Plasma IL4 Levels Linked to Pulmonary Hypertension Severity and Outcome [0.03%]
血清中IL-4水平与肺动脉高压严重程度及预后有关联
Yun Li,Yi Liu,Zhanping Liang et al.
Yun Li et al.
Background: The anti-inflammatory cytokine interleukin-4 (IL4) has been recognised as a protective factor in various cardiovascular events, yet its prognostic value in patients with pulmonary hypertension (PH) remains unc...
Electroacupuncture Attenuates Cerebral Ischemia-Reperfusion Injury by Inhibiting Ferroptosis via the p53/SLC7A11 Pathway [0.03%]
电针通过p53/SLC7A11通路抑制铁死亡来缓解脑缺血再灌注损伤
Ziwen Hou,Yaoyao Liu,Qi Wang et al.
Ziwen Hou et al.
Acupuncture has demonstrated efficacy in treating post-stroke complications. Electroacupuncture (EA) ameliorates neurological outcomes in cerebral ischemia models, yet its mechanisms remain unclear. This study investigated EA's role in redu...
Global, Regional, and National Temporal Trend and Patterns of Change in the Burden of Asthma From 1990 to 2021: An Analysis of the Global Burden of Disease Study 2021 [0.03%]
1990年至2021年全球、区域和国家哮喘负担的变化趋势与模式：基于2021年全球疾病负担研究的分析
Shuyi Mu,Yu Wang,Jie Cui et al.
Shuyi Mu et al.
Background: Asthma presents a significant challenge to the global healthcare systems and imposes a heavy socioeconomic burden. Previous studies had geographical limitations and lacked comprehensive global analysis. The st...
Inhibition of Hsp90 Alleviates Necroptosis and Inflammation in Lung Epithelial Cells During Pulmonary Ischemia-Reperfusion Injury [0.03%]
Hsp90抑制通过减轻肺缺血再灌注损伤中的坏死性凋亡和炎症保护肺上皮细胞
Xiaofang Xu,Zhiling Lou,Jinsheng Li et al.
Xiaofang Xu et al.
Lung ischemia-reperfusion injury (LIRI) is a critical pathological process associated with various clinical conditions, characterised by excessive inflammatory responses and cell death, which can lead to severe respiratory dysfunction and e...
Pancreatitis Independently Induced by Hypertriglyceridaemia Outlines the Immune Profiles of HTGP in Clinic [0.03%]
高甘油三酯血症独立诱发的胰腺炎明确了HTGP临床免疫谱型
Jianxing Liu,Caixia Liang,Wenjing Yan et al.
Jianxing Liu et al.
Hypertriglyceridaemia (HTG) is a common and well-established aetiology of acute pancreatitis (AP). Although the underlying pathophysiology of hypertriglyceridaemic pancreatitis (HTGP) is complex, some animal models of HTAP have been success...
Norisoboldine Alleviates Isoproterenol-Induced Myocardial Ischemic Injury via the TLR4-MyD88-Dependent NF-κB Activation Pathway and Modulation of L-Type Calcium Channels [0.03%]
诺里索伯尔丁通过TLR4-MyD88依赖的NF-κB激活途径和L型钙通道调节减轻异丙肾上腺素诱导的心肌缺血损伤
Xin Zhang,Xinliu Wang,Yuanyuan Wang et al.
Xin Zhang et al.
Norisoboldine (NIB) displays beneficial effects on cardiovascular diseases, although its protective role and underlying mechanisms in myocardial ischemia (MI) injury remain elusive. The aim of this study is to explore the potential cardiopr...
Flavokawain A Ruthenium-p-Cymene Complex-Induced Apoptosis by the Modulation of PI3K/β-Catenin/HER2/PARP Signalling in Lung Cancer [0.03%]
黄姜辣素A通过调节肺癌中的PI3K / β - 连环蛋白/ HER2 / PARP信号传导诱导的钌-p-伞花烃复合物诱导的凋亡
Sakuntala Gayen,Souvik Roy,Diana Laishram et al.
Sakuntala Gayen et al.
Lung cancer is most terrible cause of cancer-related death throughout the world. This study focused on the synthesis and characterisation of novel flavokawain A ruthenium-p-cymene complex and to investigate the chemotherapeutic activity aga...
Prophylactic Effects of Rhamnetin Flavonoid on Indomethacin-Induced Gastric Ulceration by Modulating HSP 70/Bax, SOD/MDA and TNF-α/IL-10 [0.03%]
黄酮槲皮素通过调节热休克蛋白70/Bax，SOD/MDA和TNF-α/IL-10对吲哚美辛诱导的胃溃疡的预防作用
Mohammed T Mohammed,Talal Salem Al-Qaisi,Ahmed A J Jabbar et al.
Mohammed T Mohammed et al.
Rhamnetin is a naturally occurring flavonoid compound found in many wild plant species and indigenous fruits. Despite its numerous biological potentials, such as anti-inflammatory, antioxidant and antimicrobial effects, there is a lack of l...
Development and Validation of a Comprehensive Risk Prediction Model for Polypoid Lesions of the Gallbladder [0.03%]
胆囊息肉样病变综合风险预测模型的建立和验证
Chunxu Dou,Yanzhi Han,Lu Lin et al.
Chunxu Dou et al.
Polypoid lesions of the gallbladder (PLG) represent localised protrusions of the gallbladder wall, which can be either benign or malignant. Although malignant PLG is relatively rare, its prognosis is adverse. Cholecystectomy is the most eff...
LeuRS-Targeting Prodrug, MRX-5, Expresses Anti-Mycobacterium abscessus Activity [0.03%]
靶向LeuRS的前药MRX-5对麻风分枝杆菌具有抗菌活性
Anqi Li,Siyuan He,Yaping Jia et al.
Anqi Li et al.
Mycobacterium abscessus is a multi-drug resistant pathogen presenting significant treatment challenges. This study evaluated MRX-5, an oral prodrug of the leucyl-tRNA synthetase inhibitor MRX-6038, for its efficacy against M. abscessus both...