Prophylactic Effects of Rhamnetin Flavonoid on Indomethacin-Induced Gastric Ulceration by Modulating HSP 70/Bax, SOD/MDA and TNF-α/IL-10 [0.03%]
黄酮槲皮素通过调节热休克蛋白70/Bax，SOD/MDA和TNF-α/IL-10对吲哚美辛诱导的胃溃疡的预防作用
Mohammed T Mohammed,Talal Salem Al-Qaisi,Ahmed A J Jabbar et al.
Mohammed T Mohammed et al.
Rhamnetin is a naturally occurring flavonoid compound found in many wild plant species and indigenous fruits. Despite its numerous biological potentials, such as anti-inflammatory, antioxidant and antimicrobial effects, there is a lack of l...
Development and Validation of a Comprehensive Risk Prediction Model for Polypoid Lesions of the Gallbladder [0.03%]
胆囊息肉样病变综合风险预测模型的建立和验证
Chunxu Dou,Yanzhi Han,Lu Lin et al.
Chunxu Dou et al.
Polypoid lesions of the gallbladder (PLG) represent localised protrusions of the gallbladder wall, which can be either benign or malignant. Although malignant PLG is relatively rare, its prognosis is adverse. Cholecystectomy is the most eff...
LeuRS-Targeting Prodrug, MRX-5, Expresses Anti-Mycobacterium abscessus Activity [0.03%]
靶向LeuRS的前药MRX-5对麻风分枝杆菌具有抗菌活性
Anqi Li,Siyuan He,Yaping Jia et al.
Anqi Li et al.
Mycobacterium abscessus is a multi-drug resistant pathogen presenting significant treatment challenges. This study evaluated MRX-5, an oral prodrug of the leucyl-tRNA synthetase inhibitor MRX-6038, for its efficacy against M. abscessus both...
Corticosterone-Induced Myocardial Dysfunctions and the Cardioprotective Role of Tauroursodeoxycholic Acid: An Experimental Study in Mice [0.03%]
糖皮质激素致小鼠心功能障碍及熊去氧胆酸氨基化合物的心脏保护作用：实验研究
Houyuan Zhou,Xiaoying Chen,Yanlin Tao et al.
Houyuan Zhou et al.
Background: Major depressive disorder increases cardiovascular risk through stress-induced elevated cortisol levels. Tauroursodeoxycholic acid (TUDCA), a bile acid, has been reported to have anti-inflammatory, anti-depres...
NSUN3 Aggravates Sepsis-Associated Acute Kidney Injury by Stabilising TIFA mRNA Through m5C [0.03%]
NSUN3通过m5C稳定TIFA mRNA从而加剧脓毒症相关急性肾损伤
Chenran Zhang,Wenming Shen,Xuwen Zheng et al.
Chenran Zhang et al.
Background: Acute kidney injury (AKI) is a common complication of sepsis and also a risk factor for progression of chronic kidney disease. NOP2/Sun RNA methyltransferase 3 (NSUN3) is involved in the regulation of sepsis p...
PHD3-Mediated Inhibition of Retinal Neovascularization in Retinopathy of Prematurity [0.03%]
PHD3介导的早产儿视网膜病变新生血管抑制作用
Jiawei Yu,Haifeng Liu,Yue Xing et al.
Jiawei Yu et al.
Retinopathy of prematurity is characterised by abnormal retinal neovascularization in response to hypoxia stress. Prolyl 4-hydroxylase domain protein 3 (PHD3) is a well-known molecular oxygen sensor. However, the role that PHD3 plays in ret...
Isoferulic Acid Inhibits Proliferation and Migration of Pancreatic Cancer Cells, and Promotes the Apoptosis of Pancreatic Cancer Cells in a Mitochondria-Dependent Manner Through Inhibiting NF-κB Signalling Pathway [0.03%]
异茋酸通过抑制NF-κB信号途径以线粒体依赖的方式促进胰腺癌细胞凋亡及抑制增殖和迁移的作用研究
Suqin Sun,Rong Fan,Li Chang et al.
Suqin Sun et al.
Isoferulic acid (IA), a derivative of cinnamic acid, is derived from Danshen and exhibits anticancer properties by disrupting cancer cell activities. However, its role in pancreatic cancer, the "king of cancer", was unknown. In this study, ...
RETRACTION: Pentoxifylline Prevents Epileptic Seizure via Modulating HMGB1/RAGE/TLR4 Signalling Pathway and Improves Memory in Pentylenetetrazol Kindling Rats [0.03%]
撤回：烟酸注射液与维生素C联合使用改善血管性痴呆模型大鼠学习记忆能力及相关标志物的表达
G. A. Badawi, M. M. Shokr, H. F. Zaki and A. F. Mohamed, "Pentoxifylline Prevents Epileptic Seizure via Modulating HMGB1/RAGE/TLR4 Signalling Pathway and Improves Memory in Pentylenetetrazol Kindling Rats," Clinical and Experimental Pharmac...
Retraction of Publication
Clinical and experimental pharmacology & physiology. 2025 Mar;52(3):e70023. DOI:10.1111/1440-1681.70023 2025
Molecular Mechanism of Ginsenoside Rg3 Alleviation in Osteoporosis via Modulation of KPNA2 and the NF-κB Signalling Pathway [0.03%]
人参皂苷Rg3通过调节KPNA2和NF-κB信号通路缓解骨质疏松的分子机制
Xiaonan Zhang,Fenglan Huang,Jinzhu Liu et al.
Xiaonan Zhang et al.
Osteoporosis is mainly caused by an imbalance in osteoclast and osteoblast regulation, resulting in an imbalance in bone homeostasis. Ginsenoside Rg3 (Rg3) has been reported to have a therapeutic effect on alleviating osteoporosis. Nonethel...
Diclofenac Enhances the Response of BRAF Inhibitor to Melanoma Through ROS/p38/p53 Signaling [0.03%]
通过ROS/p38/p53信号传导，双氯芬酸增强BRAF抑制剂对黑色素瘤的治疗效果
Haihong Qin,Zheng Li,Jinfeng Wu et al.
Haihong Qin et al.
BRAF inhibitors (BRAFi) represent a cornerstone in melanoma therapy due to their high efficacy. However, the emergence of resistance causes a significant challenge to their clinical utility. This study aims to investigate the potential of d...