Ellagic acid improves osteoarthritis by inhibiting PGE2 production in M1 macrophages via targeting PTGS2 [0.03%]
ellagic酸通过靶向PTGS2抑制M1型巨噬细胞中PGE2的产生从而改善骨关节炎
Chen Zhang,Xiaoke Li,Pengyuan Wen et al.
Chen Zhang et al.
Osteoarthritis (OA) is a degenerative joint disease characterised by inflammation and cartilage degeneration. Ellagic acid (EA) might have therapeutic potential in OA, but its molecular mechanisms of action remain unclear. In this study, we...
Attenuation of renal fibrosis in mice due to lack of bombesin receptor-activated protein homologue [0.03%]
由于缺少巴莫辛受体激活蛋白同源物所致的小鼠肾纤维化减轻
Zhi Peng,Hui Wang,Jiaoyun Zheng et al.
Zhi Peng et al.
Bombesin receptor-activated protein (BRAP), encoded by the C6orf89 gene in humans, is expressed in various cells with undefined functions. BC004004, the mouse homologue of C6orf89, has been shown to play a role in bleomycin-induced pulmonar...
Cancer-associated fibroblast-derived circFARP1 modulates non-small cell lung cancer invasion and metastasis through the circFARP1/miR-338-3p/SOX4 axis [0.03%]
癌相关成纤维细胞衍生的环状circFARP1通过circFARP1/miR-338-3p/SOX4轴调节非小细胞肺癌侵袭和转移
Wailong Zou,Yulin Li,Jia Zhang et al.
Wailong Zou et al.
The pleiotropic effect of cancer-associated fibroblasts (CAFs) on tumour progression depends on the environment. circFARP1 is critical for CAFs-induced gemcitabine (GEM) resistance in pancreatic cancer. Its specific role and mechanism in no...
Down-regulation of CYTL1 attenuates bleomycin-induced pulmonary fibrosis in mice by inhibiting M2 macrophage polarization via the TGF-β/CCN2 axis [0.03%]
CYTL1下调通过抑制TGF-β/CCN2轴诱导的M2型巨噬细胞极化减轻博来霉素致小鼠肺纤维化
Yan Wang,Chenxi Liu,Yi Xie et al.
Yan Wang et al.
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by chronic inflammation, lung tissue fibrotic changes and impaired lung function. Pulmonary fibrosis 's pathological process is thought to be influenced by ma...
Dihydromyricetin protects sevoflurane-induced mitochondrial dysfunction in HT22 hippocampal cells [0.03%]
双氢杨梅素通过保护异氟醚诱导的小鼠海马HT22神经元线粒体功能异常减少细胞凋亡
Xinyan Wang,Haoyi Li,Dongchao Qu
Xinyan Wang
Sevoflurane (Sev) is a commonly used inhalation anaesthetic that has been shown to cause hippocampus dysfunction through multiple underlying molecular processes, including mitochondrial malfunction, oxidative stress and inflammation. Dihydr...
Expression of Concern: High glucose facilitates cell cycle arrest of rat bone marrow multipotent adult progenitor cells through TGF-β1 and ERK1/2 signaling without change in Oct-4 expression [0.03%]
表达关注：高糖通过TGF- β1和ERK1 / 2信号转导途径而不改变Oct-4的表达促进大鼠骨髓多能成体祖细胞周期阻滞
M. Luo , Z. Liu , H. Hao , T. Lu , M. Chen , M. Lei , C.M. Verfaillie , and Z. Liu , "High Glucose Facilitates Cell Cycle Arrest of Rat Bone Marrow Multipotent Adult Progenitor Cells through Transforming Growth Factor-β1 and Extracellular ...
Oxycodone attenuates lipopolysaccharide-induced myocardial injury by inhibiting inflammation, oxidation and pyroptosis via Nrf2/HO-1 signalling pathway [0.03%]
吗啡酮通过Nrf2/HO-1信号途径抑制炎症、氧化和细胞焦亡减轻脂多糖诱导的心肌损伤
Yanting Wang,Wei Feng,Shaona Li et al.
Yanting Wang et al.
Myocardial injury and cardiovascular dysfunction are the most common complications of sepsis, and effective therapeutic candidate is still lacking. This study aims to investigate the protective effect of oxycodone in myocardial injury of li...
Quercetin-4'-O-β-D-glucopyranoside inhibits podocyte injury by SIRT5-mediated desuccinylation of NEK7 [0.03%]
槲皮素-4'-O-β-D- glucopyranoside通过SIRT5介导的NEK7脱琥珀酰化抑制足细胞损伤
Menghua Wu,Xiaoli Ye
Menghua Wu
Diabetic kidney disease (DKD) is a complication of diabetic mellitus. New treatments need to be developed. This study aimed to investigate the effects of quercetin-4'-O-β-D-glucopyranoside (QODG) on podocyte injury. Podocytes were cultured...
Comparison of disease-modifying anti-rheumatic drugs and hyperbaric oxygen therapy in the experimental model of rheumatoid arthritis in rats [0.03%]
大鼠类风湿关节炎模型中疾病修饰抗风湿药与高压氧治疗的比较研究
Mohamad Hallak,Ahmet Inal,Mehmet Akif Baktir et al.
Mohamad Hallak et al.
In this study, we wanted to investigate the effectiveness of combining disease-modifying anti-rheumatic drugs (DMARD) with hyperbaric oxygen therapy (HBOT) in reducing inflammation in a rheumatoid arthritis (RA) model using rats. We divided...
Establishment of diagnostic model and identification of diagnostic markers between liver cancer and cirrhosis based on multi-chip and machine learning [0.03%]
基于多芯片和机器学习建立肝癌与肝硬化鉴别诊断模型及发现分类标志物
Tianpeng Yang,Lu Huang,Jiale He et al.
Tianpeng Yang et al.
Objective: Most cases of hepatocellular carcinoma (HCC) arise as a consequence of cirrhosis. In this study, our objective is to construct a comprehensive diagnostic model that investigates the diagnostic markers distingui...