Frizzled-9 Expression Is Associated With Aggressive Clinicopathological Features and Reduced Overall Survival in Invasive Breast Carcinoma [0.03%]
Frizzled-9的表达与侵袭性乳腺癌患者的不良病理特征及总生存期缩短有关
Daniel Rodrigues de Bastos,Ricardo Cesar Cintra,Adhemar Longatto-Filho et al.
Daniel Rodrigues de Bastos et al.
The Wnt/Frizzled signaling pathway is implicated in tumor progression, yet the expression patterns and regulatory dynamics of Frizzled class receptor 9 (FZD9) in breast cancer remain poorly defined. This study evaluated FZD9 protein express...
Giant Cell Arteritis With Medin-Derived Amyloid (AMed) Deposition in a Patient With COVID-19: An Autopsy Case [0.03%]
一名COVID-19患者巨细胞动脉炎伴介因衍生淀粉样变（AMed）沉积的尸检病例
Shojiro Ichimata,Tsuneaki Yoshinaga,Mitsuto Sato et al.
Shojiro Ichimata et al.
An 88-year-old man with no past clinical history of polymyalgia rheumatica and symptoms suggestive of giant cell arteritis (GCA), per his family, was found dead outdoors. Antigen testing and real-time PCR confirmed COVID-19 infection. Histo...
Case Reports
Pathology international. 2026 Mar;76(3):e70100. DOI:10.1111/pin.70100 2026
Heterologous Rhabdomyoblastic Differentiation in Dedifferentiated Liposarcoma Is Significantly Associated With Loss of H3K27 Trimethylation [0.03%]
去分化脂肪肉瘤异源性横纹肌样分化与H3K27三甲基化丢失显著相关
Fleur Cordier,Nadine Van Roy,Liesbeth Ferdinande et al.
Fleur Cordier et al.
We identified that H3K27me3 loss appears to be a recurrent event underlying tumor dedifferentiation and heterologous rhabdomyoblastic differentiation in dedifferentiated liposarcoma. Therefore, the loss of H3K27me3 by itself does not provid...
Clinicopathological Features, Cell Membrane and Cytoplasmic Immunostaining of Ki-67 MIB-1 in the Diagnosis of Pulmonary Sclerosing Pneumocytoma [0.03%]
肺硬化性肺瘤的临床病理特征及其Ki-67、MIB-1膜性和胞浆染色的诊断意义
Min Hu,Shiwei Xiao,Xiaowen Li et al.
Min Hu et al.
Pulmonary sclerosing pneumocytoma (PSP) is a rare benign tumor with varied histological morphology. The rarity and morphological heterogeneity of PSP may pose diagnostic challenges for pathologists. In this study, we retrospectively reviewe...
A Case of Prostatic Mixed Germ Cell Tumor Showing Pagetoid Spread Into the Vas Deference in a Patient With Klinefelter Syndrome [0.03%]
克林菲elter综合征患者前列腺混合性生殖细胞肿瘤1例伴瓦瑟曼扩散至输精管现象
Yuki Noto,Akira Satou,Tasuku Kawano et al.
Yuki Noto et al.
Primary germ cell tumors (GCTs) of the prostate are extremely rare in Klinefelter syndrome (KS), with only four cases having been reported. Here, we report a case of mixed GCT characterized by pagetoid spread into the epithelium of the vas ...
Case Reports
Pathology international. 2026 Feb;76(2):e70101. DOI:10.1111/pin.70101 2026
Astrocyte-Glioblastoma Stem Cell Interactions via Extracellular Vesicles Contribute to Distinct Vascular Structures [0.03%]
胶质细胞通过细胞外囊泡与胶质母细胞瘤干细胞相互作用形成不同的血管结构
Yusuke Shirai,Masumi Tsuda,Lei Wang et al.
Yusuke Shirai et al.
Glioblastoma (GBM) is a highly malignant astrocytic tumor characterized by marked heterogeneity and therapeutic resistance. Cancer stem-like cells (CSCs) drive recurrence within specialized microenvironments, such as perivascular niches. Gl...
Transfer Learning Strategies for Pathological Foundation Models: A Systematic Evaluation in Brain Tumor Classification [0.03%]
病理基础模型的迁移学习策略：脑肿瘤分类中的系统评估
Ken Enda,Yoshitaka Oda,Zen-Ichi Tanei et al.
Ken Enda et al.
Deploying pathology AI at individual hospitals faces challenges including limited cases and adapting pretrained models to local data. Brain tumor classification, with diverse diagnostic categories but few cases per institution, represents t...
Immunoreactivities of ZCCHC3 and Efp in the High-Grade Serous and Clear Cell Ovarian Carcinomas Are Worse Prognostic Factors [0.03%]
ZCCHC3和Efp在高级别浆液性和透明细胞卵巢癌中的免疫反应性是更差的预后因素
Erina Iwabuchi,Takashi Suzuki,Kazuhiro Ikeda et al.
Erina Iwabuchi et al.
Ovarian cancer is a prevalent gynecological malignancy among women worldwide, with its high rates of recurrence, metastasis, and mortality, underscoring the need to identify reliable prognostic factors. Recent findings have indicated that z...
Pancreatic Amphicrine Carcinoma With Acinar and Neuroendocrine Differentiation: A Comprehensive Case With Radiological, Cytopathological and Ultrastructural Findings, and Literature Review [0.03%]
具有腺泡和神经内分泌分化的胰腺两栖癌：结合放射学、细胞病理学和超微结构发现的综合病例及文献综述
Hirotsugu Hashimoto,Hajime Horiuchi,Shouichi Satou et al.
Hirotsugu Hashimoto et al.
Amphicrine carcinoma is a rare malignancy exhibiting dual differentiation toward both exocrine and endocrine lineages within the same tumor cells. We report a case of pancreatic amphicrine carcinoma with acinar and neuroendocrine differenti...
Progressive Development of Pulmonary Invasive Mucinous Adenocarcinoma With SMARCA4-Deficient [0.03%]
SMARCA4缺陷型肺黏液腺癌的进展及恶化性发展过程
Heng Zheng,Yingying Cui,Fengli Fu et al.
Heng Zheng et al.
SMARCA4-deficient non-small cell lung cancer is characterized by highly aggressive clinical behavior, diverse tumor subtypes, and complex histological features. The application of the SMARCA4 immunohistochemical marker facilitates accurate ...
Case Reports
Pathology international. 2026 Feb;76(2):e70095. DOI:10.1111/pin.70095 2026