RNA-binding proteins as a molecular link between COPD and pulmonary hypertension [0.03%]
作为COPD和肺动脉高压分子联系的RNA结合蛋白
Yi Liu,Ran Wang,Tao Jiang
Yi Liu
Pulmonary hypertension (PH) is a vascular disease characterized by remodeling of the pulmonary arteries and right heart failure. Chronic obstructive pulmonary disease (COPD) patients often have PH, which can worsen symptoms and raise morbid...
In Silico Identification of ANKRD22 as a Theragnostic Target for Pancreatic Cancer and Fostamatinib's Therapeutic Potential [0.03%]
ANKRD22的胰腺癌治疗诊断标志物潜力及福斯馬替尼的治療潛力之計算篩選研究
Huong Thi Luu Kim Huynh,Hendrick Gao-Min Lim,Yuan-Chii Gladys Lee et al.
Huong Thi Luu Kim Huynh et al.
Pancreatic cancer (PC) is one of the most tremendously malignant cancers with a poor prognosis, especially when it advances to metastasis. Besides, PC patients have encountered resistance to recent therapeutic approaches. In recent work, we...
FBXW2 inhibits the progression of gastric cancer via promoting β-catenin ubiquitylation [0.03%]
FBXW2通过促进β-连环蛋白泛素化抑制胃癌进展
Yanshen Kuang,Mu Ke,Weizheng Liu et al.
Yanshen Kuang et al.
Background: F-box and WD-repeat-containing protein 2 (FBXW2), an E3 ubiquitin ligase, may play a crucial role in tumorigenesis. However, its function in gastric cancer remains unknown. Methods: The expression levels of FBXW2 and β-catenin ...
Association of nutrient intake and dietary patterns with serum folate and anemia-related biomarkers in Taiwanese pregnant women with pre-pregnancy overweightness or obesity [0.03%]
孕前超重或肥胖的台湾孕妇膳食营养素摄入和饮食模式与血清叶酸及贫血相关生物标志物的关联分析
Nhi Thi Hong Nguyen,Chyi-Huey Bai,Jung-Su Chang et al.
Nhi Thi Hong Nguyen et al.
Pre-pregnancy overweightness or obesity affects nutritional status and micronutrient imbalance such as folate and iron during pregnancy. We studied the relationships between micronutrient intake and dietary patterns with serum folate and ir...
Non-epithelial Circulating Tumor Cells Enhance Disease Progression in High-risk Prostate Cancer through EMT and COL1A1 Expression [0.03%]
高危前列腺癌中通过上皮间充质转化和COL1A1表达促进疾病进展的非上皮循环肿瘤细胞
Yiyuan Li,Ruji Wu,Hua Wang et al.
Yiyuan Li et al.
Introduction: Circulating tumor cells (CTCs) are important prognostic indicators for malignancies. However, a reliable positive/negative cutoff value of non-epithelial (NE+: hybrid and mesenchymal) CTCs phenotype in prostate cancer (PCa) pa...
Association of lung immune prognostic index with overall survival in pancreatic ductal adenocarcinoma patients treated using chemotherapy [0.03%]
肺免疫预后指数与接受化疗的胰腺导管腺癌患者的总生存期的关系
Nan Zhang,Guochao Deng,Ru Jia et al.
Nan Zhang et al.
Background: The lung immune prognostic index (LIPI) has attracted considerable interest for its prognostic value in several malignancies. However, its prognostic value in pancreatic ductal adenocarcinoma (PDAC) has not yet been clarified. O...
Data Mining of the FDA Adverse Event Reporting System and Animal Experiments for Assessment of Rhabdomyolysis Risk Associated with Lipid-lowering Drugs [0.03%]
数据挖掘美国食品药品监督管理局不良事件报告系统和动物实验评估调脂药横纹肌溶解风险
Shinji Kobuchi,Daisuke Sugiyama,Anna Iima et al.
Shinji Kobuchi et al.
Despite extensive research on pharmacokinetic interactions between hydroxymethylglutaryl-CoA reductase inhibitors (statins) and fibrates, the underlying pharmacodynamic mechanisms contributing to the increased risk of rhabdomyolysis remain ...
Large-scale genomic-wide CRISPR screening revealed PRC1 as a tumor essential candidate in clear cell renal cell carcinoma [0.03%]
大规模基因组CRISPR筛查揭示了PRC1在透明细胞肾细胞癌中作为肿瘤必需基因的可能性
Baochao Li,Yongsheng Pan,Jiajin Wu et al.
Baochao Li et al.
Background: Clear cell renal cell carcinoma (ccRCC) is a prevalent and aggressive subtype of kidney cancer, often associated with metastasis and recurrence. Identifying key genes involved in ccRCC progression is critical for improving treat...
Quantification of Fascin-1-Positive Extracellular Vesicles by Nanoflow Cytometry for Early Detection of Hepatocellular Carcinoma in Liquid Biopsy [0.03%]
纳米流式细胞术定量检测Fascin-1阳性胞外囊泡以实现液体活检早期发现肝细胞性肝癌
Bodeng Wu,Zhenxun Wang,Guanbo Wang et al.
Bodeng Wu et al.
Background: Hepatocellular carcinoma (HCC) lacks effective early diagnostic biomarkers. Identifying extracellular vesicles (EVs)-associated biomarkers for early HCC detection in HCC progression is precise and critical. Methods: Databases, t...
Metabolic syndrome is associated with gastroesophageal reflux disease in a large Taiwanese population study [0.03%]
代谢综合症与胃食管反流病的关系在一项大型台湾人口研究中得到验证
Wen-Hung Hsu,Jiun-Hung Geng,Pei-Yu Wu et al.
Wen-Hung Hsu et al.
Gastroesophageal reflux disease (GERD) and metabolic syndrome (MetS) have emerged as prominent health issues in past decades. This study aimed to evaluate whether the presence of MetS and its constituent factors was associated with a higher...