Heterogeneity of T follicular regulatory cells: exploring their expanding ontogeny and differentiation pathways [0.03%]
生发中心调节性T细胞的异质性：探索其不断扩增的起源和分化途径
Maria Miguel Cavaco,Pedro Gaspar,Rui do Amaral Vieira et al.
Maria Miguel Cavaco et al.
T follicular regulatory (Tfr) cells have emerged as key mediators in controlling germinal center (GC) responses, preventing excessive immune activation and preserving self-tolerance. Initially thought to originate solely from thymic T regul...
Maria Rosa Bono,Fabiola Osorio
Maria Rosa Bono
The field of immunology in Chile has evolved remarkably over the past few decades, from a nascent discipline to a dynamic and rapidly developing community with significant international visibility. In this commentary, we, Fabiola Osorio and...
Highlights of 2024: Tregs immunometabolism and how to counter inflammatory niches [0.03%]
2024年亮点：Tregs免疫代谢及对抗炎症生态位的方法
Nicolas Valentini,Christopher J Requejo Cier,Caroline Lamarche
Nicolas Valentini
In this article for the Highlights of 2024 Series, we discuss recent discoveries in Treg immunometabolism, which reveal how inflammatory niches alter Treg fate and function through distinct metabolic cues. Key findings include IL-21-driven ...
Are single nucleotide polymorphisms underutilized for guiding treatment of inflammatory bowel disease? [0.03%]
单核苷酸多态性是否被低估了在指导炎症性肠病治疗中的作用？
Jildou van der Werf,Nicholas Ian Fleming
Jildou van der Werf
Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD), ulcerative colitis (UC) and IBD unclassified (IBDU), significantly impacts quality of life. Despite significant advances in the management of the conditions, responses to ...
Highlights of 2024: Beyond lipids: immune dysfunction in APOE4-associated Alzheimer's disease [0.03%]
2024年亮点：超越脂质：APOE4相关阿尔茨海默病中的免疫功能障碍
Isabella McEwan,Shannon Thomson,Jasmeen K Issar et al.
Isabella McEwan et al.
In this article for the "Highlights of 2024" Series, we discuss findings by our group and others that the Alzheimer's disease (AD) risk genetic variant apolipoprotein E ε4 (APOE4) is associated with peripheral immune dysregulation and chro...
Highlights of 2024: The rising role of age-associated B cells in autoimmune diseases [0.03%]
2024年亮点：年龄相关B细胞在自身免疫疾病中作用的上升
Adrian Ys Lee,Joanne H Reed
Adrian Ys Lee
In this Research Highlight, we explore 5 influential basic and translational articles published in 2024 that shed light on the biology of age-associated B cells (ABCs) and their emerging role in autoimmunity. ...
Ajitha Thanabalasuriar
Ajitha Thanabalasuriar
The path to becoming an academic researcher is winding. The trajectories and landscapes of academic success may mean many different things to each of us. There is no clear or direct path anymore. Here, I share with you my journey, giving im...
Highlights of 2024: New insights into the molecular regulation of antibody-secreting cells and their subsets [0.03%]
2024年度亮点回顾：抗体分泌细胞及其亚群分子调控的新见解
Michael James Flaman,KimAnh Trang Pioli,Peter Dion Pioli
Michael James Flaman
Collectively, 2024 has significantly increased the wealth of knowledge regarding antibody-secreting cell heterogeneity in health and disease. This 'Highlights of 2024' article discusses key studies contributing to the understanding of how t...
Touching the invisible: exploring intracellular host-pathogen interactions through multisensory art [0.03%]
触摸无形：通过跨感官艺术探索胞内宿主-病原体相互作用
Rachel Elizabeth Jackson,Georgia Miller,Rachel Weild et al.
Rachel Elizabeth Jackson et al.
The microscopic world of intracellular bacteria is rarely communicated to non-scientists. By participating in the Sensory Science Exhibition, held at St Catharine's College, University of Cambridge as part of the Cambridge Festival, we soug...
A new method to measure cell metabolism of rare cells in vivo reveals a high oxidative phosphorylation dependence of lung T cells [0.03%]
一种新的活体稀有细胞代谢检测方法显示肺部T细胞具有较高的线粒体呼吸依赖性
Aristeidis Roubanis,Morgane Hilaire,Morgane Le Teuff et al.
Aristeidis Roubanis et al.
Regulation of cellular metabolism is a central element governing the fate and function of T cells. However, the in vivo metabolic characteristics of rare cells, such as nonlymphoid tissue T cells, are poorly understood because of experiment...