Preanalytical Determinants of DNA and RNA Quality in FFPE Tissues: Practical Recommendations for Molecular Testing [0.03%]
福尔马林固定石蜡包埋组织中DNA和RNA质量的前分析决定因素：分子检测的实际建议
Akiko Kunita,Aya Shinozaki-Ushiku,Sachiyo Nagumo et al.
Akiko Kunita et al.
FFPE tissue is essential for molecular testing, but nucleic acid quality is affected by preanalytical factors. Using porcine models, we systematically examined how formalin concentration, fixation duration, cold ischemia time, and tissue si...
Doublecortin-Like Kinase 1 Expression in HER2-Positive Breast Cancer: Relation to Clinicopathological Characteristics and Response to Subcutaneous Injection of Pertuzumab-Trastuzumab (Phesgo) as a Part of Neoadjuvant Chemotherapy [0.03%]
HER2阳性乳腺癌中双皮层类似物激酶1的表达及其临床病理特征与新辅助化疗中 pertuzumab-trastuzumab（PHESGO）皮下注射疗效的关系分析
Radwa Abd El Moneim Awad,Nehal Abd El-Ghaffar Heabah,Alshimaa Maged Eltawab
Radwa Abd El Moneim Awad
Neoadjuvant therapy is backbone strategy for breast cancer (BC). Neoadjuvant subcutaneous administration of combined Pertuzumab and Trastuzumab (Phesgo) was approved in HER2-positive BC. Pathologic complete response (pCR) to neoadjuvant the...
Eosinophilic Biliary Cystic Neoplasm of the Liver: A Case Report of an Unrecognized Subtype of Intrahepatic Biliary Neoplasm [0.03%]
肝内胆管肿瘤的一个未被认识亚型的病例报告：肝脏嗜酸性胆囊样肿瘤
Mariko Tanaka,Daizo Koinuma,Munetoshi Hinata et al.
Mariko Tanaka et al.
We report a multicystic intrahepatic neoplasm in a 54-year-old Japanese woman, representing a previously unrecognized subtype. Grossly, the lesion was a well-demarcated multicystic tumor with focal papillary projections. Histologically, the...
Case Reports
Pathology international. 2026 Apr;76(4):e70114. DOI:10.1111/pin.70114 2026
Genomic Alteration Patterns Across Histological Grades in BRAF p.V600E-Mutant Gliomas and Glioneuronal Tumors: An Analysis of 15 Cases [0.03%]
BRAF p.V600E突变胶质瘤和胶质神经元肿瘤不同病理分级的基因组改变：对15例患者的研究
Seiji Yamada,Tetsuya Takimoto,Mina Ikeda et al.
Seiji Yamada et al.
BRAF p.V600E-mutant gliomas and glioneuronal tumors comprise a wide clinicopathological spectrum, yet the relationship between genomic alteration burden and histological grade remains incompletely defined. We analyzed 15 BRAF p.V600E-mutant...
Association of Smoothelin, a Cytoskeletal Component of Smooth Muscle Cells, With the Proliferative Features of Uterine Smooth Muscle Tumors [0.03%]
平滑肌细胞细胞骨架成分smoothelin与子宫平滑肌肿瘤增殖特性的关联性研究
Sayaka Shimodai-Yamada,Kenta Uto,Guillaume van Eys et al.
Sayaka Shimodai-Yamada et al.
Smoothelin, a cytoskeletal protein expressed in smooth muscle cells (SMCs), colocalizes with α-smooth muscle actin and is typically restricted to the cytoplasm. Interestingly, in malignant smooth muscle tumors (SMTs), particularly uterine ...
Cortisol-Producing Oncocytic Adrenocortical Carcinoma Harboring a GNAS Mutation: An Integrated Histologic, Ultrastructural, and Genomic Analysis [0.03%]
一种产生皮质醇的伴有GNAS基因突变的 oncocyte 型肾上腺皮质癌：综合组织病理学、超微结构及基因组分析
Naomi Sato,Yuta Tezuka,Taito Itoh et al.
Naomi Sato et al.
Oncocytic adrenal neoplasms are rare adrenocortical tumors characterized by abundant eosinophilic cytoplasm due to massive mitochondrial accumulation. Their biological behavior is often difficult to predict, and various diagnostic systems-i...
Case Reports
Pathology international. 2026 Apr;76(4):e70112. DOI:10.1111/pin.70112 2026
Helicobacter felis-Associated Acute Gastric Mucosal Lesion: Ultrastructure by Low-Vacuum Scanning Electron Microscopy [0.03%]
低真空扫描电镜观察Helicobacter felis相关急性胃黏膜病损的超微结构
Murasaki Aman,Toshihiro Gi,Kazunari Maekawa et al.
Murasaki Aman et al.
This report describes a rare case of acute gastric mucosal lesion associated with H. felis infection. Numerous bacilli were identified within the mucopurulent exudate. The microorganisms were larger, longer, and more tightly coiled than H. ...
Case Reports
Pathology international. 2026 Apr;76(4):e70109. DOI:10.1111/pin.70109 2026
Developmental Odontogenic Cyst With Characteristic Features of Glandular Odontogenic Cyst and Odontogenic Keratocyst [0.03%]
具有腺源性成釉细胞囊肿和成釉细胞瘤特征的发育性牙源性囊肿
Nanako Kataoka,Yasuyuki Asada,Taeko Fukutani et al.
Nanako Kataoka et al.
Spread Through Air Spaces in Colorectal Lung Metastases Signals Local Recurrenece and Reflects Morphologic Aggressiveness of the Primary Tumor [0.03%]
肠癌肺转移灶内经气腔播散预示局部复发并反映了原发肿瘤的恶性程度
Taketo Nakai,Satoru Morita,Yutaka Kurebayashi et al.
Taketo Nakai et al.
Tumor spread through air spaces (STAS) is a histological feature associated with poor prognosis in primary lung cancer, but its relevance in colorectal cancer (CRC) pulmonary metastases remains unclear. This study evaluated the prognostic i...
Appendiceal Goblet Cell Adenocarcinoma With Mismatch Repair Deficiency and Microsatellite Instability-High Status: A Novel Molecular Signature Guiding Immuno-Oncology Strategy [0.03%]
黏蛋白缺陷性错配修复缺陷型阑尾类 goblet cell 腺癌：一种新的分子特征指导免疫治疗策略
Hirotsugu Hashimoto,Hirotomo Koda,Kentaro Nakajima et al.
Hirotsugu Hashimoto et al.
Appendiceal goblet cell adenocarcinoma (GCA) is a rare amphicrine neoplasm, which recent studies have characterized as mismatch repair proficient and microsatellite stable. A 49-year-old male presented to our hospital with a Borrmann type 3...
Case Reports
Pathology international. 2026 Mar;76(3):e70108. DOI:10.1111/pin.70108 2026