George Cavic,Aude M Fahrer
George Cavic
Exploring the dynamics of T-cell responses: a combined approach using EdU incorporation and proliferation dye dilution assay [0.03%]
探索T细胞反应的动力学：结合使用EdU掺入和增殖染料稀释法的综合方法
Hilde Raaphorst,Sinéad Lougheed,Latifa Saou et al.
Hilde Raaphorst et al.
Understanding antigen-specific T-cell responses is crucial for advancing immunotherapies and vaccine development. This study proposes a novel approach combining two complementary assays: the 5-ethynyl-2'-deoxyuridine (EdU) incorporation ass...
Hashemi Vida,Mehranfar Sahar,Amin Nikdouz et al.
Hashemi Vida et al.
Neurodegeneration and neuroinflammation disorders are mainly the result of the deposition of various proteins, such as α-synuclein, amyloid-β and prions, which lead to the initiation and activation of inflammatory responses. Different che...
Innovations in Immunology Education: bridging theory, practice and professional development [0.03%]
免疫学教育创新——理论、实践及职业发展的融合
Samy Sakkal,Maurizio Costabile
Samy Sakkal
Cyril Seillet,Le Xiong
Cyril Seillet
A recent article has shown that blocking NKp46 signaling reduces injury, highlighting these cells as key drivers of organ damage and potential therapeutic targets in autoimmune diseases. In lupus nephritis, NKp46+ ILC1s orchestrate kidney i...
Antigen presentation of post-translationally modified peptides in major histocompatibility complexes [0.03%]
经翻译后修饰的肽类在主要组织相容性复合物中的抗原呈递
Alexine S de Wit,Frans Bianchi,Geert van den Bogaart
Alexine S de Wit
T cells of the adaptive immune system recognize pathogens and malignantly transformed cells through a process called antigen presentation. During this process, peptides are displayed on major histocompatibility complex (MHC) class I and II ...
Eduardo J Villablanca
Eduardo J Villablanca
Role models play a crucial role in inspiring and guiding careers in science, offering tangible examples of success and resilience. Reflecting on my journey from a small town in southern Chile to leading a lab at Karolinska Institutet, I've ...
RNAi library screening reveals Gβ1, Casein Kinase 2 and ICAP-1 as novel regulators of LFA-1-mediated T cell polarity and migration [0.03%]
RNA干扰文库筛选发现Gβ1、蛋白激酶CK2和ICAP-1是T细胞极化和迁移的新调节因子
Antje Haap-Hoff,Michael Freeley,Eugene Dempsey et al.
Antje Haap-Hoff et al.
The αLβ2 integrin LFA-1 plays a key role in T-cell adhesion to the endothelial vasculature and migration into both secondary lymphoid organs and peripheral tissues via interactions with its target protein ICAM-1, but the pathways that reg...
The future of scientific labs: how we are making our research more sustainable [0.03%]
科研的未来：我们是如何让研究工作更可持续发展的？
Ebony A Monson,Stephanie Rutter,Christopher C Reimann et al.
Ebony A Monson et al.
The need for climate action is becoming increasingly urgent, and research labs need to be part of the solution. Scientific labs consume large amounts of energy and water and produce significant waste. Globally, scientific research generates...
Céline Pattaroni
Céline Pattaroni
In this article, we discuss a recently published study by Gopee et al., who have unveiled a surprising role for macrophages in human prenatal skin development, extending far beyond their traditional immune function. By constructing a compre...