Blood-Brain Barrier-Permeable siRNA Nanodrugs With Dual-Gene Knockdown for Alzheimer's Disease Therapy [0.03%]
用于阿尔茨海默病治疗的可穿越血脑屏障的具有双重基因敲除功能的siRNA纳米药物
Feng Su,Shengnan Lu,Yaoyao Zhang et al.
Feng Su et al.
Background: The presence of a blood-brain barrier (BBB) prevents the delivery of most drugs to the brain. This characteristic limitation poses a major challenge to effective pharmacological treatment for numerous neurodeg...
Acepromazine Reduces Airway Contraction in a Murine Model of Asthma [0.03%]
ACEpromazine减少哮喘小鼠模型气道收缩作用的研究
Alembert Lino-Alvarado,Maria Aparecida de Oliveira,Carmen Silvia Moreno Serra et al.
Alembert Lino-Alvarado et al.
Acepromazine (ACP) is one of the most used sedatives in veterinary medicine, and its cardiovascular effects are well documented. In contrast, its effects on the respiratory system remain less well understood, particularly in the context of ...
Sympathetic Nerve Activation Drives Cardiac Fibrosis and Arrhythmia in Lean Metabolic Dysfunction-Associated Steatohepatitis Mice Concurrently Exposed to Ethanol and a High-Fat/High-Cholesterol Diet [0.03%]
交感神经激活驱动乙醇和高脂/高胆固醇饮食并发暴露的小鼠代谢功能障碍相关脂肪肝病中心脏纤维化和心律失常的发展
Jinyao Liu,Seiko Yamano
Jinyao Liu
Background: Lean metabolic dysfunction-associated steatohepatitis (MASH) is increasingly recognised in non-obese individuals and is associated with cardiovascular complications, including arrhythmias. Although sympathetic...
Gemfibrozil Prevents Myocardial Ischemia-Reperfusion Injury in Mice Through AMPK Activation [0.03%]
吉非罗齐通过活化AMP激活的蛋白激酶防止小鼠心肌缺血-再灌注损伤
Yilong Jiang,Weijing Wang,Qi Li et al.
Yilong Jiang et al.
Myocardial ischemia-reperfusion injury (MIRI) causes severe clinical complications in patients. Although gemfibrozil (GEM) has been extensively studied in metabolic diseases, its effects on MIRI remain unknown. In this study, we investigate...
The TNF-α-FABP4-Dhhc7 Axis Mediates Olanzapine-Induced Insulin Resistance in Rats and Humans [0.03%]
TNF-α-FABP4-DHHC7轴介导奥氮平致胰岛素抵抗的机制（动物和临床研究）
Jing Wang,Peiru Chen,Chuyue Tu et al.
Jing Wang et al.
A rapid increase in the incidence of insulin resistance (IR) induced by long-term olanzapine treatment has been observed; however, there are no more efficient ways to prevent IR. Our study aimed to demonstrate the mechanism underlying olanz...
Acupuncture Alleviates Cerebral Ischemia-Reperfusion Injury by Inhibiting Ferroptosis Through the IRP2/IRE Pathway [0.03%]
针刺通过IRP2/IRE信号通路抑制铁死亡从而缓解脑缺血再灌注损伤
Jia Yuan,Litong Chen,Qianjun Li et al.
Jia Yuan et al.
Acupuncture (AC) has been demonstrated to improve outcomes in ischemic stroke. However, its precise mechanism of action remains incompletely understood. This study investigated the effects of AC in a rat model of cerebral ischemia-reperfusi...
Kruppel-Like Factor 5 Modulates the Nuclear Factor Erythroid-2-Related Factor 2/Heme Oxygenase 1 Signalling Pathway to Regulate Vascular Smooth Muscle Cell Ferroptosis in Abdominal Aortic Aneurysm [0.03%]
Krüppel样因子5通过调节核因子E2相关因子2/血红素氧合酶1信号通路调控腹主动脉瘤血管平滑肌细胞铁死亡
Guangwei Yang,Cong Yu,Chao Weng
Guangwei Yang
Objective: Abdominal aortic aneurysm (AAA) refers to a disease where the abdominal aorta progressively dilates to 3.0 cm or more, making it prone to rupture. The etiologic and pathophysiological mechanisms underlying the ...
Ddx17 Mitigates Sepsis-Induced Cardiomyopathy by Regulating Mitochondrial Dynamics in Cardiomyocytes [0.03%]
Ddx17通过调节心肌细胞线粒体动力学来缓解脓毒症诱导的心肌病
Ya-Ting Jiang,Li-Ran Su,Fang-Jing Ni et al.
Ya-Ting Jiang et al.
Sepsis-induced cardiomyopathy (SICM) is a severe complication of sepsis, in which mitochondrial dysfunction contributes to poor outcomes. DEAD-box helicase 17 (Ddx17), a member of the DEAD-box RNA helicase family, is known to regulate mitoc...
Effect and Mechanism of Shenqi Lixin Formula on Angiogenesis and Glucose Metabolism in Rats With Heart Failure After Myocardial Infarction [0.03%]
参芪苈香汤对心肌梗死后心力衰竭大鼠血管新生及糖代谢的影响和机制研究
Jiaqi Liu,Qili Zhao,Hezhan Wang et al.
Jiaqi Liu et al.
Post-myocardial infarction (MI) patients remain at high risk for developing heart failure (HF). This study investigated the therapeutic effects and mechanistic basis of Shenqi Lixin Formula (SQLXF) on angiogenesis and glucose metabolism in ...