Corticosterone-Induced Myocardial Dysfunctions and the Cardioprotective Role of Tauroursodeoxycholic Acid: An Experimental Study in Mice [0.03%]
糖皮质激素致小鼠心功能障碍及熊去氧胆酸氨基化合物的心脏保护作用：实验研究
Houyuan Zhou,Xiaoying Chen,Yanlin Tao et al.
Houyuan Zhou et al.
Background: Major depressive disorder increases cardiovascular risk through stress-induced elevated cortisol levels. Tauroursodeoxycholic acid (TUDCA), a bile acid, has been reported to have anti-inflammatory, anti-depres...
NSUN3 Aggravates Sepsis-Associated Acute Kidney Injury by Stabilising TIFA mRNA Through m5C [0.03%]
NSUN3通过m5C稳定TIFA mRNA从而加剧脓毒症相关急性肾损伤
Chenran Zhang,Wenming Shen,Xuwen Zheng et al.
Chenran Zhang et al.
Background: Acute kidney injury (AKI) is a common complication of sepsis and also a risk factor for progression of chronic kidney disease. NOP2/Sun RNA methyltransferase 3 (NSUN3) is involved in the regulation of sepsis p...
PHD3-Mediated Inhibition of Retinal Neovascularization in Retinopathy of Prematurity [0.03%]
PHD3介导的早产儿视网膜病变新生血管抑制作用
Jiawei Yu,Haifeng Liu,Yue Xing et al.
Jiawei Yu et al.
Retinopathy of prematurity is characterised by abnormal retinal neovascularization in response to hypoxia stress. Prolyl 4-hydroxylase domain protein 3 (PHD3) is a well-known molecular oxygen sensor. However, the role that PHD3 plays in ret...
Isoferulic Acid Inhibits Proliferation and Migration of Pancreatic Cancer Cells, and Promotes the Apoptosis of Pancreatic Cancer Cells in a Mitochondria-Dependent Manner Through Inhibiting NF-κB Signalling Pathway [0.03%]
异茋酸通过抑制NF-κB信号途径以线粒体依赖的方式促进胰腺癌细胞凋亡及抑制增殖和迁移的作用研究
Suqin Sun,Rong Fan,Li Chang et al.
Suqin Sun et al.
Isoferulic acid (IA), a derivative of cinnamic acid, is derived from Danshen and exhibits anticancer properties by disrupting cancer cell activities. However, its role in pancreatic cancer, the "king of cancer", was unknown. In this study, ...
RETRACTION: Pentoxifylline Prevents Epileptic Seizure via Modulating HMGB1/RAGE/TLR4 Signalling Pathway and Improves Memory in Pentylenetetrazol Kindling Rats [0.03%]
撤回：烟酸注射液与维生素C联合使用改善血管性痴呆模型大鼠学习记忆能力及相关标志物的表达
G. A. Badawi, M. M. Shokr, H. F. Zaki and A. F. Mohamed, "Pentoxifylline Prevents Epileptic Seizure via Modulating HMGB1/RAGE/TLR4 Signalling Pathway and Improves Memory in Pentylenetetrazol Kindling Rats," Clinical and Experimental Pharmac...
Retraction of Publication
Clinical and experimental pharmacology & physiology. 2025 Mar;52(3):e70023. DOI:10.1111/1440-1681.70023 2025
Molecular Mechanism of Ginsenoside Rg3 Alleviation in Osteoporosis via Modulation of KPNA2 and the NF-κB Signalling Pathway [0.03%]
人参皂苷Rg3通过调节KPNA2和NF-κB信号通路缓解骨质疏松的分子机制
Xiaonan Zhang,Fenglan Huang,Jinzhu Liu et al.
Xiaonan Zhang et al.
Osteoporosis is mainly caused by an imbalance in osteoclast and osteoblast regulation, resulting in an imbalance in bone homeostasis. Ginsenoside Rg3 (Rg3) has been reported to have a therapeutic effect on alleviating osteoporosis. Nonethel...
Diclofenac Enhances the Response of BRAF Inhibitor to Melanoma Through ROS/p38/p53 Signaling [0.03%]
通过ROS/p38/p53信号传导，双氯芬酸增强BRAF抑制剂对黑色素瘤的治疗效果
Haihong Qin,Zheng Li,Jinfeng Wu et al.
Haihong Qin et al.
BRAF inhibitors (BRAFi) represent a cornerstone in melanoma therapy due to their high efficacy. However, the emergence of resistance causes a significant challenge to their clinical utility. This study aims to investigate the potential of d...
Predictive Effect of FT3 Within the Euthyroid Range on LDL-C in Patients With Type 2 Diabetes: A Cross-Sectional Analysis of Inpatients in China [0.03%]
中国住院患者的横断面分析：FT3在正常甲状腺功能范围内的预测作用对2型糖尿病患者LDL-C的影响
Yujue Wang,Chi Zhang,Shangshuang Zhao et al.
Yujue Wang et al.
Evidence regarding the relationship between free triiodothyronine (FT3) and low-density lipoprotein cholesterol (LDL-C) remains limited. This study aimed to evaluate the association between FT3 and LDL-C levels in patients with type 2 diabe...
Restoring Autophagy by Exercise Ameliorates Insulin Resistance Partly via Calcineurin-Driven TFEB Nuclear Translocation [0.03%]
运动通过钙调神经磷酸酶驱动的TFEB核转位恢复自噬从而改善胰岛素抵抗
Ping Wang,Jiaxin Li,Chun Guang Li et al.
Ping Wang et al.
Exercise activates autophagy and lysosome system in skeletal muscle, which are known to play an important role in metabolic adaptation. However, the mechanism of exercise-activated autophagy and lysosome system in obese insulin resistance r...
Sirt6, Deubiquitinated and Stabilised by USP9X, Takes Essential Actions on the Pathogenesis of Experimental Autoimmune Myasthenia Gravis by Regulating CD4+ T Cells [0.03%]
去泛素化并由USP9X稳定化的Sirt6通过调节CD4+T细胞在实验性自身免疫性重症肌无力发病机制中起重要作用
Chen Xie,Hong-Lian Zhang,Jun Yuan et al.
Chen Xie et al.
Myasthenia gravis (MG) presents with symptoms that significantly affect patients' daily lives. Long-term MG therapies may lead to substantial side effects, predominantly due to prolonged immune suppression. Sirt6, which plays a vital role i...