Statins and Pacing-Induced Atrial Myopathy: Unraveling Their Role in Atrioventricular Block Patients with Permanent Pacemakers [0.03%]
他汀类药物和起搏器诱发的右房心肌病在永久起搏器置入患者的希氏束传导阻滞发生中的作用探讨
Yu-Sheng Lin,Wan-Chun Ho,Meng-Hung Lin et al.
Yu-Sheng Lin et al.
Background: Left atrial (LA) myopathy from interventricular dyssynchrony often precedes atrial fibrillation (AF) in atrioventricular block (AVB) patients with frequent right ventricular (RV) pacing, but the role of statin therapy in prevent...
HK2-mediated Glycolysis Inhibits Mineralization of Cementoblasts Under Compression by Suppressing the Piezo1/Wnt Signaling [0.03%]
HK2介导的糖酵解通过抑制Piezo1/Wnt信号传导来抑制压缩应变下牙槽骨细胞的矿化作用
Zhilong Huang,Hengyu Hu,Ye Meng et al.
Zhilong Huang et al.
Background: Orthodontically induced inflammatory root resorption (OIIRR) is a prevalent and severe complication during orthodontic tooth movement (OTM). Glycolysis plays a crucial role in the inflammatory responses. This study aimed to impr...
Causal Relationship between Gut Microbiota and Endometrial Cancer: A Two-Sample Mendelian Randomization Study [0.03%]
基于孟德尔随机化研究的肠道微生物与子宫内膜癌的因果关系探讨
Xinrui Yao,Sitong Dong,Xiao Li et al.
Xinrui Yao et al.
Several relevant reports have shown that changes in the composition of the gut microbiota are related to the pathogenesis of endometrial cancer (EC). However, the causal effect of the gut microbiota on EC remains unknown. A two-sample Mende...
Long-term Cardiovascular Outcomes in Patients with Omicron COVID-19 and Elevated Cardiac Biomarkers: A Prospective Multicenter Cohort Study in Shanghai, China [0.03%]
上海奥密克戎新冠患者心肌损伤的长期心脏预后：一项前瞻性多中心队列研究
Shun Yao,Yamei Xu,Zhonglei Xie et al.
Shun Yao et al.
Background: The long-term cardiovascular outcomes of SARS-CoV-2 omicron-infected patients remain unclear. This study aimed to evaluate acute and long-term cardiovascular risks in hospitalized omicron-infected patients with elevated cardiac ...
Yinqiao Zhang,Zhaohui Yang,Miao Zhang et al.
Yinqiao Zhang et al.
Myopia, also known as nearsightedness, refers to a refractive error of the eye that causes parallel rays of light to focus in front of the retina, affecting distance vision. High myopia significantly increases the risk of pathological myopi...
Cancer-Associated PIK3R1 Genetic Aberrations and Precision Medicine [0.03%]
PIK3R1基因异常与癌症精确诊断和治疗的关系研究
Huan Xie,Yirong Li,Xinran Li
Huan Xie
The PIK3R1 gene encodes the class IA PI3K regulatory subunit p85α, which is frequently altered in cancer. PIK3R1 functions as a tumor suppressor by stabilizing and inhibiting the catalytic activity of p110, and it directly binds to and enh...
Effect of individualized PEEP titrated by EIT on postoperative atelectasis in children undergoing laparoscopy: A randomized controlled trial [0.03%]
基于EIT指导的个体化PEEP滴定对小儿腹腔镜手术后肺不张的影响：一项随机对照试验
Sheng-Hua Wang,Ye Wang,Si-Yuan Li et al.
Sheng-Hua Wang et al.
Background: Atelectasis is common during perioperative period in children. Although positive end positive end-expiratory pressure (PEEP) has been identified as a lung protective ventilation strategy to alleviate atelectasis, there's still n...
Randomized Controlled Trial
International journal of medical sciences. 2025 Jun 12;22(12):3007-3013. DOI:10.7150/ijms.112280 2025
Ginsenoside Rh7 affects β-catenin nuclear translocation by inhibiting SHCBP1 expression, thereby inhibiting epithelial-mesenchymal transition in gastric cancer cells [0.03%]
Ginsenoside Rh7通过抑制SHCBP1表达影响β-catenin核转位，从而抑制胃癌细胞上皮间质转化
Xiaohong Zhang,Yanqing Mo,Li Feng
Xiaohong Zhang
Background: Ginsenoside Rh7 is a bioactive compound with anticancer properties. This investigation was conducted to analyze the anticancer effects of ginsenoside Rh7 and its underlying molecular mechanisms in gastric cancer (GC) cells. Meth...
Association between Vessels Encapsulating Tumor Clusters and Circulating Tumor Cells in Hepatocellular Carcinoma: Clinical Evidence and Risk Model Development [0.03%]
肝细胞癌包绕肿瘤簇血管与循环肿瘤细胞的关联性：临床证据和风险模型构建
Da-Feng Xu,Rong-Rong Li,Chang Shu et al.
Da-Feng Xu et al.
Background: Vessels encapsulating tumor clusters (VETC) and circulating tumor cells (CTCs) are recognized as emerging potential biomarkers in hepatocellular carcinoma (HCC), yet the underlying connection between them is not fully elucidated...
Observational Study
International journal of medical sciences. 2025 Jun 12;22(12):2944-2955. DOI:10.7150/ijms.111025 2025
Actin-Like Protein 6A as an Oncogene and Therapeutic Target in Cancer [0.03%]
Actin-like蛋白6A作为癌症中的癌基因和治疗靶点
Guo-Bin Song,Lin Xiang,Tian Peng et al.
Guo-Bin Song et al.
ACTL6A, a core subunit of the SWI/SNF chromatin remodeling complex, has emerged as a critical oncogenic driver across multiple malignancies. Recent studies reveal that aberrant ACTL6A overexpression promotes tumor initiation, progression, a...