Myeloid cell recruitment and activation through systemic and mucosae-directed cytokine therapy [0.03%]
通过全身和黏膜靶向细胞因子治疗募集并激活髓系细胞
Cordelia Manickam,Rhianna Jones,Nihar R Deb Adhikary et al.
Cordelia Manickam et al.
Myeloid cells play critical roles as Fc effector cells in antibody-mediated immunity. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic cytokine that promotes the recruitment and activation of multiple myeloid popul...
Immunopathology of optic neuritis and cerebrospinal fluid biomarkers for acute attack and relapse prediction [0.03%]
视神经炎的免疫病理及预测急性发作和复发的脑脊液生物标志物
Rong Jin,Shihao Sun,Xiangyi Liu et al.
Rong Jin et al.
Optic neuritis (ON), characterized by inflammation and demyelination of the optic nerve, is a leading cause of vision impairment. It frequently manifests as the initial symptom and a recurrent syndrome in patients with myelin oligodendrocyt...
Microbe-responsive human γδ T cells: the peculiar case of Staphylococcus aureus [0.03%]
对人的γδT细胞的微生物响应：金黄色葡萄球菌的特殊案例
Matthias Eberl,Manuel Mata Forsberg,James E McLaren et al.
Matthias Eberl et al.
Vγ9/Vδ2 T cells represent the largest γδ T-cell population in human blood and possess a unique responsiveness towards microbial organisms by sensing the metabolite (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP) in the context ...
PI3K GOF leads to dysregulation of T and B cells that both contribute to extrinsically driving activation and differentiation of other CD4+ T cells [0.03%]
PI3K 基因过度激活导致T细胞和B细胞调节异常，二者协同促发其他CD4+T细胞的活化与分化
Julia Bier,Anthony Lau,Katherine Jl Jackson et al.
Julia Bier et al.
Activated PI3K delta syndrome 1 (APDS1) is caused by a heterozygous germline gain-of-function (GOF) variant in PIK3CD, which encodes the p110δ catalytic subunit of phosphoinositide 3-kinase (PI3K). APDS1 patients display a broad range of c...
Jessica G Borger,Danica Hickey,Jennifer R Habel et al.
Jessica G Borger et al.
Early career researchers (ECRs) are often faced with uncertainty about their professional futures, a challenge exacerbated by the increasing pressures within the academic research landscape. As ECRs navigate their next steps in science, men...
Effect of methyl DNA adducts on stimulation of human cytoplasmic DNA-sensor cyclic GMP-AMP synthase (cGAS) [0.03%]
甲基-DNA加合物对人胞质DNA传感器cGAS的激活作用
Nikhil Tuti,Sharan Shanmuga Vuppaladadium Rathnam,Jitender Jangra et al.
Nikhil Tuti et al.
The immune system uses a variety of DNA sensors, including endo-lysosomal Toll-like receptors 9 (TLR9) and cytosolic DNA sensor cyclic GMP-AMP (cGAMP) synthase (cGAS). These sensors activate immune responses by inducing the production of a ...
Mechanism of CD83 expression induction through dectin-1 and β-glucan interaction in innate immune responses [0.03%]
先天性免疫反应中通过Dectin-1和β-葡聚糖相互作用诱导CD83表达的机制
Naoki Arima,Tsuyoshi Kato,Takashi Kanno et al.
Naoki Arima et al.
This study assessed how the interaction between human monocyte dectin-1 and β-glucan induces CD83 expression using THP-1 cells as a model. Flow cytometry and enzyme-linked immunosorbent assay (ELISA) were used to assess the dynamics of mem...
Modeling the response to interleukin-21 to inform natural killer cell immunotherapy [0.03%]
建立细胞对白细胞介素-21的反应模型以指导自然杀伤细胞免疫疗法
Indrani Nayak,Rosalba Biondo,William C Stewart et al.
Indrani Nayak et al.
Published Erratum
Immunology and cell biology. 2025 Aug 15. DOI:10.1111/imcb.70055 2025
Tyro3 deletion is protective in experimental autoimmune encephalomyelitis [0.03%]
泰克斯汀3型缺失能对抗实验性自身免疫性脑脊髓炎
Michele D Binder,Mohammad Asadian,Darnell Leepel et al.
Michele D Binder et al.
Multiple sclerosis is a complex neurological disorder, involving both the adaptive and innate immune systems as well as the CNS. The interaction between these systems is complex, and as such, there is the potential for MS therapies to have ...
Adsorption of antigen to polymeric nanoparticles enhances cytotoxic T-cell responses and anti-tumor immunity by targeting conventional type 1 dendritic cells [0.03%]
抗原吸附到聚丙烯颗粒通过靶向常规I型树突细胞来增强细胞毒性T细胞反应和抗肿瘤免疫
Jorge Huete-Carrasco,Jingjing Zhu,Benoit J Van den Eynde et al.
Jorge Huete-Carrasco et al.
Tumor rejection is primarily mediated by cytotoxic T cells, making them critical targets for therapeutic cancer vaccines. Vaccine adjuvants can modulate innate immunity, influencing adaptive immune responses. For particulate adjuvants, such...