Tabersonine Alleviates Cerebral Ischemia/Reperfusion Injury Partly via Repressing the SLC6A2/NF-κB Signalling Pathway [0.03%]
TABERNANOLINE通过抑制SLC6A2/NF-κB信号通路减轻缺血再灌注诱导的脑损伤
Li Zhang,Liji Chen,Juhua Chen et al.
Li Zhang et al.
The study aimed to investigate the neuroprotective functions and the underlying regulatory mechanisms of Tabersonine in cerebral ischemia/reperfusion (I/R) injury. Oxygen-glucose deprivation/reoxygenation (OGD/R)-treated neural cells were u...
Cellular Pharmacology of Bupivacaine in Lung Fibroblasts: Role of Intracellular Calcium Signalling and Chelation [0.03%]
左布比卡因在肺纤维母细胞的药理作用：细胞内钙离子信号转导及螯合作用的影响
Wei-Zhe Liang,Gwo-Ching Sun
Wei-Zhe Liang
Bupivacaine, a commonly used aminoamide local anaesthetic, exerts cellular effects beyond anaesthesia. However, its effects on calcium (Ca2+) signalling and the physiological responses of lung fibroblasts remain insufficiently characterised...
METTL3-Mediated m6A Modification Facilitates pri-miR-221 Maturation to Regulate Macrophage M1/M2 Polarisation and Immune Inflammation in Rheumatoid Arthritis [0.03%]
METTL3介导的m6A修饰通过促进pri-miR-221成熟来调节类风湿关节炎巨噬细胞M1/M2极化及免疫炎症反应
Xiangping Gong,Wei Li,Xiaohui Wu et al.
Xiangping Gong et al.
Objective: Rheumatoid arthritis (RA) pathogenesis involves dysregulated macrophage polarisation, yet the epigenetic mechanisms governing this process remain poorly understood. This study investigates how METTL3 promotes p...
Bharangin, A Diterpenoid, Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine Through Involvement of Long Non-Coding RNAs and Nuclear Factor-κB [0.03%]
巴兰гин通过参与长链非编码RNA和核因子-κB提高胰腺癌细胞对吉西他滨敏感性
Nikee Awasthee,Anusmita Shekher,Ankit Srivastava et al.
Nikee Awasthee et al.
Pancreatic cancer (PaCa) manifests as an aggressive tumour due to the late occurrence of early symptoms. The overall 5-year survival rate of PaCa is merely 2%-9%. Bharangin (BG), a diterpenoid quinonemethide known for its anti-cancer activi...
COX17 Attenuates Diabetes-Associated Retinal Injury by Improving Mitochondrial Function [0.03%]
Cox17通过改善线粒体功能减轻糖尿病视网膜损伤
Hai-Yan Lian,Zhen-De Deng,Ming Yan et al.
Hai-Yan Lian et al.
Purpose: Diabetic retinopathy (DR), a common complication of diabetes, is a leading cause of blindness globally. Cytochrome C oxidase copper chaperone (COX17) is important for Cytochrome C oxidase assembly, and COX17 over...
Esculin Facilitates Aerobic Glycolysis via the Wnt/β-Catenin/HIF-1α Pathway to Reduce the Progression of Gastric Cancer [0.03%]
埃斯库拉汀通过Wnt/β-catenin/HIF-1α信号途径促进胃癌细胞的Warburg效应以抑制其进展
Qing Shang,Jing Wang,Xiaolei Wang et al.
Qing Shang et al.
Background: Gastric cancer (GC) is a complex pathogenesis closely related to various signalling pathways. Esculin, as a natural compound, possesses anti-oxidation, anti-inflammatory, and anti-tumour influences, and has sh...
METTL14 Inhibits Human Lung Microvascular Endothelial Cell From Ferroptosis in Septic Lung Injury by Regulating N6-Methyladenosine-Modified ACSL4 Level [0.03%]
METTL14通过调控N6-甲基腺苷修饰的ACSL4水平抑制脓毒症肺损伤中的人肺微血管内皮细胞发生铁死亡
Xiao Gui,Yongyang Tian,Haiyuan Zhu et al.
Xiao Gui et al.
Background: N6-methyladenosine (m6A) RNA modification is involved in numerous physiological and pathological processes. However, the specific role of m6A modification in septic lung injury remains unknown. ...
Apelin-13 Attenuates Right Ventricular Hypertrophy and Pulmonary Fibrosis in a Monocrotaline Model of Pulmonary Hypertension [0.03%]
阿皮林-13通过减少右心室肥大和肺纤维化治疗单端孢霉毒素所致肺动脉高压
Önder Öztürk,Rahime Aslankoc,Mustafa Saygın et al.
Önder Öztürk et al.
Pulmonary hypertension (PH) is a progressive and fatal disease characterised by pulmonary vascular remodelling, right ventricular hypertrophy, and increased pulmonary arterial pressure. Apelin, an endogenous ligand of the APJ receptor, exer...
Zihao Liu,Xiaoyu Wan,Anqi Li et al.
Zihao Liu et al.
Nontuberculous mycobacteria (NTM) infections, especially those caused by Mycobacterium abscessus, are extremely difficult to treat due to the organisms' intrinsic resistance to many antimicrobials. Myxin is a naturally occurring phenazine-5...
Dexmedetomidine Alleviates Sleep Rhythm Abnormalities in Chronic Sleep-Deprived Mice via Modulation of SIK3/HDAC4/5 Signalling [0.03%]
右美托咪啶通过调节SIK3/HDAC4/5信号通路缓解慢性睡眠剥夺小鼠的睡眠节律异常
Zhengye Wang,Yitong Ding,Yonghong Zhou et al.
Zhengye Wang et al.
Background: Sleep deprivation (SD) often disrupts normal sleep patterns, leading to anxiety-like behaviours and cognitive impairments. Dexmedetomidine (DEX), a highly selective α-2 adrenergic agonist, has been reported t...