Exploring the Protective Role and Regulation of Prdx6 in Cisplatin-Induced AKI [0.03%]
探究过氧化物酶体丙二醛异构酶6在顺铂诱导的急性肾损伤中的保护作用及调控机制
Xianzhe Li,Jinbo Yu,Shi Cheng et al.
Xianzhe Li et al.
Cisplatin (CDDP) is a widely used chemotherapeutic agent that induces nephrotoxicity by generating excessive reactive oxygen species (ROS), leading to oxidative stress, inflammation and apoptosis in renal proximal tubular cells. Peroxiredox...
The ELF1/IGF2BP2/FAM111B Cascade Drives Colorectal Cancer Progression and Ferroptosis Resistance [0.03%]
ELF1/IGF2BP2/FAM111B级联驱动结直肠癌进展和铁死亡抵抗
Dian Yin,Lili Cao,Mei Hua et al.
Dian Yin et al.
Epigenetic dysregulation plays a critical role in colorectal cancer (CRC) progression. Our study investigated the role of FAM111B in tumorigenic phenotypes and ferroptosis in CRC and the mechanisms by which epigenetic alterations influence ...
Long-Term Anticoagulation and Outcomes of Head and Neck Cancer: Analysis of the US Nationwide Inpatient Sample [0.03%]
长期抗凝与头颈部肿瘤结局：基于美国国家住院样本分析
Chun-Feng Wu,Hang Huong Ling,Yun-Cong Zheng et al.
Chun-Feng Wu et al.
Venous thromboembolism (VTE) is a complication of head and neck cancer (HNC). However, the effectiveness of routine anticoagulation as a preventive measure and its impact on patient outcomes is unclear. The purpose of this study was to eval...
Inflammatory Bowel Disease and Novel Cell Death: Bibliometric Analysis and Study Trend Projections Based on Burst Detection [0.03%]
基于突发检测的炎症性肠病和新型细胞死亡的计量学分析及研究趋势预测
Hui Ouyang,Jingling Su,Jiawen Lin et al.
Hui Ouyang et al.
Objective: Inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), is a chronic relapsing gastrointestinal inflammatory disorder, whose underlying mechanisms remain elusive. Novel ce...
Safety Evaluation of Nitroimidazole Antibiotics Based on the FAERS Database [0.03%]
基于FAERS数据库的硝基咪唑类抗菌药物安全性评价
Qian Wu,Fansheng Wu,Han Jiang et al.
Qian Wu et al.
Nitroimidazole antibiotics, including metronidazole, tinidazole, and ornidazole, are widely used to treat anaerobic infections and parasitic diseases. Although their efficacy is well established, comprehensive safety profiles-particularly c...
PDZK1 Regulates the Stability and Function of ADRB2 to Prevent Vascular Remodelling in Hypertension [0.03%]
PDZK1通过调节高血压血管重构关键介质ADRβ2受体的稳定性和功能防治血管重构
Haoran Zhang,Yan Meng,Dandan Li et al.
Haoran Zhang et al.
In this study, we found that PDZK1, a scaffold protein, interacts with the β₂-adrenergic receptor (ADRB2) through its PDZ domains, stabilising ADRB2 by inhibiting its ubiquitination and proteasomal degradation. This study explored the PDZ...
Mitochondrial Oxidative Stress and Cardiac Dysfunction in TERT Deficient Progeria Mice [0.03%]
TERT缺陷的早衰小鼠的心脏功能障碍与线粒体氧化应激的关系
Zandong Zhou,Yunpeng Zhang,Rui Zhao et al.
Zandong Zhou et al.
Background: Heart failure (HF) is a major cause of hospitalisation in the elderly. Its incidence increases with aging and the presence of risk factors such as hypertension and diabetes. Aging-related myocardial fibrosis, ...
Combination of Tanshinone IIA and Matrine Alleviates Lipopolysaccharide-Induced Acute Lung Injury by Supressing Ferroptosis via Nrf2/HO-1 Pathway Activation [0.03%]
基于Nrf2/HO-1信号通路抑制铁死亡的藏红花酸钠和小檗胺联合抗脂多糖诱导急性肺损伤作用及机制研究
Huanqing Xiong,Yujuan Li,Jiaying Gao et al.
Huanqing Xiong et al.
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening conditions that involve severe lung inflammation leading to respiratory failure. Tanshinone IIA (TIIA) and Matrine (MAT), two herbal medicinal compo...
The Health Education During Root Canal Therapy Reduces the Use of Antibiotics [0.03%]
根管治疗期间的健康教育可减少抗生素的使用
Ting Yi,Fan Gu,Shengbo Liu et al.
Ting Yi et al.
Although antibiotics can effectively control infectious diseases, overuse of antibiotics can cause problems such as drug resistance. Pulpitis and apical periodontitis are among the most common infectious diseases in humans. To alleviate the...
Indole-3-Propionic Acid Improves Vascular Function in High-Fat Diet-Induced Obese Mice via eNOS [0.03%]
吲哚-3-丙酸通过eNOS改善高脂饮食诱导的肥胖小鼠的血管功能
Shaying Yang,Zhiwei Wang,Xin Wen
Shaying Yang
Background: The gut microbiota-derived metabolite indole-3-propionic acid (IPA) has been implicated in vascular homeostasis; however, its role in mesenteric vascular function and blood pressure regulation under obese cond...