu et al.
Sirtuin6 (SIRT6) has been demonstrated to be involved in a range of physiological processes and diseases, while its role in acute respiratory distress syndrome (ARDS) remains unclear. Therefore, this study focused on the role and underlying...
Transcriptomic Profiling of circRNAs in rat Hippocampus after Deep Hypothermic Circulatory Arrest [0.03%]
大动脉手术深低体温缺血再灌注损伤后海马环形RNA差异表达及功能预测分析
Tianlong Wang,Weidong Yan,Shengqiang Pei et al.
Tianlong Wang et al.
Neurologic abnormalities occurring after deep hypothermic circulatory arrest (DHCA) remain a significant concern. However, molecular mechanisms leading to DHCA-related cerebral injury are still ill-defined. Circular RNAs (circRNAs) are a cl...
Dental Caries, Dental Erosion and Periodontal Disease in Children with Inflammatory Bowel Disease [0.03%]
炎症性肠病儿童的龋齿、牙本质过敏和牙周病患病状况研究
Eda Haznedaroglu,Esra Polat
Eda Haznedaroglu
Background: There is reportedly a higher prevalence of dental caries and periodontal disease in adults with inflammatory bowel disease (IBD) than in healthy adults. Similar data for children are lacking in the literature. We aimed to evalua...
Sex-specific genetic variants associated with adult-onset inguinal hernia in a Taiwanese population [0.03%]
台湾成人腹股沟疝的性特异性遗传变异
Hsin-Chien Yen,I-Chieh Chen,Guan-Cheng Lin et al.
Hsin-Chien Yen et al.
Introduction: Inguinal hernia repair is one of the most common surgeries worldwide. However, there is limited information on its underlying genetic mechanism. Studies on the genetic factors related to inguinal hernia in Han Chinese are lack...
Farnesoid X receptor is inhibited after ileum transposition in diabetic rats: its hypoglycemic effect [0.03%]
糖尿病大鼠回肠移植后的法尼醇X受体抑制及其降糖作用
Weijie Chen,Shengnan Zhou,Jianchun Xiao et al.
Weijie Chen et al.
Background: Aim to investigate bile acid profile changes and the Farnesoid X receptor (FXR) status after ileotransposition (IT), and reveal its possible hypoglycemic mechanism. Methods: Twenty male diabetic rats were randomly assigned into ...