ABCG1 promotes the proliferation and migration of clear cell renal cell carcinoma and reduces its apoptosis [0.03%]
ABCG1促进透明细胞肾细胞癌的增殖和迁移并降低其凋亡
Yihan Dong,Qiufang Qiao,Shaomin Guo et al.
Yihan Dong et al.
Background and Aims: In this study, we analyzed the expression levels of ATP-binding cassette transporter G1 (ABCG1) in clear cell renal cell carcinoma (ccRCC) to assess its significance for early diagnosis and its role in the disease's bio...
Large Language Models in Medicine: Applications, Challenges, and Future Directions [0.03%]
医疗领域中的大型语言模型：应用、挑战与未来方向
Erlan Yu,Xuehong Chu,Wanwan Zhang et al.
Erlan Yu et al.
In recent years, large language models (LLMs) represented by GPT-4 have developed rapidly and performed well in various natural language processing tasks, showing great potential and transformative impact. The medical field, due to its vast...
PDGF-BB/EGR1 Axis Drives Fibroblast Activation Protein Expression to Promote Abdominal Aortic Aneurysm [0.03%]
血小板源性生长因子BB/早期反应基因1轴通过促进纤维活化蛋白表达驱动腹主动脉瘤形成
Zhihao Zhou,Lin Huang,Hui Luo et al.
Zhihao Zhou et al.
This study investigates the molecular mechanisms of fibroblast activation protein (FAP) in vascular smooth muscle cells (VSMCs) during abdominal aortic aneurysm (AAA) development. Bulk and single-cell RNA sequencing analysis revealed elevat...
Deciphering the Relationship Between Circulating Metabolites and Osteoarthritis: A Comprehensive Genetic Correlation and Mendelian Randomization Studies [0.03%]
外周小分子代谢物与骨关节炎遗传相关及孟德尔随机化研究
Guang Yang,Wenqing Xie,Hengzhen Li et al.
Guang Yang et al.
The causal impact of blood metabolites on OA has yet to be definitively established, further studies are needed to explore the specific roles of metabolites in OA. This is a genetic correlation and two-sample bidirectional mendelian randomi...
A Bibliometric Analysis of Neuroinflammation in Depression from 2004 to 2023: Global Research Hotspots and Prospects [0.03%]
2004-2023年抑郁症神经炎症的 bibliometrix 分析：全球研究热点和前景预测
Anni Shi,Na Chen,Qin Ma et al.
Anni Shi et al.
Background: Neuroinflammation lays a prominent impact in the pathophysiology of depression, and numerous studies have been conducted in recent decades. Bibliometric analysis is of important for understanding the hot spots and research trend...
Sijia Liu,Wanqing Zhao,Yusen Qie et al.
Sijia Liu et al.
Grade C periodontitis in young individuals is characterized by its early onset and rapid progression, resulting in swift periodontal tissue destruction in systemically healthy individuals. The application of laser technology in periodontal ...
Doxycycline Enhances Anticancer Activity of Zoledronic Acid via Inducing ROS and Autophagy in Osteosarcoma Cell Lines [0.03%]
多西环素通过诱导ROS和自噬增强唑来磷酸在骨肉瘤细胞系中的抗癌活性
Yi-An Li,Hsuan-Ying Chen,Chien-Sheng Hsu et al.
Yi-An Li et al.
Zoledronic acid (ZOL) is an inhibitor of osteoclast-mediated bone resorption. It is used to treat osteoporosis and skeletal complications in patients with tumor-induced osteolysis. ZOL is also demonstrated to possess anti-cancer activity in...
Associations Between Long-Term Exposure to Air Pollutants and Prostate Cancer in a Large Taiwanese Population [0.03%]
长期暴露于空气污染物与前列腺癌的关联——一项基于台湾大规模人口的研究
Jiun-Hung Geng,Chia-Yang Li,Ming-Tsang Wu et al.
Jiun-Hung Geng et al.
Air pollution is associated with various illnesses including cancers, of which prostate cancer is one of the most prevalent malignancies in men. Emerging evidence has suggested that air pollution is a potential risk factor for prostate canc...
Notable influences of estrogen and sex-specific microenvironment in colorectal cancer revealed by single-cell transcriptome analysis [0.03%]
单细胞转录组分析揭示雌激素和结直肠癌性别特异性微环境的显著影响
Yihui Zheng,Chaoxin Yang,Guozhong Xiao et al.
Yihui Zheng et al.
Background: Colorectal cancer (CRC), the third most common malignancy worldwide, exhibits notable sex-specific prognostic differences, yet the underlying biological mechanisms remain poorly understood. Methods: In this study, we conducted s...
Association of cardiorespiratory fitness with adverse outcomes in patients with and without atrial fibrillation: a prospective cohort study [0.03%]
心肺适能与房颤患者和无房颤患者不良预后的关联：一项前瞻性队列研究
Yutong Wang,Tao Xu,Chenxi Xia et al.
Yutong Wang et al.
Background: Cardiorespiratory fitness plays a crucial role in cardiovascular health; however, its effects on adverse cardiovascular outcomes across different diseases remain poorly defined. Specifically, the differential impact of cardiores...