Kisspeptin-10 Preserves the Blood-Brain Barrier's Integrity Post-Stroke by Augmenting Claudin-10 Expression [0.03%]
亲吻肽-10通过增加闭锁蛋白-10的表达来维持中风后血脑屏障的完整性
Liming Li,Yunlong Guo,Kaijie Zhao
Liming Li
The integrity of the Blood-Brain Barrier (BBB) is crucial in the pathophysiological progression of acute ischemic stroke (AIS). However, the potential of Kisspeptin-10 (Kp-10), with its antioxidant and anti-inflammatory properties, has not ...
Activation of GPR39 Ameliorates Placental Dysfunction by Inhibiting Activation of NLRP1 Inflammasome in Gestational Diabetes Mellitus [0.03%]
GPR39激活通过抑制NLRP1炎性小体活化改善妊娠糖尿病胎盘功能障碍
Xiaohua Zhou,Hong Sun
Xiaohua Zhou
Gestational diabetes mellitus (GDM) is a metabolic condition defined by glucose intolerance during pregnancy, which frequently results in placental malfunction, oxidative stress, and chronic inflammation, all of which are linked to the acti...
Overexpression of miR-718 in Keratinocytes Affects the Psoriatic Inflammation via Targeting STAT1: In Vitro and In Vivo Evidence [0.03%]
miR-718过表达通过靶向STAT1影响银屑病炎症：体内外证据
Himani Rani,Neeru Saini
Himani Rani
Psoriasis is a complex inflammatory autoimmune skin illness that causes epidermal keratinocyte hyperproliferation and dedifferentiation. In a previous study we did in the lab, we found that treating human keratinocytes (HaCaT) with PUVA inc...
Kaempferol Ameliorates Sepsis-Acute Lung Injury by Promoting Succinylation of SRPK1 [0.03%]
芸香素通过促进SRPK1琥珀酰化改善脓毒症急性肺损伤
Yuan Zhang,Huilin Liu,Yan Jin
Yuan Zhang
Sepsis is the leading cause of acute lung injury (ALI), and kaempferol has a protective effect against ALI. However, the underlying mechanisms have not been fully elucidated. This study aimed to investigate the role of kaempferol in sepsis-...
Rufinamide Mitigates Seizures and Behavioural Deficits via BDNF/TrkB Modulation and Oxidative Stress Reduction in Pentylenetetrazole-Kindled Mice [0.03%]
鲁非尼胺通过神经营养因子BDNF/TrkB调节和抗氧化作用减轻戊四唑点燃小鼠的癫痫发作及行为异常
Saima Abbas,Abida Parveen,Waseem Ashraf et al.
Saima Abbas et al.
Background: Rufinamide (RUF) is a 3rd generation antiseizure medication (ASM) with a triazole ring that blocks voltage-gated sodium channels (VGSCs) and is most commonly used to treat Lennox-Gastaut syndrome. Thus, the pr...
Effects of Genetic Polymorphisms of CYP450 Enzymes on Blood Hydroxychloroquine Levels and Clinical Response Among Patients With Cutaneous Lupus Erythematosus [0.03%]
狼疮患者CYP450酶基因多态性对羟氯喹血药浓度及临床疗效的影响
Jatta Njundu,Qi E Chia,Stanslas Johnson et al.
Jatta Njundu et al.
Whole blood hydroxychloroquine (WBHCQ) levels were found to correlate with cutaneous lupus (CLE) disease severity. Studies have shown HCQ to be highly variable in blood concentrations and clinical response among patients; however, the exact...
Early and Stable Mouse Model of Amphotericin B-Induced Acute Kidney Injury: Application of Continuous Non-Invasive GFR Monitoring [0.03%]
早发且稳定的两性霉素B诱导急性肾损伤小鼠模型：连续无创监测GFR的应用
Lifeng Shen,Yuchen Song,Yu Xiao et al.
Lifeng Shen et al.
Background: Amphotericin B (AmB) remains a cornerstone in antifungal therapy, but its clinical use is limited by dose-dependent nephrotoxicity. Lipid-based formulations such as amphotericin B cholesterol sulfate complex d...
Glycyrrhizic Acid Ameliorates LPS-Induced WI-38 Cell Inflammation, Oxidative Stress, and Ferroptosis via Targeting METTL14 in Infantile Pneumonia [0.03%]
甘草酸通过靶向METTL14缓解婴幼儿肺炎LPS诱导的WI-38细胞炎症、氧化应激和铁死亡
Xiaofei Xie,Caiwen Wang,Yingying Sun et al.
Xiaofei Xie et al.
Background: Infantile pneumonia is a common and significant health concern in the world, with elevated morbidity and mortality rates among affected children. This research is designed to demonstrate the therapeutic action...
Chlorogenic Acid Improves Salicylic Acid-Induced Cochlear Injury by Reducing Oxidative Stress and Inflammatory Response Through TLR4/NF-κB Signalling Pathway [0.03%]
氯ogenic酸通过TLR4/NF-κB信号通路减轻氧化应激和炎症反应以改善水杨酸致耳毒性损伤
Yi Lin,Lili Li,Jianbin Cheng
Yi Lin
Background: Sodium salicylate (SS) causes hearing damage and tinnitus in humans and animals. Chlorogenic acid (CGA) has strong antioxidant and anti-apoptotic effects, but whether it can protect the cochlea is unknown. ...