Highlights of 2024: The multifaceted roles of ILC3s in mucosal immunity and inflammation [0.03%]
2024年度亮点：ILC3s在黏膜免疫和炎症中的多重作用
Xin Shen,Xianzhi Gao,Lie Wang
Xin Shen
In this article for the Highlights of 2024 Series, we discuss research on Group 3 innate lymphoid cells (ILC3s), which revealed their complex roles in mucosal immunity and inflammation. ILC3s can migrate from the gut to the kidneys, contrib...
B cells regulate somatic hypermutation rate to preserve high-affinity clones [0.03%]
B细胞调控体细胞高频突变率以保留高亲和力克隆簇
Pradhnesh Andhare,Brian J Laidlaw
Pradhnesh Andhare
In this Research Highlight, we discuss two recently published studies that show that germinal center B cells undergoing multiple rounds of cell division strongly suppress their rate of somatic hypermutation. These studies provide an explana...
Breaking down barriers with sensory science-improving accessibility to neuroimmunology for the blind and low-vision communities [0.03%]
运用感官科学突破壁垒改善盲人和低视力人群接触神经免疫学的机会
Stavroula Piliou,Jasmine G Hughes,Stepanka Facerova et al.
Stavroula Piliou et al.
Scientific public engagement activities and participation in bioscience discussions need to be open to everyone, as they play a significant role in connecting the general public to research and breaking down barriers of scientific skepticis...
Causal relationship between immune cells, metabolites and polycystic ovary syndrome identified by Mendelian randomization and mediation analyses [0.03%]
孟德尔随机分析和中介分析鉴定免疫细胞、代谢产物与多囊卵巢综合症的因果关系
Lan Li,Yang Mo,Ximing Yu et al.
Lan Li et al.
Immune cells and blood metabolites play essential roles in the development of polycystic ovary syndrome (PCOS); however, it remains unclear whether blood metabolites mediate the causal relationship between immune cells and PCOS. This study ...
Plasmodium falciparum and immune phagocytosis: characterization of the process [0.03%]
恶性疟原虫和免疫吞噬作用：对这一过程的描述
Dia Aldeen Alfaki,Mohamed Mubarak Elbasheir
Dia Aldeen Alfaki
Phagocytosis is a critical immunological process that enables the immune system to recognize and eliminate foreign pathogens and self-derived pathogenic molecules. Improving the overall understanding of this immune mechanism during malarial...
Highlights of 2024. Broadening anti-cancer immunotherapy modalities with antibody-drug conjugates: emerging insights from clinical studies [0.03%]
2024年亮点。通过抗体药物偶联物扩展抗癌免疫治疗方式：临床研究中的新兴见解
Jiya Jose,John D Hooper,Fernando Souza-Fonseca-Guimaraes
Jiya Jose
In this article for the "Highlights of 2024" series, we discuss antibody-drug conjugates (ADCs), which are an emerging class of targeted cancer therapies that harness the specificity of monoclonal antibodies to deliver cytotoxic agents dire...
Matthias Eberl
Matthias Eberl
In this manuscript for the "Highlights of 2024" series, this is me trying to summarize recent discoveries regarding the emerging regulatory and effector roles of γδ T cells during sepsis, both in human patients and in mouse models. The ne...
Highlights of 2024: Cytokines and ligands modulating NK cell effector functions [0.03%]
2024年亮点：调节NK细胞效应功能的细胞因子和配体
Aneena Mary Shajan,Louisa Alim,Fernando Souza-Fonseca-Guimaraes
Aneena Mary Shajan
In this article for the "Highlights of 2024" Series, we discuss natural killer cells, which are essential players in immune defense, with their function tightly regulated by cytokines and ligand-receptor interactions. We discuss important r...
Increased fatty acid production and macrophage-driven inflammation as key drivers of severe respiratory disease [0.03%]
脂肪酸产量增加和巨噬细胞驱动的炎症是严重呼吸系统疾病的关键驱动因素
Emily M Eriksson,Ivo Mueller
Emily M Eriksson
In this article, we discuss a recent article by Jia et al., where high OLAH expression was detected in severe and fatal respiratory disease which was associated with a number of processes and responses. These include high abundance of oleic...
Advancing equity and inclusion in healthcare and STEMM: an immunological call to action [0.03%]
在医疗和STEMM领域推进公平与包容性：一项免疫学行动呼吁
Jessica G Borger
Jessica G Borger
Scientists and researchers represent a broad diversity of genders, races, and abilities, emphasising the importance of intersectionality in healthcare and STEMM. However, with diversity come systemic barriers that must be addressed to achie...