Cardiomyopeptide-Regulated PPARγ Expression Plays a Critical Role in Maintaining Mitochondrial Integrity and Preventing Cardiac Ischemia/Reperfusion Injury [0.03%]
心肌肽调节的PPARγ表达在维持线粒体完整性及预防心脏缺血再灌注损伤中起关键作用
Zitong Guo,Geng Qian,Xietian Pan et al.
Zitong Guo et al.
Background: Myocardial injury is prone to occur during myocardial ischemia-reperfusion, which further causes adverse cardiac events. Cardiomyopeptide (CMP) has been found to protect the heart against ischemia-reperfusion injury. The present...
Exploiting Mitochondria by Triggering a Faulty Unfolded Protein Response Leads to Effective Cardioprotection [0.03%]
触发错误的未折叠蛋白反应利用线粒体有效保护心脏
Yang Shen,Xin Gao,Ying Xiang et al.
Yang Shen et al.
This study investigates the role of Fundc1 in cardiac protection under high-altitude hypoxic conditions and elucidates its underlying molecular mechanisms. Using cardiomyocyte-specific Fundc1 knockout (Fundc1CKO ) mice, we demonstrated that...
Identification of common diagnostic genes and molecular pathways in endometriosis and systemic lupus erythematosus by machine learning approach and in vitro experiment [0.03%]
基于机器学习方法和体外实验识别子宫内膜异位症和系统性红斑狼疮的共有诊断基因及分子通路
Pusheng Yang,Yiping Zhu,Yaxin Miao et al.
Pusheng Yang et al.
Growing research suggests that endometriosis and systemic lupus erythematosus (SLE) are both chronic inflammatory diseases and closely related, but no studies have explored their common molecular characteristics and underlying mechanisms. B...
Zuojin Pill enhances gastrointestinal motility by modulating the pacemaker potentials in interstitial cells of Cajal through multiple signaling pathways [0.03%]
佐金丸通过多条信号通路调控间质细胞慢波活动改善胃肠动力作用机制研究
Jueun Lee,Seok Jae Ko,Na Ri Choi et al.
Jueun Lee et al.
Zuojin Pill (ZJP) is a traditional herbal preparation used to treat various gastrointestinal (GI) disorders. The purpose of this study was to elucidate the underlying cellular and molecular mechanisms by evaluating the effects of ZJP on the...
Predisposing factors for poor outcomes after intense pulsed light treatment for dry eye disease: A retrospective case-control study [0.03%]
强脉冲光治疗干眼不良反应的危险因素分析：病例对照研究
Chia-Yi Lee,Shun-Fa Yang,Hung-Chi Chen et al.
Chia-Yi Lee et al.
Purpose: To evaluate the potential risk factors for poor dry eye disease (DED) outcomes after intense pulse light (IPL) treatment. Methods: A retrospective case-control study was conducted, and patients who received IPL were enrolled. A tot...
Arbutin overcomes tumor immune tolerance by inhibiting tumor programmed cell death-ligand 1 expression [0.03%]
阿布丁通过抑制肿瘤细胞程序性死亡配体-1的表达来克服肿瘤免疫耐受性
Ching-Han Liu,Jing-Ru Weng,Li-Hsien Wu et al.
Ching-Han Liu et al.
Arbutin, predominantly derived from the bearberry plant, exhibits promising immunomodulatory properties. Given its ability to influence the programmed cell death-ligand 1/ programmed cell death-1 (PD-L1/PD-1) pathway, it is emerging as a po...
Overexpression of Glycosyltransferase 8 Domain Containing 1 Promotes Gastric Cancer Proliferation and Inhibits Apoptosis via Mediating PTPN6/JAK2/STAT3 Signaling Axis [0.03%]
糖基转移酶8结构域含1过表达通过介导PTPN6/JAK2/STAT3信号轴促进胃癌增殖并抑制凋亡
Yingying Sun,Wuqian Zhang,Qunyou Cong et al.
Yingying Sun et al.
Background: The mechanisms of gastric cancer (GC) occurrence and development are still unclear. Although glycosyltransferase 8 domain containing 1 (GLT8D1) has been implicated in GC, its specific role and molecular mechanisms in GC progress...
Predicting cervical insufficiency in twin pregnancies using ultrasound cervical measurements and elastography [0.03%]
产前超声测量及弹性成像预测双胎妊娠宫颈功能不全
Yi Huang,Qi Li,Weishe Zhang et al.
Yi Huang et al.
Background: To evaluate the predictive effect of transvaginal ultrasound measurement of cervical length and cervical elasticity examination on cervical insufficiency in twin pregnancies. Methods: Data from twin pregnant women in our hospita...
Co-inhibition of PGF and VEGFA enhances the effectiveness of immunotherapy in bladder cancer [0.03%]
PGF和VEGFA共抑制可增强免疫疗法在膀胱癌中的疗效
Xianzhi Yang,Haoxiang Zheng,Jianxu Huang et al.
Xianzhi Yang et al.
Background: Anti-angiogenic inhibitors and immune checkpoint blockade combination therapy offers a novel approach to circumvent the challenges associated with limited responsiveness to checkpoint inhibitors in bladder cancer. However, the e...
Research Progress on the Application of CGM in Patients with Diabetes and Hemodialysis [0.03%]
糖尿病合并血液透析患者持续葡萄糖监测(CGM)应用研究进展
Ping Huang,Jing He,Liansheng Ren et al.
Ping Huang et al.
Diabetes mellitus is the main cause of end-stage renal disease (ESKD), and most patients need hemodialysis (HD) treatment after they progress to uremia. Patients with diabetes and HD have obvious blood glucose fluctuation, hyperglycemia and...