S1R mediates NRF2 dependent ferroptosis of renal tubular epithelial cells to promote renal fibrosis in diabetic nephropathy [0.03%]
S1R介导肾小管上皮细胞的NRF2依赖性铁死亡以促进糖尿病肾病的肾纤维化
Cheng Yuan,Fengpei Chang,Qiuyuan Zhou et al.
Cheng Yuan et al.
Rationale: Tubulointerstitial fibrosis is a key pathological aspect of diabetic nephropathy (DN) linked to reduced kidney function. Recent research has identified varied functions of the sigma-1 receptor (S1R) in the pathological fibrosis p...
Xing Du,Zhongyao Chen,Wei Shui
Xing Du
Clusterin (CLU) is a glycoprotein that exists in various forms in cells, including nuclear, cytoplasmic, and secreted types. The relative molecular weight of CLU varies significantly due to differences in glycosylation and cleavage. Althoug...
Effects of 100 IU versus 150 IU hCG supplementation on oocyte and embryo quality in patients aged ≥ 35 years: a propensity score-matched analysis [0.03%]
对于≥35岁的患者，100国际单位与150国际单位hCG补充对卵母细胞和胚胎质量的影响：倾向评分匹配分析
Nguyen Thi Lien Huong,Tran Thu Thuy,Phi Thi Tu Anh et al.
Nguyen Thi Lien Huong et al.
Background: The optimal dose of human chorionic gonadotropin (hCG) supplementation during controlled ovarian stimulation (COS) remains controversial, particularly in women of advanced reproductive age. Objective: To compare the efficacy and...
Predictivity of Hepatic Steatosis Index for Gestational Hypertension and Preeclampsia: a Prospective Cohort Study [0.03%]
肝脂肪变性指数对妊娠期高血压和子痫前期的预测价值：一项前瞻性队列研究
Lin Zhang,Shen Gao,Yingyi Luan et al.
Lin Zhang et al.
Context: Previous studies have reported that pregnant women with non-alcoholic fatty liver disease (NAFLD) face an increased risk of gestational hypertension (GH) and preeclampsia (PE). However, no study has assessed the relationship betwee...
Extracts of Portulaca oleracea and Patrinia scabiosaefolia relieve ultraviolet B-induced skin injury in solar dermatitis mice via inhibiting IL-17/CCL2 pathway and oxidative stress [0.03%]
马齿苋和刺柏提取物通过抑制IL-17/CCL2通路及氧化应激缓解光皮肤病小鼠的紫外线诱导的皮肤损伤
Bowei Li,Jingyuan Yang,Zhixing Wang et al.
Bowei Li et al.
Introduction: Solar dermatitis, a condition triggered by excessive exposure to ultraviolet B (UVB) radiation, results in inflammatory skin damage marked by erythema, edema, and epidermal injury. Portulaca oleracea (PO) and Patrinia scabiosa...
Kidney Injury under Diminished Pulsatile Flow Induced by V-A ECMO in Sheep [0.03%]
羊V-A体外膜肺氧合诱导的脉动血流降低所致的肾损伤研究
Weidong Yan,Tianlong Wang,Jiachen Qi et al.
Weidong Yan et al.
Extracorporeal membrane oxygenation (ECMO) is commonly used for critically ill patients and associated with high rates of kidney injury and mortality. This study aimed to assess the impact of diminished pulsatile flow induced by veno-arteri...
The Role of HK2 in Tumorigenesis and Development: Potential for Targeted Therapy with Natural Products [0.03%]
HK2在肿瘤发生与发展中的作用：天然产物针对性治疗的可能性
Keren He,Fangfang Tao,Yangyuxiao Lu et al.
Keren He et al.
Hexokinase 2 (HK2) is widely distributed in various tissues, particularly showing significantly elevated expression levels in tumor tissues. As the initial rate-limiting enzyme in the glycolysis process, HK2 is believed to directly particip...
LRP5 enhances glioma cell proliferation by modulating the MAPK/p53/cdc2 pathway [0.03%]
LRP5通过调节MAPK / p53 / cdc2通路促进胶质瘤细胞增殖
Ying-Yi Feng,Xin Jin,Min-Xuan Pan et al.
Ying-Yi Feng et al.
Background: Glioma is a malignant neoplasm with generally poor prognosis and the treatment options and effective drugs are very limited. LRP5, a member of the low-density lipoprotein receptor (LDLR) gene family, has been reported to regulat...
Intramuscular Injection of rAAV2-retro for Low Motor Neuron Transduction: Evaluating Five Promoters [0.03%]
用于低运动神经元转导的rAAV2-retro肌肉注射：评估五个启动子
Xueqi Gong,Haitong Gao,Wenyuan Wang et al.
Xueqi Gong et al.
Recombinant adeno-associated viral vectors (rAAVs) can effectively deliver transgene to the nervous system. The selection of AAV serotype and promoter significantly influences the dynamics of the transgene expression, including its strength...
Long sleep duration and good sleep quality reduced incident peptic ulcer disease in a large Taiwanese population follow-up study [0.03%]
长时间睡眠和良好的睡眠质量可以降低台湾地区人群患消化性溃疡的发病率
Yi-Hsiang Huang,Hsin-Yi Huang,Jia-In Lee et al.
Yi-Hsiang Huang et al.
Poor sleep has been associated with diseases including cardiovascular, obesity and mental disorders. However, there is limited information on the correlation between sleep duration and quality with peptic ulcer disease (PUD). This study aim...