Gross saponins of Tribulus terrestris attenuate rheumatoid arthritis by promoting apoptosis of fibroblast-like synoviocytes and reducing inflammation by inhibiting MAPK signalling pathway [0.03%]
蛮荆皂苷通过促进滑膜细胞凋亡和抑制MAPK信号通路减少炎症来减轻类风湿性关节炎
Xinghai Cheng,Yuantao Su,Ningzheng Dong et al.
Xinghai Cheng et al.
Among the numerous treatment options for rheumatoid arthritis (RA), the promotion of synoviocyte apoptosis and inhibition of inflammation are considered the most effective. However, the potential pro-apoptotic effects of gross saponins of T...
Regulatory mechanism of TRIM21 in sepsis-induced acute lung injury by promoting IRF1 ubiquitination [0.03%]
TRIM21通过促进IRF1泛素化在调节脓毒症诱导的急性肺损伤中的机制
Wenjie Ma,Jie Zheng,Bin Wu et al.
Wenjie Ma et al.
Sepsis-induced acute lung injury (ALI) is characterized by inflammatory damage to pulmonary endothelial and epithelial cells. The aim of this study is to probe the significance and mechanism of tripartite motif-containing protein 21 (TRIM21...
AEBP1 restores osteoblastic differentiation under dexamethasone treatment by activating PI3K/AKT signalling [0.03%]
糖皮质激素作用下,AEBP1通过激活PI3K/Akt信号恢复成骨分化
Rilong Jin,Chen Li,Yute Yang et al.
Rilong Jin et al.
Adipocyte enhancer-binding protein 1 (AEBP1) is closely implicated in osteoblastic differentiation and bone fracture; this research aimed to investigate the effect of AEBP1 on restoring osteoblastic differentiation under dexamethasone (Dex)...
Agomelatine-loaded nanostructured lipid carriers alleviate neuropathic pain in rats by Nrf2/HO-1 signalling pathway [0.03%]
载阿戈美拉汀纳米结构脂质载体通过Nrf2/HO-1信号通路缓解大鼠神经痛
Sundas Firdoos,Rongji Dai,Zahid Younas et al.
Sundas Firdoos et al.
Neuropathic pain arises from impairments or malfunctions within the nervous system, resulting in atypical transmission and interpretation of pain signals. In the present study, we examined the neuroprotective effects of agomelatine (AGM) an...
Propofol attenuates prostate cancer progression by upregulating TRHDE-AS1 expression, and METTL14 could mediate its m6A modification [0.03%]
异丙酚通过上调TRHDE-AS1表达抑制前列腺癌进展，METTL14介导其m6A修饰
Zhuo Chen,Quanfu Li,Zhong Li et al.
Zhuo Chen et al.
Propofol has become a microtubule-stabilizing drug for prostate cancer (PC) therapy, but propofol resistance impairs the therapeutic effect. This study aimed to explore the regulatory mechanism of propofol in the pathogenesis of PC through ...
Phillygenin attenuates cell apoptosis and microglia activation in cerebral ischaemia-reperfusion rats through activation of peroxisome proliferator-activated receptor γ [0.03%]
Phillygenin通过激活过氧化物酶体增殖活化受体γ减轻脑缺血再灌注损伤大鼠神经元凋亡及微胶质细胞活化
Chaojun Yan,Guangwei Sun,Changlong Hu et al.
Chaojun Yan et al.
Ischaemic stroke is a common condition that can lead to cerebral ischaemia-reperfusion injury. Phillygenin (PHI), a natural bioactive compound derived from Forsythia suspensa, has been shown to play a crucial role in regulating inflammation...
High-sensitivity C-reactive protein to high-density lipoprotein cholesterol ratio predicts long-term adverse outcomes in patients who underwent percutaneous coronary intervention: A prospective cohort study [0.03%]
高敏C反应蛋白与高密度脂蛋白胆固醇比值对经皮冠状动脉介入治疗患者长期预后的预测价值：前瞻性队列研究
Xin-Ya Dai,Zheng-Kai Xue,Xiao-Wen Wang et al.
Xin-Ya Dai et al.
High-sensitivity C-reactive protein (hsCRP) to high-density lipoprotein cholesterol (HDL-C) ratio (CHR) is associated with coronary artery disease (CAD), but its predictive value for long-term adverse outcomes in patients with CAD following...
Adenylate cyclase 1 knockdown attenuates pirarubicin-induced cardiotoxicity [0.03%]
腺苷酸环化酶1敲低减轻平阳霉素诱导的心脏毒性
Wenqing Zhang,Zhiyun Shu,Peng Huang et al.
Wenqing Zhang et al.
This study aimed to investigate the effects and possible mechanisms of adenylate cyclase 1 (ADCY1) on pirarubicin-induced cardiomyocyte injury. HL-1 cells were treated with pirarubicin (THP) to induce intracellular toxicity, and the extent ...
β-Adrenergic receptor signalling pathway mediated antiarrhythmic activity of s-limonene in the rat heart [0.03%]
L-柠烯介导β-肾上腺素受体信号通路在大鼠心脏抗心律失常作用
Joyce Francielle Ferreira Santos,Diego Santos de Souza,Karina Oliveira Mota et al.
Joyce Francielle Ferreira Santos et al.
S-Limonene (s-Lim) is a monocyclic monoterpene found in a variety of plants and has been shown to present antioxidant and cardioprotective activity in experimental models of myocardial infarction. The aim of this study was to evaluate the p...
Rapid detection of guttae area using aniline blue staining in Fuchs endothelial corneal dystrophy mouse model [0.03%]
苯胺蓝染色在Fuchs角膜内皮营养不良小鼠模型中快速检测滴状物面积
Xueling Zhang,Jini Qiu,Yalan Feng et al.
Xueling Zhang et al.
Fuchs endothelial corneal dystrophy (FECD) is a leading cause of corneal endothelial degeneration resulting in impaired visual acuity. Excessive deposition of extracellular matrix (guttae) on Descemet's membrane (DM) is the hallmark of FECD...