Real-World Safety of Anti-EGFR Antibodies: 20-Year Pharmacovigilance of Cetuximab and Panitumumab [0.03%]
抗EGFR抗体的现实世界安全性：西妥昔单抗和帕尼单抗20年的药物警戒监测
Liang-Yan Jin,Guo-Quan Chen,Jun Xie et al.
Liang-Yan Jin et al.
Background: Colorectal cancer remains a major contributor to global cancer-related mortality. Although EGFR-targeted monoclonal antibodies (cetuximab, panitumumab) have demonstrated efficacy in improving clinical outcomes, their associated ...
Deep Learning Based on Automated Breast Volume Scanner Images for the Diagnosis of Breast Lesions: A Multicenter Diagnostic Study [0.03%]
基于自动乳腺体积扫描图像的深度学习在乳腺病变诊断中的应用：多中心诊断研究
Hui Liu,Ying Zhang,Bin Tan et al.
Hui Liu et al.
Objectives: To develop a deep learning (DL) model for the automated detection and diagnosis of breast cancer utilizing automated breast volume scanner (ABVS) images, and to compare its diagnostic performance with that of radiologists in scr...
Circulating miRNAs are Down-regulated in Asthmatic Patients; Case-control Study [0.03%]
哮喘患者循环miRNA表达水平下调：一项病例对照研究
Christian A Trejo-Jasso,Héctor Isaac Rocha-González,Eduardo Montes-Martínez et al.
Christian A Trejo-Jasso et al.
Purpose: Microribonucleic acids (miRNAs) play an important role as non-invasive biomarkers and predictors of inflammatory disease activity. This study aimed to determine differences in expression profiles of miRNAs in patients with asthma c...
Exploring the relationship between exercise and diabetes risk in a prediabetes population [0.03%]
探索运动与糖尿病高危人群糖尿病风险的关系
Chih-Wei Chiang,Oswald Ndi Nfor,Wen-Yu Lu et al.
Chih-Wei Chiang et al.
The global incidence of prediabetes is on the rise, with an estimated 5 to 10% of individuals expected to transition to diabetes. We investigated factors associated with the progression of prediabetes to diabetes. Our primary data source wa...
Yun Hu,Juanjuan Li,Li Tian et al.
Yun Hu et al.
Sensorineural hearing loss (SNHL)'s incidence is on the rise, severely affecting the quality of life of patients and even causing psychological and mental damage. It also poses a heavy burden on the global healthcare system. The auditory pr...
CHAF1B: the hidden culprit behind sorafenib resistance in hepatocellular carcinoma [0.03%]
CHAF1B：肝细胞癌索拉非尼耐药的幕后黑手
Wenfeng Zhuo,Jiali Zhao,Zhouying Zheng et al.
Wenfeng Zhuo et al.
Introduction: Chromatin assembly factor 1B (CHAF1B), a pivotal regulator of chromatin assembly following DNA replication, has been implicated in oncogenic processes. However, its role in sorafenib resistance and potential anti-tumor mechani...
Association of Fine Particulate Matter (PM2.5) and Wet-Bulb Globe Temperature (WBGT) with Osteoporosis Incidence: A Nationwide Prospective Cohort Study [0.03%]
基于全国前瞻性队列的细颗粒物(PM2.5)和湿球黑球温度(WBGT)与骨质疏松症发病关联研究
En-Che Chang,Fu-Wen Liang,Jiun-Chi Huang et al.
En-Che Chang et al.
Background: Fine particulate matter (PM2.5) negatively impacts human health, contributing to cardiovascular, kidney, and lung diseases, as well as cancer. Emerging evidence suggests that PM2.5 exposure may also impair bone density, increasi...
Plasma Proteome Profiling Identifies Biomarkers and Potential Drug Targets for Non-Small Cell Lung Cancer [0.03%]
血浆蛋白质组分析鉴定非小细胞肺癌的生物标志物和潜在治疗靶点
Minghui Zhao,Xiaoke Di,Yucui Zhao
Minghui Zhao
Non-small cell lung cancer (NSCLC), as one of the most commonly diagnosed cancers globally, requires expedited identification of new drug targets. We conducted proteome-wide MR using genetic data for 4,853 plasma proteins. Summary-level dat...
Targeting LC3B/MCL-1 expression by Protodioscin induces autophagy and apoptosis in human glioblastoma cells in vitro and in vivo [0.03%]
原生卢丁通过靶向LC3B / MCL-1诱导胶质母细胞体外和体内自噬和凋亡
Ching-Ting Tai,Yi-Hsien Hsieh,Hsiang-Lin Lee et al.
Ching-Ting Tai et al.
Protodioscin (PD), a natural steroidal saponin extracted from Dioscorea and Tribulus terrestris, has been shown to exhibit anticancer, antimetastatic, and pro-autophagic and apoptotic activities in various malignant tumor cells. However, it...
Drug Interaction of Dasatinib with Thymoquinone: A Pharmacokinetic Study in Rats [0.03%]
达沙替尼与丹参酮 ⅡA 的药物相互作用：大鼠药代动力学研究
Ajaz Ahmad,Mohammad Raish,Khalid M Alkharfy et al.
Ajaz Ahmad et al.
Dasatinib (DAS), a multi-kinase inhibitor targeting Src and BCR-ABL families, is approved for Ph+ acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CML). Its metabolism by CYP3A4 and transported by efflux pump P-glycoprot...