Exploring Phytochemical Adjuvant Therapy in Melanoma Treatment: The Effects of MAZ-51 and Zingerone on Melanoma Cell Proliferation [0.03%]
探讨植物化学辅助治疗在黑色素瘤治疗中的作用：MAZ-51和姜辣素对黑色素瘤细胞增殖的影响
Kganya Letsoalo,Charlise Basson,Trevor Nyakudya et al.
Kganya Letsoalo et al.
Current melanoma treatment results in adverse effects, prompting the use of phytochemicals as adjuvant therapy to reduce the reliance on synthetic drugs and combat drug resistance. This study investigated the in vitro effect of (3-(4-Dimeth...
Anatomical Classification and Clinical Significance of Right Middle Lobe Vein Confluence Variations in Right Upper Lobectomy: A Three-Dimensional Reconstruction Study [0.03%]
右肺上叶切除术中右中间支静脉汇入变异的解剖分型及临床意义：基于三维重建的研究
Tian Hao,Lei Xu,Si-Ming Jiang et al.
Tian Hao et al.
Background: Anatomical variations of the right middle lobe (RML) veins pose significant risks during video-assisted thoracoscopic right upper lobectomy (RUL), where unrecognised veins traversing the horizontal fissure may...
Sinomenine Suppresses Hepatocellular Carcinoma Cell Migration and Invasion by Inhibiting O-GlcNAcylation of SP1 [0.03%]
长春西汀通过抑制SP1的O-连接的N-乙酰氨基葡萄糖修饰抑制肝癌细胞迁移和侵袭
Lanqin Liu,Junwen Peng,Haixia Chen et al.
Lanqin Liu et al.
Sinomenine (SIN) is an extract obtained from the plant Sinomenium acutum, which has been reported in hepatocellular carcinoma (HCC) and many other different types of human cancers as an anti-tumour agent. However, the molecular mechanism mo...
M2 Macrophages-Derived Exosomes Inhibited Podocyte Pyroptosis via lncRNA AFAP1-AS1/EZH2 Axis [0.03%]
巨噬细胞源外泌体通过lncRNA AFAP1-AS1/EHZ2轴抑制足细胞焦亡
Qing Zhan,Huiyun Liu,Minyang Zhao et al.
Qing Zhan et al.
Macrophage infiltration was closely associated with inflammatory injury of podocytes in diabetic nephropathy (DN), while how macrophages affected podocytes remained not entirely clear. Here, we not only investigated the relationship between...
Potential Kidney Risks Associated With Clinical Doses of Omeprazole: In Vivo and In Vitro Studies [0.03%]
临床剂量奥美拉唑潜在的肾脏风险：体内和体外研究
Zibo Xiong,Zhiwei Lai,Sanmu Li et al.
Zibo Xiong et al.
Omeprazole is a widely used proton pump inhibitor and anti-Helicobacter pylori drug; however, its nephrotoxicity has been controversial. This study aimed to explore the effects and mechanisms of omeprazole on the kidney. In HK2, HPC, NRK an...
Decrease in Mitochondrial Oxidative Respiratory Function in Liver of Cricetulus barabensis Under Long and Short Photoperiods: The Role of Mitochondrial Fission and Apoptosis [0.03%]
长期和短期光周期下仓鼠肝线粒体氧化呼吸功能下降：线粒体分裂及凋亡的影响
Jin-Hui Xu,Lu-Fan Li,Yi-Man Liu et al.
Jin-Hui Xu et al.
The photoperiod is a crucial factor affecting the seasonal rhythms of mammals. Under the seasonal rhythms, the growth and development of the body are closely related to the oxidative respiratory function of mitochondria, but the influence o...
Frailty: An Important Determinant Influencing Glycaemic Control in Elderly Chinese Patients Diagnosed With Type 2 Diabetes [0.03%]
衰弱对老年中国人2型糖尿病患者血糖控制的影响作用不容忽视
Lei Cao,Shuang-Shuang Chen,Qing Xu et al.
Lei Cao et al.
Few studies have investigated blood glucose levels and complication management in elderly patients with type 2 diabetes (T2D) at community hospitals in China. The objective of this study was to investigate the factors influencing blood gluc...
GPR39 Activation Attenuates AngII-Induced Abdominal Aortic Aneurysm by Suppressing ETS-1 Mediated VEGF-A/VEGFR2 Signalling [0.03%]
GPR39活化通过抑制ETS-1介导的VEGF-A/VEGFR2信号通路削弱AngII诱导的腹主动脉瘤形成
Bin Liu,Yiming Xu,Yuanyuan Liu et al.
Bin Liu et al.
Abdominal aortic aneurysm (AAA), a vascular condition that endangers life, is typified by the progressive weakening and dilation of the aortic wall. In its pathogenic process, oxidative stress and angiogenesis assume crucial functions. This...
Synthesis, Characterization, Molecular Dynamic Simulation and Neuroprotective Effects of Synthetic Isoxazolone Derivatives in Ethanol-Induced Neurodegeneration [0.03%]
异噁唑酮衍生物的合成、表征及分子动力学模拟和其在酒精诱导神经退行性疾病中的保护作用研究
Maria Awan,Faisal Albaqami,Humaira Nadeem et al.
Maria Awan et al.
Alcoholism and alcohol misuse are major public health concerns, and chronic alcohol consumption negatively impacts memory and can lead to neurodegeneration and neuroinflammation. Neuroinflammation is a prevalent characteristic of all neurol...
Stachydrine Protects Against Cyclophosphamide-Induced Premature Ovarian Insufficiency in Wistar Rats by Inhibiting Oxidative Stress and Apoptosis via the Activation of the Nrf2/HO-1 Signalling Pathway [0.03%]
天仙子碱通过激活Nrf2/HO-1信号通路抑制氧化应激和凋亡防治Wistar大鼠环磷酰胺所致卵巢早衰
Cong Feng,Yue Jiang,Yuehui Zhang et al.
Cong Feng et al.
Excessive oxidative stress and apoptosis of ovarian granulosa cells lead to severe ovarian dysfunctions and even premature ovarian insufficiency (POI). Stachydrine (STA), the main active component of Leonurus japonicas, possesses antioxidan...