Novel Insights into PGM2L1 as a Prognostic Biomarker in Cholangiocarcinoma: Implications for Metabolic Reprogramming and Tumor Microenvironment Modulation [0.03%]
PGM2L1作为胆管癌预后生物标志物的新见解：对代谢重编程和肿瘤微环境调节的影响
Guo-Wei Wu,Yi-Hsien Hsieh,Yi-Chung Chien et al.
Guo-Wei Wu et al.
Cholangiocarcinoma (CCA) is a highly lethal malignancy and the most common adenocarcinoma of the hepatobiliary system. PGM2L1 belongs to the α-D-phosphohexomutase superfamily and functions as a glucose 1,6-bisphosphate (G16BP) synthase. Th...
Downregulation of lncRNA MNX1-AS1 promotes the ferroptosis and apoptosis of non-small cell lung cancer [0.03%]
lncRNA MNX1-AS1低表达促进非小细胞肺癌的铁死亡和凋亡
Xinming Chi,Lingya Feng,Longzhu Wang et al.
Xinming Chi et al.
Non-small cell lung cancer (NSCLC), the main histological type of lung cancer, poses a serious threat to human health. Increasing evidence has shown that long non-coding RNA (lncRNA) MNX1-AS1 is involved in the development and progression o...
CD36 knockdown attenuates pressure overload-induced cardiac injury by preventing lipotoxicity and improving myocardial energy metabolism [0.03%]
CD36基因敲除通过防止脂毒作用和改善心肌能量代谢减轻压力超负荷引起的心脏损伤
Jing Geng,Xiaoliang Zhang,Ying Wang et al.
Jing Geng et al.
Introduction: The heart predominantly derives its energy from fatty acid (FA) oxidation. However, the uncoupling of lipid uptake and FA oxidation can result in abnormal cardiac lipid accumulation and lipotoxicity, particularly in the contex...
Ceramide Complex Ameliorates Metabolically Driven Neutrophil Senescence by Regulating Apoptosis via the cGAS-STING Pathway [0.03%]
神经酰胺复合物通过调节cGAS-STING通路的凋亡来改善代谢驱动的中性粒细胞衰老
Xi Gao,Cheng Lu,Kaixuan Wang et al.
Xi Gao et al.
Background: Population aging is increasingly recognized as a major global challenge. Researchers have identified a correlation between aging and immunosenescence, leading to dysfunction of the immune system. As a crucial component of the in...
Aberrant DNA Methylation in Esophageal Squamous Cell Carcinoma and its Clinical Implications in Systemic Chemotherapy [0.03%]
食管鳞状细胞癌的异常DNA甲基化及其在全身化疗中的临床意义
Zhao Li,Xi Chen,Yongkang Li et al.
Zhao Li et al.
Esophageal cancer is a significant global health concern, with esophageal squamous cell carcinoma being the predominant subtype in high-incidence regions like China. Despite advances in multidisciplinary treatments, the prognosis for ESCC r...
Accuracy of Sonographic Renal Pelvic Diameter in Assessment of Renal Function among Patients with Ureteropelvic Junction Obstruction using Scintigraphy as a Gold Standard [0.03%]
超声测量肾盂直径在输尿管肾盂连接部梗阻患者中评估肾功能的准确性研究采用放射性核素扫描作为金标准
Mahasin G Hassan,Tasneem S A Elmahdi,Moudi Alotaibi et al.
Mahasin G Hassan et al.
Objectives: The study aimed to assess the diagnostic accuracy of sonographic renal pelvic diameter (RPD) in pediatric patients with ureteropelvic junction obstruction (UPJO) and its potential as a solo diagnostic tool. The study also looked...
Metabolic dysfunction-associated fatty liver disease as a mediator of urolithiasis risk: evidence from cross-sectional and genetic studies [0.03%]
代谢功能障碍相关性脂肪肝作为尿石症风险的中介因素：横断面和遗传学研究的证据
Lin-Tao Miao,Wen-Jie Wang,Jin-Zhou Xu et al.
Lin-Tao Miao et al.
Introduction: The rising prevalence of urolithiasis and metabolic dysfunction-associated fatty liver disease (MAFLD) has become a significant concern within urology and hepatology, respectively. Emerging studies reveal a compelling associat...
Understanding Genetic Screening: Harnessing Health Information to Prevent Disease Risks [0.03%]
理解基因筛查：利用健康信息预防疾病风险
Chung-Lin Lee,Chih-Kuang Chuang,Huei-Ching Chiu et al.
Chung-Lin Lee et al.
Genetic screening analyzes an individual's genetic information to assess disease risk and provide personalized health recommendations. This article introduces the public to genetic screening, explaining its definition, principles, history, ...
Exploring the Potential of Moringa oleifera in Managing Bone Loss: Insights from Preclinical Studies [0.03%]
探討辣木（Moringa oleifera）在管理骨質流失中的潛力：前期研究的啟示
Haryati Ahmad Hairi,Rusdiah Ruzanna Jusoh,Muhammad Zulfiqah Sadikan et al.
Haryati Ahmad Hairi et al.
Moringa oleifera (MO) is renowned for its remarkable medicinal uses, supported by claims across various cultures and growing scientific evidence. Preclinical experimental evidence indicated that MO may effectively reduce bone loss and promo...
NCAPH Promotes the Proliferation of Prostate Cancer Cells Via Modulating the E2F1 Mediated PI3K/AKT/mTOR Axis [0.03%]
NCAPH通过调节E2F1介导的PI3K / AKT / mTOR通路促进前列腺癌细胞的增殖
Qing Shi,Jinpeng Ma,Xiang Pan et al.
Qing Shi et al.
Prostate cancer (PCa) remains a major challenge in oncology, driving the need for continuous exploration and development of innovative treatment strategies. NCAPH plays a critical role in tumorigenesis and progression across multiple cancer...