Linarin Relieves Apoptosis, Inflammation and Oxidative Stress in LPS-Induced Acute Kidney Injury by Modulating COX2 [0.03%]
茋类成分异荭草素通过调节COX2缓解脂多糖诱导的急性肾损伤中细胞焦亡、炎症及氧化应激反应
Jia Zhang,Wenqi Wang,Yafen Liu et al.
Jia Zhang et al.
Background: Acute kidney injury (AKI) is a common clinical disease with a rapid decline of renal function. Linarin (LIN) is a flavonoid compound with wide application in different diseases. However, the role and relevant ...
A Novel Inhibitor of Methyltransferase SMYD2, AZ505 Protects Against Peritoneal Fibrosis in Mice [0.03%]
一种SMYD2甲基转移酶抑制剂AZ505可通过抑制小鼠腹膜纤维化来保护肾脏
Taijing Xu,Binbin Cui,Feng Liu et al.
Taijing Xu et al.
AZ505, a highly selective inhibitor of SMYD2, exhibits an antifibrotic effect in renal fibrosis. Its effect on peritoneal fibrosis remains unexplored. In this study, we investigated its effects on the development of peritoneal fibrosis indu...
MRGPRX2-Mediated Mast Cell Degranulation by Monomethyl Methacrylate: Unveiling a Pathway in Bone Cement Implantation Syndrome [0.03%]
单甲基丙烯酸酯介导的MRGPRX2+肥大细胞脱颗粒在骨水泥沉植综合征中的作用机制研究
Yasuyuki Suzuki,Liu Shuang,Erika Takemasa et al.
Yasuyuki Suzuki et al.
Bone cement implantation syndrome is a critical complication of orthopaedic surgery, characterised by hypotension and hypoxemia. This syndrome is hypothesised to result from obstruction caused by fat droplets and the biochemical release of ...
Sepsis Important Genes Identification Through Biologically Informed Deep Learning and Transcriptomic Analysis [0.03%]
基于生物信息的深度学习和转录组学分析的脓毒症重要基因识别
Ruichen Li,Qiushi Wang,Ru Gao et al.
Ruichen Li et al.
Sepsis is a life-threatening disease caused by the dysregulation of the immune response. It is important to identify influential genes modulating the immune response in sepsis. In this study, we used P-NET, a biologically informed explainab...
Büyükcavlak Mustafa
Büyükcavlak Mustafa
The study by An et al. provides valuable insights into rocuronium pharmacodynamics in patients with high body fat percentages (PBF). However, the lack of normalisation for acceleromyographic train-of-four (TOF) ratios raises concerns about ...
Reliability of Matrix-Assisted Laser Desorption-Ionisation Time-of-Flight Mass Spectrometry as a Method for Drug-Resistant Tuberculosis Gene Identification [0.03%]
基质辅助激光解析离子化飞行时间质量光谱法鉴定耐药结核分枝杆菌基因可靠性的研究
Kaishun Zhao,Wei Wei,Lijia Yang et al.
Kaishun Zhao et al.
Instances of drug-resistant tuberculosis (TB), particularly multidrug- and extensive drug-resistant TB, are escalating worldwide; therefore, there is an urgent need to explore suitable treatment strategies. This study assessed the precision...
Alpha-Linolenic Acid for Mitigating Neuroinflammation and Dopaminergic Neuronal Loss in Parkinson's Disease: Insights From In Vivo and In Silico Studies [0.03%]
亚麻仁油酸减轻帕金森病神经炎症和多巴胺能神经元损失的潜力：来自体内和体外研究的启示
Mahnoor,Sarwat Jahan,Laila Elahi et al.
Mahnoor et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by dopaminergic neuronal loss and chronic neuroinflammation, leading to significant motor and non-motor deficits. This study explores the therapeutic potenti...
Sex Steroid Control of Serotonergic System: Clinical Implications for Psychiatric Disorders and Addiction Treatment [0.03%]
性类固醇控制血清素系统：对精神疾病和药物成瘾治疗的临床意义
Lien-Chung Wei,Hsien-Jane Chiu
Lien-Chung Wei
The seminal work by Fink et al. on sex steroid regulation of mood, cognition, and memory has profound implications for understanding sex differences in psychiatric disorders and addiction treatment. Their findings that estradiol upregulates...
The Rough Morphotype of Mycobacterium abscessus Enhances Its Virulence Through ROS/p65/NLRP3/GSDMD-Mediated Macrophage Pyroptosis [0.03%]
粗糙型麻风分枝杆菌通过ROS/p65/NLRP3/GSDMD介导的巨噬细胞焦亡增强其毒力
Jingren Li,Juan Li,Anqi Li et al.
Jingren Li et al.
The rough morphotype of Mycobacterium abscessus exhibits significantly higher virulence compared to the smooth morphotype, yet the underlying molecular mechanisms remain incompletely understood. Pyroptosis in macrophages plays a pivotal rol...
Endothelin System Blockade Extenuates Sepsis-Induced Acute Heart and Kidney Injuries via Modulating ET-1/Klotho/p38-MAPK [0.03%]
内皮素系统阻断通过调节ET-1/Klotho/p38-MAPK缓解脓毒症诱导的心肾急性损伤
Alaa Al-Kadi,Aliaa F Anter,Remon Roshdy Rofaeil et al.
Alaa Al-Kadi et al.
Sepsis-induced organ failure is a major health problem, characterised by massive inflammatory and oxidative stress responses. Endothelin-1 (ET-1) is one of the peptides expressed during septicemia with proapoptotic, proinflammatory, and oxi...