Integrating Single-Cell and Bulk RNA Sequencing Data to Explore Sphingolipid Metabolism Molecular Signatures in Ovarian Cancer Prognosis: an Original Study [0.03%]
结合单细胞和批量RNA测序数据探索卵巢癌预后的鞘脂代谢分子标志物：一项原创性研究
Xu Huang,Xiaoyu Li,Wulin Shan et al.
Xu Huang et al.
Background: Ovarian cancer (OC) is the deadliest malignant tumor in the female reproductive system. Sphingolipid metabolism (SM) is crucial for cellular function and has been linked to OC progression. Dysregulation of sphingolipid pathways ...
Mitochondrial Quality Control Systems in Septic AKI: Molecular Mechanisms and Therapeutic Implications [0.03%]
脓毒症急性肾损伤中的线粒体质量控制体系：分子机制和治疗意义
Ying Tan,Yue Ouyang,Zisheng Ma et al.
Ying Tan et al.
Objectives: Despite significant advancements in medical treatments, the creation of a successful treatment strategy for acute kidney injury (AKI) remains a pressing concern. Given the well-documented clinical benefits of canagliflozin in re...
Mechanisms of Huhuang decoction in treating diabetic wounds: a network pharmacological and experimental study [0.03%]
基于网络药理学和实验研究的胡黄连解糖疮疡伤口作用机制探讨
Jie Zhang,Yan Shi,Jiaqiang Wang et al.
Jie Zhang et al.
Background: Huhuang (HH) decoction, a composition of seven traditional Chinese medicines, has demonstrated clinical efficacy in wound healing. However, its pharmacological foundation and potential mechanisms remain unclear. This study aimed...
Danshensu Attenuates Palmitic Acid-Induced Activation of Hepatic Stellate Cells by Regulating Pyroptosis [0.03%]
丹参素通过调节细胞焦亡抑制棕榈酸诱导的肝星状细胞活化
Han-Fang Tseng,Huan-Nung Chao,Chih-Hung Lin et al.
Han-Fang Tseng et al.
Introduction: We focused on examining the role of Danshensu in reducing reactive oxygen species (ROS) production and inhibiting NLRP3 inflammasome activation, which are key factors in liver fibrosis and inflammation. We sought to explore th...
How telomere maintenance affects endometriosis development: a preliminary study [0.03%]
端粒维持对子宫内膜异位症发病的影响：初步研究
Xiaoling Zhao,Weimin Kong,Dan Luo et al.
Xiaoling Zhao et al.
Background: Endometriosis results in dysmenorrhea, dyspareunia, chronic pelvic pain and infertility in reproductive-age women. However, no effective treatment methods have been applied to the disease, and the pathogenesis of endometriosis i...
Gene Signature-Based Prognostic Model for Acute Myeloid Leukemia: The Role of BATF, EGR1, PD-1, PD-L1, and TIM-3 [0.03%]
基于基因特征的急性髓系白血病预后模型：BATF、EGR1、PD-1、PD-L1和TIM-3的作用
Yupei Zhang,Zhixi Chen,Jiamian Zheng et al.
Yupei Zhang et al.
Background: Acute myeloid leukemia (AML) is a malignancy of hematopoietic stem and progenitor cells, with T cell exhaustion linked to poor outcomes. Our previous research has shown that basic leucine zipper ATF-like transcription factor (BA...
Predictors of the Fear of COVID-19 in Individuals with Schizophrenia: a Prospective Study [0.03%]
精神分裂症患者COVID-19恐惧预测因素的一项前瞻性研究
Cheng-Fang Yen,Ching-Shu Tsai,Chien-Wen Lin et al.
Cheng-Fang Yen et al.
Purpose: The fear of COVID-19 can result in psychological distress and mental health problems. Individuals with schizophrenia (IWSs) are especially vulnerable to contracting COVID-19. This study with a 1-year follow-up examined whether indi...
Indoxyl sulfate is associated with cognitive impairment in ESRD patients by activating the extrinsic apoptosis in the neuronal cells during differentiating process [0.03%]
吲哚硫酸盐通过激活神经元细胞分化过程中的外源性凋亡与ESRD患者的认知障碍有关
Chih-Chuan Hsieh,Kuo-Cheng Lu,Chuen-Lin Huang et al.
Chih-Chuan Hsieh et al.
Aim: This study investigates the correlation between indoxyl sulfate (IS) levels and cognitive impairment in end-stage renal disease (ESRD) patients from human study, in vivo and in vitro study. Materials and Methods: Comparison of demograp...
Assessing the Role of Polyamine Metabolites in Blood and the DNA Methylation of Mycobacterium Tuberculosis in Patients with Multidrug-Resistant Tuberculosis [0.03%]
评估代谢产物聚胺在多药耐药结核病患者血液中的作用及聚胺对结核杆菌DNA甲基化的影响
Li Yan,Xinxin Niu,Kuidi Liang et al.
Li Yan et al.
Background: Tuberculosis (TB) is the second largest infectious disease killer in China, and the increasing prevalence of drug-resistant TB patients complicates treatment efforts and raises associated costs. Research on the mechanisms and ch...
Integrated Phenotypic and Transcriptomic Analyses of Osteoporosis in Type 2 Diabetic Mice [0.03%]
2型糖尿病小鼠骨质疏松的表型和转录组综合分析
Shu-Juan Xing,Ying-Feng Gao,Lu Liu et al.
Shu-Juan Xing et al.
Background: Type 2 diabetes (T2D) is a global metabolic condition associated with complications of multiple organs, including the bone. However, the exact impact of T2D on bone along the disease progression, particularly in the early phase,...