Taming Pancreatic Cancer: Ardisia virens Kurz-Derived 4-Hydroxy-2-Methoxy-6-Tridecylphenyl Acetate as a Potent Tubulin Polymerization Inhibitor for Targeted Pancreatic Ductal Adenocarcinoma Therapy [0.03%]
利用kurz拟万寿菊素抑制微管聚合治疗胰腺导管腺癌
Chia-Hung Yen,Chien-Ju Lin,Peng-Yu Chen et al.
Chia-Hung Yen et al.
Pancreatic ductal adenocarcinoma (PDAC) is a major global health challenge owing to late diagnosis and inherently metastatic nature. Although surgical intervention offers a potential remedy, only few patients are eligible, and drug resistan...
Protective effects of MET channels on aminoglycosides- and cisplatin-induced ototoxicity [0.03%]
MET通道对氨基糖苷类和顺铂耳毒性的保护作用
Lile Ouyang,Lu Ma,Yong Feng
Lile Ouyang
Aminoglycosides and cisplatin drugs are extensively utilized for their high efficacy in treating various conditions in the clinic, however, their ototoxic side effects warrant significant attention. These drugs could penetrate the inner ear...
Trends in Blood Pressure Control in US Adult CKD Patients from 1999 to 2018 [0.03%]
美国成人CKD患者血压控制趋势（1999-2018）
Anbang Sun,Lin Zhu,Yanmin Xia et al.
Anbang Sun et al.
Background: Blood pressure (BP) control can slow down the progression of chronic kidney disease (CKD) and protect against cardiovascular diseases, significantly improving patient survival. Herein, we analyzed the changes in BP control in ad...
The relationship between long noncoding RNA H19 genotypes and the clinical features of diabetic retinopathy [0.03%]
lncRNA H19基因多态性与糖尿病视网膜病变临床特征的关系研究
Michael Chia-Yen Chou,Hsiang-Wen Chien,Chia-Yi Lee et al.
Michael Chia-Yen Chou et al.
Diabetic retinopathy (DR) is a microvascular complication of diabetes characterized by an inflammatory response. The H19 gene plays a role in regulating inflammation and is associated with chronic systemic inflammation. This study aims to i...
Olfactory and Gustatory Disturbances as Early Indicators of Lung Cancer in Patients with Sleep Disorders: A Retrospective Cohort Study from the TriNetX US Collaborative Networks [0.03%]
睡眠障碍患者的嗅觉和味觉紊乱作为肺癌早期指标的回顾性队列研究：来自TriNetX美国协作网络的数据
Ru-Yin Tsai,Chi-Chung Ho,Jhen-You Hu et al.
Ru-Yin Tsai et al.
Background: Olfactory and gustatory disturbances are commonly overlooked symptoms but may be linked to various health conditions, including cancer. Emerging evidence suggests that these sensory impairments could be early indicators of lung ...
Evaluation of bone-protecting effects of palm carotene mixture in two- and three-dimensional osteoblast/osteoclast co-culture systems [0.03%]
评价红棕榈色素混合物对骨保护作用的体外实验研究
Michelle Min-Fang Yee,Kok-Yong Chin,Soelaiman Ima-Nirwana et al.
Michelle Min-Fang Yee et al.
Background: Carotene exists naturally in a complex mixture consisting of alpha (α), beta (β), and gamma (γ)-isoforms. Previous studies investigated the effects of individual carotene isomers on bone rather than their actions in a mixture...
Glycosphingolipids-Dependent Phospholipid Metabolism Enhances Cancer Initiation and Progression through SMPD1/GLTP/B3GALT4/ST8SIA6 Signaling Axis: A Novel Therapeutic Target [0.03%]
糖脂依赖性磷脂代谢通过SMPD1/GLTP/B3GALT4/ST8SIA6信号轴增强癌症的发生和发展：一种新型治疗靶点
Liangpan Shi,Nanqi Mao,Zhihua Zheng et al.
Liangpan Shi et al.
Colorectal cancer (CRC) is a prevalent malignancy with high morbidity and mortality rates globally. Advances in single-cell sequencing technology have enabled comprehensive analyses of tumor cells at single-cell resolution, providing valuab...
Spinal Metastasis Pain Surveillance: A Comprehensive Imaging-Based Tool Design for Evaluating Metastatic Burden and Guiding Therapeutic Strategies [0.03%]
基于影像的脊柱转移疼痛监测工具的设计：评估转移负担和指导治疗策略
Shuxin Kong,Aishi Deng,Zeyin Guo et al.
Shuxin Kong et al.
Background: The current research aims to elucidate the interplay between the anatomical distribution of spinal metastases, MRI features, and the intensity of bone pain in patients with breast cancer. Methods: A retrospective analysis was us...
Elevated Serum TSH Levels and TPOAb Positivity in Early Pregnancy are Associated with Increased Risk of Hypertensive Disorders of Pregnancy: A Prospective Cohort Study [0.03%]
妊娠早期血清TSH水平升高和TPOAb阳性与妊娠期高血压疾病的发病风险增加相关：一项前瞻性队列研究
Minhui Hu,Shen Gao,Kaikun Huang et al.
Minhui Hu et al.
Background: The relationship between maternal thyroid-stimulating hormone (TSH), free thyroxine (FT4) and thyroid peroxidase antibody (TPOAb) status and hypertensive disorders of pregnancy (HDP) remains uncertain. Methods: This was a prospe...
A novel nomogram on predicting extrahepatic metastasis in colorectal cancer with liver metastasis for selective application of 18F-FDG PET/CT [0.03%]
一项预测结直肠癌肝转移患者发生远处转移的列线图用于选择性应用18F-FDG PET/CT检查
Rongtao Zhu,Yipu Zhao,Jie Zhao et al.
Rongtao Zhu et al.
Background: A more accurate assessment of extrahepatic metastases (EHMs) with colorectal cancer liver metastases (CRLMs) improve patient prognosis without unnecessary surgery and economic burden. At present, PET-CT can only be used as a sec...