Jasmine G Hughes
Jasmine G Hughes
Over the years, beginning with my undergraduate lab experiences, I became aware of the traits essential for success in academic study and research. The traits, which I refer to as the "S Triple G Traits" are Support, Growth mindset, Grit an...
A potential role for monoallelic expression in penetrance of autosomal dominant inborn errors of immunity [0.03%]
常染色体显性遗传先天性免疫缺陷病的外显率中单等位基因表达的潜在作用
Emily Sj Edwards,Menno C van Zelm
Emily Sj Edwards
In this article, we discuss a recent study, where autosomal monoallelic expression of genes underlying Inborn Errors of Immunity were investigated. About 2-10% of genes are predominantly transcribed from a single allele leading to autosomal...
ALDOB suppresses the activity of CD8+ T cells in colorectal cancer via the WNT signaling pathway [0.03%]
ALDOB通过WNT信号通路抑制结直肠癌中CD8+T细胞活性
Jinwei Liu,Chao Hu,Yuan Jin
Jinwei Liu
The glycolytic enzyme, fructose-1,6-bisphosphate aldolase B (ALDOB), is recognized for its key role in shaping tthe umor immune microenvironment. However, the precise ways in which it influences the CD8+ T cell immune response in colorectal...
Global perspectives to enhance strategies for advancing women in healthcare and STEMM leadership [0.03%]
全球视角下的策略改进以促进女性在医疗卫生和STEMM领导地位上的发展
Jessica G Borger,Rhea J Longley,Megan F Taylor et al.
Jessica G Borger et al.
The discourse surrounding gender equity has intensified recently, amplified by the impacts of the COVID-19 pandemic, highlighting the critical underrepresentation of women in leadership roles across various sectors including the media and h...
Modeling the response to interleukin-21 to inform natural killer cell immunotherapy [0.03%]
建立对白细胞介素-21的反应模型以指导自然杀伤细胞免疫疗法
Indrani Nayak,Rosalba Biondo,William C Stewart et al.
Indrani Nayak et al.
Natural killer (NK) cells are emerging agents for cancer therapy. Several different cytokines are used to generate NK cells for adoptive immunotherapy including interleukin (IL)-2, IL-12, IL-15 and IL-18 in solution, and membrane-bound IL-2...
The cyclin-dependent kinase inhibitor AT7519 is a human RORγt agonist [0.03%]
Cyclin依赖性激酶抑制剂AT7519是人RORγt激动剂
Kaja Karaś,Joanna Pastwińska,Anna Sałkowska et al.
Kaja Karaś et al.
AT7519, which inhibits multiple cyclin-dependent kinases, has been extensively investigated in various types of cancer cells. Previous studies have demonstrated the ability of this molecule to suppress the expression of the nuclear receptor...
ADAM10 modulates the efficacy of T-cell mediated therapy in solid tumors [0.03%]
ADAM10调节T细胞介导的固体肿瘤治疗的功效
Ahmed Me Abdalla,Yu Miao,Ning Meng et al.
Ahmed Me Abdalla et al.
Published Erratum
Immunology and cell biology. 2025 Jan 20. DOI:10.1111/imcb.12855 2025
Sara Berent,Rhys S Allan
Sara Berent
In this Research Highlight, we discuss recent research which shows that TCR-mediated activation and NF-κB signalling play an indispensable role in localising Xist RNA and its interactors to the inactive X chromosome (Xi) in T cells (left a...
Penny Hawkins,James Dooley,Jessica Rodda et al.
Penny Hawkins et al.
This report presents findings from a group of UK-based researchers with expertise in the use of animal models for bone marrow ablation and reconstitution. The primary aim is to facilitate the implementation of the Three Rs (Replacement, Red...
Learnings from ten years away from "home" as a South American immunologist in Ireland [0.03%]
一位南美免疫学家在爱尔兰十年的感悟远离故土的心理路程
Natalia Muñoz-Wolf
Natalia Muñoz-Wolf
Pursuing an international scientific career is a fantastic opportunity for personal and professional growth, but it also poses unique challenges, which can be particularly daunting for researchers coming from resource-limited countries. Dra...