Long-term BPV is an Independent Risk Factor for Renal Prognosis in Hypertensive Patients - a Post-hoc Analysis of the SPRINT Study [0.03%]
长期BPV是高血压患者肾脏预后独立危险因素—SPRINT研究的事后分析
Yuyi Ruan,Yutong Chen,Naya Huang et al.
Yuyi Ruan et al.
Background: Long-term blood pressure variability (BPV) reflects fluctuations in BP over time, which may indicate instability in precise blood pressure control. We conducted a post hoc analysis of the data from the SPRINT (Systolic Blood Pre...
Randomized Controlled Trial
International journal of medical sciences. 2025 Apr 22;22(10):2298-2307. DOI:10.7150/ijms.111843 2025
Population Pharmacokinetic-pharmacodynamic Model Analysis of Dapagliflozin for HbA1c-lowering Effects in Japanese Patients with Type 2 Diabetes Mellitus using Long-term Real-world Data [0.03%]
达格列净降低HBA1C的药代动力学-药效学模型在2型糖尿病患者长期真实世界数据中的分析：日本人群
Shinji Kobuchi,Shuhei Sakai,Ryosuke Terada et al.
Shinji Kobuchi et al.
Objectives: Dapagliflozin, a sodium-glucose cotransporter 2 inhibitor, has demonstrated population-level benefits in patients with various metabolic, cardiovascular, and renal comorbidities. However, significant inter-individual differences...
Targeting Tumor Differentiation Grade-related Genes Prognostic Signature Including COL5A1 Based on Single-cell RNA-seq in Gastric Cancer [0.03%]
基于单细胞RNA测序的胃癌分化等级相关基因预后标志物COL5A1等在内的靶向治疗研究
Jianming Wei,Xibo Gao,Zhufeng Li et al.
Jianming Wei et al.
Background: Tumor differentiation grade was reported to be a prognostic factor in gastric cancer (GC). Here, we identify a novel tumor differentiation grade-related genes prognostic signature and provide new biomarkers using single-cell RNA...
Exploring Renin-angiotensin System Genes as Novel Prognostic Biomarkers for Oral Squamous Cell Carcinoma [0.03%]
探究肾素血管紧张素系统基因作为口腔鳞状细胞癌新型预后生物标志物的可能性
Zhengzheng Wu,Can Wang,Jiusong Han et al.
Zhengzheng Wu et al.
Purpose: Recent evidence suggests that the renin-angiotensin system (RAS) is involved in OSCC development. This study aimed to identify RAS-related gene (RASRG) biomarkers associated with OSCC prognosis through integrated bioinformatics ana...
Comparison of Load Distribution in Subperiosteal Implants and Mini Plates in Orthognathic Surgery [0.03%]
正颌手术中骨板与subp种植体分布情况比较研究
Metin Berk Kasapoglu,Zeynep Afra Akbiyik Az
Metin Berk Kasapoglu
Background: Orthognathic surgery is important for correcting craniofacial deformities and restoring occlusion. However, in edentulous patients with severe maxillary atrophy, traditional fixation methods, such as mini plates, may not provide...
Characterizing the gut microbiota composition in Taiwanese hypertensive patients using 16S rRNA sequencing analysis [0.03%]
基于16S rDNA测序分析的台湾高血压患者肠道菌群特征描述
Ming-Shan Chen,Shin-Kuang Jiang,Zhi-Yong Chong et al.
Ming-Shan Chen et al.
Hypertension (HTN) is a significant risk factor for cardiovascular and cerebrovascular diseases. Accumulating evidence suggests a close relationship between HTN and alterations in the gut microbiota composition and abundance. We recruited 2...
Cardiovascular System is Influenced by Skeletal Muscle-derived Extracellular Vesicles, Myokines and MicroRNAs Based on Interorgan Communication: A Systematic Review [0.03%]
基于器官间通讯的骨骼肌来源外泌体、肌细胞因子和微小RNA影响心血管系统：一项系统性综述
Jiaxin Chen,Jingxin Zong,Sha Su et al.
Jiaxin Chen et al.
Background/Aims: To illustrate the types and roles of skeletal muscle-derived bioactive molecules in mediating the communication from skeletal muscle to the heart and blood vessels. Methods: A systematic literature search was performed in f...
Endothelial TIE2 Mutation Induced Contraction Deficiency of Vascular Smooth Muscle Cells via Phenotypic Transition Regulation in Venous Malformations [0.03%]
血管内皮TIE2基因突变通过调节血管平滑肌细胞表型转换致静脉畸形发病的机制研究
Zhong Du,Fan Yu,Yuan He You et al.
Zhong Du et al.
Introduction: Venous malformations (VMs) are congenital vascular malformations characterized by venous cavity enlargement and malformation. Although TIE2 mutation is a recognized genetic landscape in VMs, the regulatory role of TIE2 in vasc...
An Easy-to-Use Risk Stratification System for NSTE-ACS Patients Combining Autonomic Nervous System and Coronary Physiology [0.03%]
结合自主神经和冠状动脉生理的非ST段抬高型急性冠脉综合征患者简便的风险分层系统
Xiaomeng Yang,Zeyan Li,Xinyu Liu et al.
Xiaomeng Yang et al.
Background: The evaluation of autonomic nervous system (ANS) function and coronary physiology through quantitative flow ratio (QFR) analysis provides a precise method for assessing the severity and prognosis of acute coronary syndrome (ACS)...
Circulating short chain fatty acid levels and body composition in type 2 diabetes mellitus [0.03%]
2型糖尿病患者血清中短链脂肪酸水平与体质指数的相关性研究
Ching-Hua Hsu,Yi-Chun Tsai,Ping-Shaou Yu et al.
Ching-Hua Hsu et al.
Background: Short-chain fatty acids (SCFAs) may play key functional roles in the pathophysiology of type 2 diabetes (T2D) through regulating energy intake and substrate metabolism. Body composition, including fat tissue, muscle tissue and t...
Observational Study
International journal of medical sciences. 2025 Apr 22;22(10):2289-2297. DOI:10.7150/ijms.111920 2025