Escin Rescues Blood-brain Barrier and Inhibits NLRP3 Inflammasome-mediated Pyroptosis in Rats with Superior Sagital Sinus Thrombosis [0.03%]
马钱子素能挽救血脑屏障并抑制大鼠上矢状窦血栓形成的NLRP3炎性小体介导的焦亡
Min Li,Xinjian Liu,Xinyu Zhou et al.
Min Li et al.
Objective: The purpose of this study is to investigate the therapeutic value of escin and its potential mechanisms in rats with superior sagittal sinus thrombosis (SSST). Methods: The motor function of rats was assessed using the open field...
Inhibition of autophagy promotes ultrasound‑targeted microbubble destruction-induced apoptosis of pancreatic cancer cells [0.03%]
自噬抑制促进超声靶向微泡破坏诱导的胰腺癌细胞凋亡
Nan Chen,Xiaoyu Zhang,Ping Yang et al.
Nan Chen et al.
In therapeutic studies of pancreatic cancer, ultrasound-targeted microbubble destruction (UTMD) has shown potential in promoting apoptosis as a safe and non-invasive adjuvant therapy. Autophagy, a regulatory mechanism for cellular stress re...
Interleukin 26 attenuates osteoblast differentiation in osteoarthritis patients by activating COX2 and NF-κB pathways [0.03%]
白细胞介素26通过激活COX2和NF-κB通路减弱骨关节炎患者的成骨细胞分化
Yi-Hsuan Lin,Yi-Hsun Wang,Yi-Jen Peng et al.
Yi-Hsuan Lin et al.
Aims: Osteoarthritis (OA) represents the prevailing form of degenerative joint pathology. Recent investigations have revealed a heightened expression of interleukin 26 (IL-26) in various inflammatory arthritic conditions, including OA. Howe...
Impact of Chronic Kidney Disease on Aortic Dissection in Patients with Polycystic Kidney Disease: A Fifteen-year Nationwide Population-based Cohort Study in Taiwan [0.03%]
多囊肾病患者慢性肾脏疾病对主动脉夹层的影响：台湾十五年全国人口基础队列研究
Chia-Ning Fan,Chi-Hsiang Chung,Wu-Chien Chien et al.
Chia-Ning Fan et al.
Background: Aortic dissection is a life-threatening condition associated with polycystic kidney disease (PKD). Additionally, PKD often progresses to chronic kidney disease (CKD), a known risk factor for cardiovascular disease. However, the ...
Exploring the Shared Diagnostic Genes in IBD and Psoriasis through Bioinformatics and Experimental Assays [0.03%]
通过生物信息学和实验测定探索IBD和银屑病的共有诊断基因
Lichun Han,Guangfu Lin,Xiaodan Lv et al.
Lichun Han et al.
Background: Inflammatory bowel disease (IBD) is a persistent, non-specific inflammation affecting the intestines. Psoriasis is a long-lasting inflammatory disorder of the skin. There is a comorbidity correlation between IBD and psoriasis, b...
Knowledge Landscape and Hotspots of Research in Transthyretin Amyloid Cardiomyopathy: A Bibliometric Analysis [0.03%]
转甲状腺素蛋白心脏淀粉样变性研究的知识景观和热点： bibliometic分析
Yanzhi Liu,Xinqing Li,Anran Xin et al.
Yanzhi Liu et al.
Background: Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive and frequently underdiagnosed cause of heart failure characterized by the pathological deposition of misfolded transthyretin (TTR) proteins in the cardiac tissue, l...
Association between Triglyceride-Glucose Index and Prognosis in Critically Ill Patients with Acute Coronary Syndrome: Evidence from the MIMIC Database [0.03%]
甘油三酯-葡萄糖指数与急性冠脉综合征重症患者预后的相关性研究：来自MIMIC数据库的证据
Manqing Chen,Yuhui Yang,Weiwei Hu et al.
Manqing Chen et al.
Background: This study aimed to investigate the association between triglyceride-glucose (TyG) index and prognosis in critically ill patients with acute coronary syndrome (ACS), exploring potential heterogeneity of the association among pat...
Observational Study
International journal of medical sciences. 2025 Feb 26;22(7):1528-1541. DOI:10.7150/ijms.107976 2025
Dextrose Prolotherapy's Impact on the Urinary Microbiome in Interstitial Cystitis/Bladder Pain Syndrome [0.03%]
葡萄糖促质治疗对间质性膀胱炎/膀胱疼痛综合症尿液微生物群的影响
Liang-Kun Chen,Shu-Jen Chang,Chin-Li Chen et al.
Liang-Kun Chen et al.
Background: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating chronic condition affecting millions globally. Dextrose prolotherapy, a minimally invasive and safe treatment, has emerged as a potential way to promote tiss...
Circular RNA in Pancreatic Cancer: Biogenesis, Mechanism, Function and Clinical Application [0.03%]
胰腺癌中的环状RNA：生物合成、机制、功能及临床应用
Hang Chen,Xianxing Wang,Shan Liu et al.
Hang Chen et al.
Circular RNAs (circRNAs) are a class of novel RNA molecules featured by single-strand covalently closed circular structure, which not only are extensively found in eukaryotes and are highly conserved, but also conduct paramount roles in the...
SIRT6 mitigates doxorubicin-induced cardiomyopathy via amelioration of mitochondrial dysfunction: A mechanistic study implicating the activation of the Nrf-2/FUNDC1 signaling axis [0.03%]
SIRT6通过改善线粒体功能障碍来减轻多柔比星引起的心肌病：一种涉及激活Nrf-2/FUNDC1信号轴的机制研究
Qi Wang,Hongshuo Shi,Haowen Zhuang et al.
Qi Wang et al.
Doxorubicin-induced myocardial injury, characterized by myocardial hypertrophy and heart failure (HF), represents a primary contributor to end-stage cardiovascular mortality associated with anthracycline drugs. Prior research has elucidated...