Phillygenin Inhibits PI3K-Akt-mTOR Signalling Pathway to Prevent bleomycin-Induced Idiopathic Pulmonary Fibrosis in Mice [0.03%]
Phillygenin通过抑制PI3K-Akt-mTOR信号途径防治博来霉素诱导的小鼠特发性肺纤维化
Yongjia Wei,Wenting Ni,Lizhi Zhao et al.
Yongjia Wei et al.
Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease characterised by irreversible lung structure and function. Phillygenin (PHI) is a lignan extracted from Forsythiae fructus with the activities of anti-inflammatory and antioxidant...
High Salt Exacerbates Myocardial Dysfunction In Vitro and In Vivo by Promoting SIRT1/Nrf2-Mediated Ferroptosis [0.03%]
高盐通过促进SIRT1/Nrf2介导的铁死亡加剧心肌功能障碍
Wu Guanji,Liu Fuqiang,You Fei et al.
Wu Guanji et al.
Myocardial dysfunction is a crucial determinant of the development of heart failure in salt-sensitive hypertension. Ferroptosis, a programmed iron-dependent cell death, has been increasingly recognised as an important contributor to the pat...
Inhibition of DNA Methyltransferase DNMT1 Reverses Th2 Response Polarisation and Alleviates Allergic Rhinitis [0.03%]
DNMT1酶抑制剂逆转Th2反应和缓解过敏性鼻炎
Peng Zou,Jianguo Li,Jia Li et al.
Peng Zou et al.
Background: Type 2 T helper (Th2) cells-mediated immune response plays vital roles in allergic rhinitis (AR), and DNA methylation is previously found to be closely related to AR development. ...
RETRACTION: Rotenone Restrains the Proliferation, Motility and Epithelial-Mesenchymal Transition of Colon Cancer Cells and the Tumourigenesis in Nude Mice via PI3K/AKT Pathway [0.03%]
撤稿：罗tenone通过PI3K / AKT途径抑制结直肠癌细胞的增殖，运动和上皮间质转化以及裸鼠的肿瘤生成
W. Xue, S. Men, and R. Liu, "Rotenone Restrains the Proliferation, Motility and Epithelial-Mesenchymal Transition of Colon Cancer Cells and the Tumourigenesis in Nude Mice via PI3K/AKT Pathway," Clinical and Experimental Pharmacology and Ph...
Retraction of Publication
Clinical and experimental pharmacology & physiology. 2025 Feb;52(2):e70014. DOI:10.1111/1440-1681.70014 2025
Oroxin B Resembles Bisoprolol in Attenuating Beta1-Adrenergic Receptor Autoantibody-Induced Atrial Remodelling via the PTEN/AKT/mTOR Signalling Pathway [0.03%]
Oroxin B通过PTEN/AKT/mTOR信号通路模仿Bisoprolol减轻β1肾上腺素受体自身抗体诱导的心房重构
Na Yang,Huaxin Sun,Linqiang Xi et al.
Na Yang et al.
Beta1-adrenergic receptor autoantibodies (β1-AAbs) promote atrial remodelling and ultimately lead to the development of atrial fibrillation (AF). Oroxin B is a natural flavonoid glycoside with a variety of biological activities, including ...
Fingolimod Inhibits C6 Rat Glioma Proliferation and Migration, Induces Sub-G1 Cell Cycle Arrest, Mitochondrial and Extrinsic Apoptosis In Vitro and Reduces Tumour Growth In Vivo [0.03%]
芬戈莫德抑制大鼠C6胶质瘤增殖和迁移，诱导细胞周期G1期阻滞、线粒体及外源性凋亡（体外），并减少体内肿瘤生长
Safura Pournajaf,Nastaran Afsordeh,Hadi Bayat et al.
Safura Pournajaf et al.
Glioblastoma multiforme (GBM), the most prevalent brain tumour, is universally fatal. GBM cells exhibit cell cycle disruption and treatment resistance, remarking an urgent need for newer treatments. Fingolimod, a sphingosine-1-phosphate rec...
Biochemical Investigation of the Association of Apolipoprotein E Gene Allele Variations with Insulin Resistance and Amyloid-β Aggregation in Cardiovascular Disease [0.03%]
APOE基因多态性与心血管病患者胰岛素抵抗及Aβ沉积的相关性生化研究
Komal Jabeen,Kanwal Rehman,Muhammad Sajid Hamid Akash et al.
Komal Jabeen et al.
This article investigates the intricate associations between apolipoprotein E (APOE) gene alleles variation, insulin resistance (IR) and amyloid-β aggregation in cardiovascular disease (CVD) patients. A cohort of 250 patients exhibiting th...
TLR4 Inhibitor TAK-242 Protected Henoch-Schonlein Purpura Nephritis in Rats by Regulating Inflammatory Response and Immune Competence via NF- κB/NLRP3 Signalling [0.03%]
TLR4抑制剂TAK-242通过NF-κB/NLRP3信号调节炎症反应和免疫 competence保护肾炎rats中的亨诺赫-许恩迪恩紫癜肾脏炎症反应和免疫胜任能力
Yirong Liu,Qiong Wu,Zhenxing Huang et al.
Yirong Liu et al.
This study aimed to explore the effect of toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB)/NOD-like receptor thermal protein domain-associated protein 3 (NLRP3) signalling on Henoch-Schonlein purpura nephritis (HSPN). We establis...
RETRACTION: Diosmetin Exerts Cardioprotective Effect on Myocardial Ischaemia Injury in Neonatal Rats by Decreasing Oxidative Stress and Myocardial Apoptosis [0.03%]
撤稿：二氢杨梅素通过降低氧化应激和心肌细胞凋亡对新生大鼠心肌缺血损伤发挥心脏保护作用
G. Mo, Y. He, X. Zhang, X. Lei and Q. Luo, "Diosmetin Exerts Cardioprotective Effect on Myocardial Ischaemia Injury in Neonatal Rats by Decreasing Oxidative Stress and Myocardial Apoptosis," Clinical and Experimental Pharmacology and Physio...
Retraction of Publication
Clinical and experimental pharmacology & physiology. 2025 Jan;52(1):e70009. DOI:10.1111/1440-1681.70009 2025
Trimetazidine restores autophagy via lncRNA H19/AMPK in diabetic heart: Implications for its therapeutic value against diabetic cardiomyopathy [0.03%]
曲美他嗪通过长链非编码RNA H19/AMPK途径恢复糖尿病心脏自噬：对治疗糖尿病心肌病的启示
Wei Wei,Yadi Hu,Jing Gao et al.
Wei Wei et al.
Objective: Previous studies have shown that trimetazidine (TMZ) alleviates diabetes-induced cardiac dysfunction. However, the underlying mechanism for its protective effects on cardiac function remains incompletely unders...