Progressive Development of Pulmonary Invasive Mucinous Adenocarcinoma With SMARCA4-Deficient [0.03%]
SMARCA4缺陷型肺黏液腺癌的进展及恶化性发展过程
Heng Zheng,Yingying Cui,Fengli Fu et al.
Heng Zheng et al.
SMARCA4-deficient non-small cell lung cancer is characterized by highly aggressive clinical behavior, diverse tumor subtypes, and complex histological features. The application of the SMARCA4 immunohistochemical marker facilitates accurate ...
Case Reports
Pathology international. 2026 Feb;76(2):e70095. DOI:10.1111/pin.70095 2026
Solitary Pulmonary Capillary Hemangioma: Recognition, Clinicopathological Characteristics, and Recent Advances [0.03%]
孤立性肺毛细血管血管瘤的认识、临床病理特征及 recent advances
Hirotsugu Hashimoto
Hirotsugu Hashimoto
Solitary pulmonary capillary hemangioma (SPCH) is a rare, benign nodular lesion composed of proliferating capillaries in the lung. While pulmonary capillary hemangiomatosis-characterized by diffuse or patchy capillary proliferation in the l...
Primary Pulmonary Hyalinizing Clear Cell Carcinoma: Diagnostic Challenges and Pathologic Features in a CT-Guided Biopsy Case [0.03%]
透明细胞黏液样癌的诊断与病理特征：一例经CT引导穿刺活检病例报告
Lipan Wei,Lan Wang,Xiuqian Wu et al.
Lipan Wei et al.
Primary pulmonary hyalinizing clear cell carcinoma (HCCC) is a rare salivary gland-type tumor; most of the cases reported in the literature were diagnosed by surgical resection specimens. Herein, we present a case of pulmonary HCCC diagnose...
Case Reports
Pathology international. 2026 Feb;76(2):e70091. DOI:10.1111/pin.70091 2026
Medullary Thyroid Carcinoma That Progressed From Low- to High-Grade During Treatment: A Case Report [0.03%]
治疗过程中甲状腺髓样癌由低级别进展至高级别的1例报告
Masaomi Sen,Takenori Fujii,Yukako Shintani-Domoto et al.
Masaomi Sen et al.
Medullary thyroid carcinoma (MTC) with high proliferative potential or tumor necrosis is classified as high-grade MTC. Progression from low- to high-grade MTC has rarely been documented. We report a case in which a sporadic MTC transitioned...
Case Reports
Pathology international. 2026 Feb;76(2):e70089. DOI:10.1111/pin.70089 2026
An Autopsy Case of Pleural Mesothelioma Progressed Rapidly With Multiple Organ Metastases During Immune Checkpoint Inhibitor Therapy [0.03%]
一例免疫检查点抑制剂治疗期间胸膜间皮瘤迅速进展伴多器官转移的尸检病例报告
Mihoko Yamamoto-Rikitake,Takeshi Yamaryo,Kazuki Nabeshima et al.
Mihoko Yamamoto-Rikitake et al.
Immune checkpoint inhibitors (ICIs) were approved in Japan in 2021 for the initial treatment of pleural mesothelioma (PM), offering anticipated prognostic benefits. However, reports of atypical responses exist. We report the case of an 80-y...
Case Reports
Pathology international. 2026 Jan;76(1):e70088. DOI:10.1111/pin.70088 2026
Pediatric and Adolescent/Young Adult High-Grade Gliomas With Adult-Type Molecular Features [0.03%]
具有成人型分子特征的儿童及青少年/年轻成人高度胶质瘤患者预后分析
Jyotsna Singh,Supriya Bhardwaj,Swati Singh et al.
Jyotsna Singh et al.
High-grade gliomas (HGGs) in pediatric and adolescent/young adult (AYA) patients are biologically heterogeneous. Most exhibit pediatric-type molecular features, but a subset shows adult-type DNA methylation profiles with distinct diagnostic...
Late-Onset Bilateral Malignant Ciliary Body Medulloepithelioma in an Adult [0.03%]
成人晚期双侧恶性睫状体黑色素上皮细胞瘤
Yuto Kaimi,Shigenobu Suzuki,Toshihide Ueno et al.
Yuto Kaimi et al.
We report the first case of bilateral malignant ciliary body medulloepithelioma (CBME) in an adult, with comprehensive histopathological and genomic analyses. The right eye harbored a malignant teratoid CBME with sarcomatous elements, while...
Extracting Histologic Features to Distinguish Primary and Metastatic Squamous Cell Carcinoma of the Lung [0.03%]
提取组织学特征以区分肺鳞状细胞癌的原发性和继发性病变
Yuri Tachibana,Andrey Bychkov,Kris Lami et al.
Yuri Tachibana et al.
Lung is a common site of metastasis for squamous cell carcinoma (SqCC), and distinguishing primary lung SqCC from pulmonary metastatic SqCC is critical for clinical decision-making, including treatment planning. However, no practical histol...
Pitfall of the Diagnosis of Extramedullary Tumor: A Case of Intracranial Mesenchymal Tumor, FET::CREB Fusion-Positive Occurring in an Atypical Clinical Setting [0.03%]
髓外肿瘤诊断的陷阱：FET::CREB融合阳性 intracranial mesenchymal tumor 不典型的临床表现
Yoshitaka Oda,Yoshinobu Seo,Yosuke Masumoto et al.
Yoshitaka Oda et al.
CD109 Expression in Tumor and Stromal Cells Serves as a Prognostic Biomarker for Tumor Progression and Outcome in Gallbladder Adenocarcinoma [0.03%]
肿瘤和间质细胞中CD109的表达可作为胆囊腺癌进展和预后生物标志物
Taro Kogami,Masaaki Ichinoe,Yasutaka Sakurai et al.
Taro Kogami et al.
CD109 is a glycosylphosphatidylinositol-anchored glycoprotein that is upregulated in various human cancers and exhibits tumor-promoting effects. In this study, we investigated the role of CD109 in gallbladder adenocarcinoma (GBAC). CD109 ex...