Establishing a Risk Prediction Model for Nasopharyngeal Carcinoma Based on Anti-BNLF2b Serological Biomarkers: A Retrospective Study [0.03%]
基于抗BNLF2b血清学生物标志物的鼻咽癌风险预测模型建立：回顾性研究
Hengrong Shao,Mengting Chen,Yufei Xiao et al.
Hengrong Shao et al.
Purpose: This study aims to establish a suitable risk prediction model of NPC in regions with relatively low-incidence in southern China. Methods: We retrospectively analysed the data of 198 patients with NPC and 398 healthy individuals adm...
Heterogeneity of Renal Endothelial Cells, Interact with Neighboring Cells, and Endothelial Injury in Chronic Kidney Disease: Mechanisms and Therapeutic Implications [0.03%]
慢性肾脏病中肾内皮细胞异质性、与邻近细胞相互作用及内皮损伤的机制和治疗意义
Meiyu Zhang,Wu Liu,Haoran Dai et al.
Meiyu Zhang et al.
Chronic kidney disease (CKD) is closely associated with endothelial dysfunction, leading to symptoms such as albuminuria, edema, and coagulopathy. Recent advancements in single-cell sequencing have deepened our understanding of the heteroge...
Risk of Sleep Disorders among Patients with Tourette Syndrome: A Population-Based Cohort Study in Taiwan [0.03%]
台湾一项基于人群的队列研究：抽动障碍患者的睡眠障碍风险
Ning-Jen Chung,Yung-Rung Lai,Yih Yang et al.
Ning-Jen Chung et al.
Background: Tourette syndrome (TS) is a complex neurodevelopmental disorder often linked with various neuropsychiatric comorbidities. This population-based cohort study examined the association between TS and sleep disorders. Materials and ...
Modulation of Chemotherapy Sensitivity of Breast Cancer Cells through Transforming Growth Factor-beta Pathway-mediated Alterations in DNA Damage Response [0.03%]
转化生长因子-β介导的DNA损伤反应变化对乳腺癌细胞化疗敏感性的影响研究
Abdullah S Alhamed,Mohammad S El-Wetidy,Mervat M Abdelwahed et al.
Abdullah S Alhamed et al.
Chemotherapeutic drugs, like cisplatin, function by damaging genomic DNA, thus inducing cell apoptosis. Cancer cells can enhance their DNA repair capacity, leading to chemotherapeutic resistance. Nucleotide excision repair (NER) involves re...
Reduced risk of diabetic retinopathy in osteoarthritis patients undergoing joint replacement surgery [0.03%]
骨关节炎患者接受关节置换手术后糖尿病视网膜病变的风险降低
Chin-Te Huang,Yat-Yin Law,Kai Wang et al.
Chin-Te Huang et al.
Osteoarthritis (OA) is a progressive joint disorder frequently associated with multiple comorbidities. Emerging research suggests a potential link between OA and diabetic retinopathy, a microvascular complication of diabetes mellitus. This ...
Early Hyperbaric Oxygen Therapy Promotes Recovery of Blunt Liver Injury in Rats via Inhibiting Inflammatory Response and Oxidative Stress [0.03%]
早期高压氧治疗通过抑制炎症反应和氧化应激促进肝挫伤大鼠的恢复
Houyu Zhao,Tingting Zhang,Yan Wang et al.
Houyu Zhao et al.
Purpose: Blunt Liver Injury (BLI) is a common form of blunt abdominal trauma, with most cases managed non-surgically in current clinical practice. However, the absence of targeted treatments addressing the pathological changes associated wi...
Yuming Xiao,Zhou Yan,Fangyuan Ren et al.
Yuming Xiao et al.
Bacterial exotoxins are protein- or peptide-based substances secreted by bacteria with high toxicity and specificity. They have diverse mechanisms of action on host cells, leading to host injury by destroying the cellular structure or inter...
Harnessing Oncolytic Viruses for Targeted Therapy in Triple-Negative Breast Cancer [0.03%]
溶瘤病毒在三阴性乳腺癌靶向治疗中的应用
Shasha Tang,Liyun Yong,Yong Cui et al.
Shasha Tang et al.
Breast cancer is the most prevalent malignant tumor among women, with triple-negative breast cancer (TNBC) being one of the most aggressive forms due to its high invasiveness and metastatic potential. Traditional treatments such as endocrin...
Comprehensive Characterization of the Oxidative Stress Profiles in Neonatal Necrotizing Enterocolitis [0.03%]
新生儿坏死性小肠结肠炎氧化应激谱的全面特征分析
Xiaofeng Xiong,Luyao Wu,Xin Liu et al.
Xiaofeng Xiong et al.
Objective: This study aims to portray the characteristics of oxidative stress (OS) in cases of Necrotizing enterocolitis (NEC), identify the hub genes and associated mechanisms involved, and explore potential drugs for NEC. Methods: We perf...
Transcription factor 7-like 2 rs77961654 polymorphism is related to stable angina and acute coronary syndrome in a Chinese population [0.03%]
转录因子7样分子2的rs77961654多态性与中国人稳定型心绞痛和急性冠脉综合征的关系
Teng-Hung Yu,Wei-Hua Tang,Thung-Lip Lee et al.
Teng-Hung Yu et al.
Background: Transcription factor 7-like 2 (TCF7L2) is a key member of the T-cell factor/lymphoid enhancer factor family, and it plays a pivotal role in human physiological processes and has been implicated in various pathological conditions...