Combination of Tanshinone IIA and Matrine Alleviates Lipopolysaccharide-Induced Acute Lung Injury by Supressing Ferroptosis via Nrf2/HO-1 Pathway Activation [0.03%]
基于Nrf2/HO-1信号通路抑制铁死亡的藏红花酸钠和小檗胺联合抗脂多糖诱导急性肺损伤作用及机制研究
Huanqing Xiong,Yujuan Li,Jiaying Gao et al.
Huanqing Xiong et al.
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening conditions that involve severe lung inflammation leading to respiratory failure. Tanshinone IIA (TIIA) and Matrine (MAT), two herbal medicinal compo...
The Health Education During Root Canal Therapy Reduces the Use of Antibiotics [0.03%]
根管治疗期间的健康教育可减少抗生素的使用
Ting Yi,Fan Gu,Shengbo Liu et al.
Ting Yi et al.
Although antibiotics can effectively control infectious diseases, overuse of antibiotics can cause problems such as drug resistance. Pulpitis and apical periodontitis are among the most common infectious diseases in humans. To alleviate the...
Indole-3-Propionic Acid Improves Vascular Function in High-Fat Diet-Induced Obese Mice via eNOS [0.03%]
吲哚-3-丙酸通过eNOS改善高脂饮食诱导的肥胖小鼠的血管功能
Shaying Yang,Zhiwei Wang,Xin Wen
Shaying Yang
Background: The gut microbiota-derived metabolite indole-3-propionic acid (IPA) has been implicated in vascular homeostasis; however, its role in mesenteric vascular function and blood pressure regulation under obese cond...
Kisspeptin-10 Preserves the Blood-Brain Barrier's Integrity Post-Stroke by Augmenting Claudin-10 Expression [0.03%]
亲吻肽-10通过增加闭锁蛋白-10的表达来维持中风后血脑屏障的完整性
Liming Li,Yunlong Guo,Kaijie Zhao
Liming Li
The integrity of the Blood-Brain Barrier (BBB) is crucial in the pathophysiological progression of acute ischemic stroke (AIS). However, the potential of Kisspeptin-10 (Kp-10), with its antioxidant and anti-inflammatory properties, has not ...
Activation of GPR39 Ameliorates Placental Dysfunction by Inhibiting Activation of NLRP1 Inflammasome in Gestational Diabetes Mellitus [0.03%]
GPR39激活通过抑制NLRP1炎性小体活化改善妊娠糖尿病胎盘功能障碍
Xiaohua Zhou,Hong Sun
Xiaohua Zhou
Gestational diabetes mellitus (GDM) is a metabolic condition defined by glucose intolerance during pregnancy, which frequently results in placental malfunction, oxidative stress, and chronic inflammation, all of which are linked to the acti...
Overexpression of miR-718 in Keratinocytes Affects the Psoriatic Inflammation via Targeting STAT1: In Vitro and In Vivo Evidence [0.03%]
miR-718过表达通过靶向STAT1影响银屑病炎症：体内外证据
Himani Rani,Neeru Saini
Himani Rani
Psoriasis is a complex inflammatory autoimmune skin illness that causes epidermal keratinocyte hyperproliferation and dedifferentiation. In a previous study we did in the lab, we found that treating human keratinocytes (HaCaT) with PUVA inc...
Kaempferol Ameliorates Sepsis-Acute Lung Injury by Promoting Succinylation of SRPK1 [0.03%]
芸香素通过促进SRPK1琥珀酰化改善脓毒症急性肺损伤
Yuan Zhang,Huilin Liu,Yan Jin
Yuan Zhang
Sepsis is the leading cause of acute lung injury (ALI), and kaempferol has a protective effect against ALI. However, the underlying mechanisms have not been fully elucidated. This study aimed to investigate the role of kaempferol in sepsis-...
Rufinamide Mitigates Seizures and Behavioural Deficits via BDNF/TrkB Modulation and Oxidative Stress Reduction in Pentylenetetrazole-Kindled Mice [0.03%]
鲁非尼胺通过神经营养因子BDNF/TrkB调节和抗氧化作用减轻戊四唑点燃小鼠的癫痫发作及行为异常
Saima Abbas,Abida Parveen,Waseem Ashraf et al.
Saima Abbas et al.
Background: Rufinamide (RUF) is a 3rd generation antiseizure medication (ASM) with a triazole ring that blocks voltage-gated sodium channels (VGSCs) and is most commonly used to treat Lennox-Gastaut syndrome. Thus, the pr...
Effects of Genetic Polymorphisms of CYP450 Enzymes on Blood Hydroxychloroquine Levels and Clinical Response Among Patients With Cutaneous Lupus Erythematosus [0.03%]
狼疮患者CYP450酶基因多态性对羟氯喹血药浓度及临床疗效的影响
Jatta Njundu,Qi E Chia,Stanslas Johnson et al.
Jatta Njundu et al.
Whole blood hydroxychloroquine (WBHCQ) levels were found to correlate with cutaneous lupus (CLE) disease severity. Studies have shown HCQ to be highly variable in blood concentrations and clinical response among patients; however, the exact...