Receptor-Interacting Protein Kinase 3-Mediated Modulation of Endothelial Cell Necroptosis and Mitochondrial Dysfunction through AMPK/Drp1 Signaling Pathway: Insights into the Pathophysiological Mechanisms of Lipopolysaccharide-Induced Acute Lung Injury [0.03%]
受体相互作用蛋白激酶3介导的AMPK/Drp1信号通路调控内皮细胞坏死性凋亡和线粒体功能障碍：脂多糖诱导急性肺损伤病理生理机制研究新进展
Zhaoning Zhao,Pingjun Zhu,Yue Lou et al.
Zhaoning Zhao et al.
Receptor-interacting protein 3 (Ripk3) plays a crucial part in acute lung injury (ALI) by regulating inflammation-induced endothelial damage in the lung tissue. The precise mechanisms through which Ripk3 contributes to the endothelial injur...
Chen Chang,Wan-Zhong Huang,Ru-Ping Cai et al.
Chen Chang et al.
Coronary microembolization (CME) is defined as atherosclerotic plaque erosion, spontaneous rupture, or rupture of the plaque while undergoing interventional therapy resulting in the formation of tiny emboli that obstruct the coronary microc...
Liver B Cells Promotes MASLD Progression via the Apelin/APLNR System [0.03%]
肝B细胞通过Apelin/APLNR系统促进MASLD进展
Su Jiang,Jiaxue Lu,Nan Li et al.
Su Jiang et al.
Aims: Investigate the role of the apelin/APLNR axis in metabolic dysfunction-associated steatotic liver disease (MASLD), focusing on the progression from metabolic dysfunction-associated simple steatotic liver (MASS) to metabolic dysfunctio...
Silencing PCCA Suppresses CRC Growth and Spread by Modulating EMT and M1 Macrophage Polarization [0.03%]
沉默PCCA通过调节上皮间质转化和M1巨噬细胞极化来抑制结直肠癌的生长和转移
Chuyi Zhang,Zhinan Zheng,Huaiming Wang et al.
Chuyi Zhang et al.
Background: The progression and metastasis of colorectal cancer (CRC) remain major clinical challenges due to a lack of effective therapeutic targets. Our preliminary study identified the upregulation of the propionyl-CoA carboxylase alpha ...
Analysis of User-Generated Posts on Social Media of Adjuvant Analgesics: A Machine Learning Study [0.03%]
一种机器学习研究：辅助止痛药社交媒体用户生成内容的分析
Federico Carabot,Carolina Donat-Vargas,Francisco J Lara-Abelenda et al.
Federico Carabot et al.
Background: Antiepileptics and antidepressants are frequently prescribed for chronic pain, but their efficacy and potential adverse effects raise concerns, including dependency issues. Increased prescriptions, sometimes fraudulent, prompted...
Cadherin 23 is a prognostic marker of pancreatic cancer and promotes cell viability in floating culture conditions [0.03%]
cadherin 23是胰腺癌的预后标志物并在悬浮培养条件下促进细胞存活
Chaohui Zhen,Peiwei Sun,Rui Liang et al.
Chaohui Zhen et al.
Purpose: Pancreatic cancer has the worst prognosis of all common cancers worldwide. Cadherin plays important roles in cancer cell invasion and metastasis. This study investigated the role and mechanism of Cadherin 23 (CDH23) action in the v...
Identification of JNK-JUN-NCOA axis as a therapeutic target for macrophage ferroptosis in chronic apical periodontitis [0.03%]
鉴定JNK-JUN-NCOA轴为慢性尖周炎巨噬细胞铁死亡治疗靶点
Yuting Wang,Wenlan Li,Wenli Mu et al.
Yuting Wang et al.
Objectives: This study aimed to investigate the involvement of macrophage ferroptosis in chronic apical periodontitis (CAP) and determine if blocking JNK/JUN/NCOA4 axis could alleviate CAP by regulating macrophage ferroptosis. Materials and...
Therapeutic potential of Astragalus-based Eefooton in patients with chronic kidney disease: from clinical to bench study [0.03%]
黄芪类复方在慢性肾脏病患者中的治疗潜力：从临床到基础研究
Kuo-Cheng Lu,Ko-Lin Kuo,San-Chiang Wu et al.
Kuo-Cheng Lu et al.
Objective: Chronic kidney disease (CKD) is a global health concern, and recent clinical evidence suggests the potential of traditional Chinese medicine (TCM) to slow CKD progression. This offers alternative strategies for CKD patients, miti...
Identification and validation of Novel Estrogen Biosynthesis Biomarkers in Sinonasal Inverted Papilloma [0.03%]
鼻腔 inverted papilloma雌激素生物合成新标志物的鉴定和验证
Yi-Fang Yang,Sung-Huan Yu,Jia-Bin Liao et al.
Yi-Fang Yang et al.
Background: Sinonasal inverted papilloma (SNIP) is characterized by a high recurrence rate and potential for malignant transformation. Although metabolic reprogramming plays a role in benign neoplasms, the specific metabolic pathways and bi...
Ginsenosides, salidroside, and syringin complex exhibits anti-fatigue in exhaustive exercise rats [0.03%]
三七总皂苷与红景天苷和白桦脂醇葡萄糖苷复方对力竭运动大鼠抗疲劳作用研究
Yung-Chun Wu,Yu Zhi Lian,Hongwei Zhao et al.
Yung-Chun Wu et al.
Excessive exercise can lead to fatigue, consequently affect exercise performance, and further have an adverse impact to human health. The synergistic effects of ginsenosides, salidroside, and syringin on improving exercise performance remai...