Targeting glutamine metabolism in CD4+ T-cell-mediated autoimmune diseases [0.03%]
靶向胶质酸代谢治疗CD4⁺T细胞介导的自身免疫病
Zheng Li,ZeHong Su,ZhiMin Wu et al.
Zheng Li et al.
CD4+ T cells play a vital role in the occurrence and development of autoimmune diseases (AID). The differentiation direction and function of CD4+ T cells are both regulated by metabolic reprogramming, which differs across various CD4+ T sub...
Joanne H Reed
Joanne H Reed
Serum proteomic and metabolomic analyses from patients with IBD identify biological pathways associated with treatment success with anti-integrin therapy [0.03%]
来自IBD患者血清的蛋白质组和代谢组分析确定了与抗整合素治疗成功相关的生物学通路
John D Rioux,Gabrielle Boucher,Anik Forest et al.
John D Rioux et al.
Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases of the gastrointestinal tract believed to arise from an imbalance between its epithelial, immune and microbial components. It has been shown that biological ...
Interferon signaling in type-2 dendritic cells supports TH2 and T follicular helper fates in response to allergens [0.03%]
干扰素在2型树突状细胞中信号传导支持TH2和TFH命运以响应过敏原
Greta R Webb,Kerry L Hilligan,Sam I Old et al.
Greta R Webb et al.
Type-2 dendritic cells (DC2s) are essential for the initiation of type-2 immune responses, but the signaling pathways involved in allergen sensing, DC activation and instruction of CD4+ T cell differentiation into TH2 cells remain unclear. ...
Highlights of 2024: unleashing the power of NK cells-cancer's worst nightmare [0.03%]
2024年度亮点：NK细胞的威力——癌症的噩梦
Capucine Bourel,Fernando Souza-Fonseca-Guimaraes,Sylvie Lesage
Capucine Bourel
In this article for the Highlights of 2024 Series, we discuss strategies to enhance NK cell-based cancer therapies. These include (1) cytokine expression on bacterial membranes to boost NK cell activation in tumors, (2) optimizing CAR-NK ce...
Jordan Kramer,P Anton van der Merwe,Omer Dushek
Jordan Kramer
Immune cells interact directly with other cells and make decisions by integrating information from many different receptor-ligand interactions at these cell-cell interfaces. Since they encounter a huge variety of normal and abnormal cells, ...
Alex Johnston,Arti Medhavy,Suzanne Elliott et al.
Alex Johnston et al.
Founded in 2005, Gallipoli Medical Research (GMR) is a leading independent medical research institute located in Greenslopes, Brisbane, Queensland. GMR strives to enrich and restore lives through pioneering medical research that transcends ...
Cassandra J McGill,Olivia S White,Ryan J Lu et al.
Cassandra J McGill et al.
Macrophages are a key cell type of the innate immune system and are involved at all steps of inflammation: (i) they present antigens to initiate inflammation, (ii) they clear up foreign bodies through phagocytosis and (iii) they resolve inf...
Theresa E Pankhurst,Michelle A Linterman
Theresa E Pankhurst
In this article for the Highlights of 2024 series, we review the latest advances in the biology of the germinal center response. These discoveries provide key insights into germinal center function and dysregulation, uncovering new opportun...
Transcriptomic signatures of host immune responses in aphthous ulcers, the earliest lesions of Crohn's disease, suggest that bacterial uptake, rather than global dysbiosis, is the initiating factor [0.03%]
阿夫特溃疡（克罗恩病最早期的病变）转录组标志显示，细菌摄取是始动因素，而非整体失调因素
Phillip J Whiley,Ojas Va Dixit,Mukta Das Gupta et al.
Phillip J Whiley et al.
Crohn's disease is a chronic, transmural inflammatory disease of the human gut. Changes in the fecal microbial composition and dysbiosis are consistent features in studies of Crohn's disease patients, but whether dysbiosis is a cause or con...