Bosutinib Inhibits USP9X to Suppress the Proliferation, Migration, Angiogenesis and Glycolysis of Hepatocellular Carcinoma Cells by Deubiquitinating PLK1 [0.03%]
博苏替尼通过去泛素化PLK1抑制USP9X来抑制肝细胞癌的增殖、迁移、血管生成和糖酵解
Cuiping Lu,Tiantian Cao,Zirong Li et al.
Cuiping Lu et al.
Background: Hepatocellular Carcinoma (HCC) is a matter of great global public health importance; however, its current therapeutic effectiveness is deemed inadequate, and the range of therapeutic targets is limited. This s...
Electroacupuncture Alleviates Focal Cerebral Ischemia-Reperfusion Injury and Is Associated With Modulation of Autophagy-Ferroptosis Involving the STAT3/HIF-1α Signalling Pathway [0.03%]
电针通过调节STAT3/HIF-1α信号通路介导的自噬-铁死亡平衡来缓解局灶性脑缺血再灌注损伤
Sisi Li,Liping Gao,Linjie Mu et al.
Sisi Li et al.
Focal cerebral ischemia-reperfusion injury remains a major clinical challenge in stroke management. Electroacupuncture (EA) may confer neuroprotection by modulating key cellular processes; however, its precise role in regulating autophagy-f...
Relationship Between Long-Term Exposure to Airborne Particulate Matter and the Intrinsic Capacity of Middle-Aged and Older Adults in China: A Retrospective Cohort Study Based on CHARLS [0.03%]
基于CHARLS的我国中老年人长期暴露于大气颗粒物与机体固有活性关系的回顾性队列研究
Jiatong Li,Yuxin Wu,Yaru Zhou et al.
Jiatong Li et al.
Background: Intrinsic capacity (IC), proposed by the World Health Organization, reflects the composite of an individual's physical and mental capacities and is considered a key indicator of healthy aging. Although air pol...
Dapagliflozin Improves Mitochondrial Function to Reduce the Risk of Atrial Fibrillation in a High-Glucose Environment by Activating the AMPK/PGC-1α/SIRT3 Signalling Pathway [0.03%]
达格列净通过激活AMPK/PGC-1α/SIRT3信号通路改善高糖环境下的线粒体功能以降低房颤风险
Xingxing Li,Guibing He,Fen Zhang et al.
Xingxing Li et al.
Background: Type 2 Diabetes Mellitus (T2DM) and AF (Atrial Fibrillation) frequently coexist, amplifying cardiovascular risks via shared mitochondrial dysfunction involving metabolic dysregulation, oxidative stress, and in...
Hypertension-Mediated Organ Damage: Pathophysiological Mechanisms, Clinical Consequences, and Implications for Early Risk Stratification [0.03%]
高血压介导的器官损害：病理生理机制、临床后果及早期风险分层的意义
Ali Hussein Choker
Ali Hussein Choker
Hypertension-mediated organ damage (HMOD) represents a critical and dynamic stage on the cardiovascular continuum, serving as the primary mechanistic link between sustained arterial pressure elevation and major adverse cardiovascular and re...
Saikosaponin D Alleviates Atherosclerosis by Regulating Autophagy and Senescence of VSMCs via Inhibiting EPHB2 [0.03%]
远志皂苷D通过抑制EPHB2调节血管平滑肌细胞自噬和衰老从而缓解动脉粥样硬化
Meihua Yan,Tian Tang,Yanxiu Wang et al.
Meihua Yan et al.
Background: Atherosclerosis (AS) is a major cause of cardiovascular diseases, with OX-LDL-induced VSMC dysfunction being a critical pathogenic driver of AS development. Saikosaponin D (SSD), a bioactive compound, shows th...
Noninvasively Evaluating the Cerebral Blood Flow Changes After Surgery in Adult Moyamoya Patients Using 3D Pulsed Arterial Spin Labelling MRI [0.03%]
利用3D脉冲动脉自旋标记MRI技术无创性评价成人 moyamoya 病患者术后脑血流变化
Zhenfang Zhu,Biaoling Chen,Wei Zhao et al.
Zhenfang Zhu et al.
Purpose: To explore the feasibility of phase contrast (PC) MRI and three-dimensional pulsed arterial spin labelling (3D PASL)-MRI in assessing cerebrovascular blood flow changes after surgical revascularization in patient...
Targeting S100A8/A9 Ameliorates Heart Failure with Preserved Ejection Fraction by Modulating TLR4/NF-κB-Mediated Inflammation [0.03%]
靶向S100A8/A9蛋白可调节TLR4/NF-κB介导的炎症以改善射血分数保留的心力衰竭
Yansong Li,Qi Han,Xianling Liu et al.
Yansong Li et al.
Background: Heart failure with preserved ejection fraction (HFpEF) has emerged as one of the most challenging public health issues worldwide, with few effective preventive and therapeutic options available. S100A8/A9 is a...
Cynomorium songaricum Rupr. Polysaccharide (CSP) Attenuates Diabetic Nephropathy by Activating AMPK/SIRT1 Signalling [0.03%]
Cynomorium songaricum Rupr.多糖通过激活AMPK/SIRT1信号通路对抗糖尿病肾病
Cheng Wan,Bingxin Cheng,Jinlei Li et al.
Cheng Wan et al.
Objective: Diabetic nephropathy (DN) represents a significant complication of diabetes and serves as a primary trigger for end-stage renal disease. The study aimed to investigate the renal protective influence of Cynomori...
HSPB7 Deficiency Drives Aortic Aneurysm Progression in Marfan Syndrome Through Vascular Smooth Muscle Cell Phenotypic Switching [0.03%]
热休克蛋白β家族成员7通过血管平滑肌细胞表型转换在马方综合征动脉瘤发生发展中的作用研究
Zining An,Tao Yan,Yang Ming et al.
Zining An et al.
Marfan syndrome (Mfs) arises from mutations in FBN1, predisposing individuals to thoracic aortic aneurysm (TAA) through abnormal smooth muscle cell behaviour. The role of HSPB7 in Mfs-related TAA remains poorly understood. By integrating mu...