Pablo I Nikel
Pablo I Nikel
Metabolic engineering often treats microbial metabolism as an inventory of metabolites, reactions, and the enzymes that catalyze them. This Perspective argues that function emerges from metabolic architecture, the connectivities that bind r...
Tuneable Permeability of Cellulose Nanofibrils-based Membranes in Next-Generation Barrier-On-Chip Systems [0.03%]
基于纤维素纳米纤维的下一代片上屏障系统中的膜的可调透性
Vita Guarino,Johan Erlandsson,Elisa De Luca et al.
Vita Guarino et al.
Barriers in the human body play a crucial role in regulating the exchange of substances between compartments, with permeability alterations occurring under both physiological and pathological conditions. In vitro barrier models are essentia...
Advances in Electrochemical Biosensors for Circulating Tumor Cell Detection [0.03%]
电化学生物传感器检测循环肿瘤细胞的研究进展
Mengxiao Zhao,Mengqi Bai,Feiyi Zhang et al.
Mengxiao Zhao et al.
This review summarizes the latest advancements in electrochemical biosensors for the detection of circulating tumor cells (CTCs). As a core component of liquid biopsy, CTCs are highly valuable for tumor diagnosis and treatment. However, con...
Endogenous Labelling of Extracellular Vesicles and Image Capture of Their Interactions With Acceptor Cells [0.03%]
内源性细胞外囊泡标记及与受体细胞相互作用的影像捕获技术
Eden Booth,Massimiliano Garre,Dan Wu et al.
Eden Booth et al.
Despite their significance in both physiological and pathological contexts, the mechanisms governing extracellular vesicle (EV) uptake and cytosolic cargo delivery remain incompletely understood. Here, we report the development of a BF2-aza...
Ligand Electronics Dictate Geometry, Stability, and Cancer Cell Toxicity in Carbon-Stabilized Gold(III) Macrocycles [0.03%]
配体电子性质决定碳稳定金(III)大环的几何构象、稳定性及其抗癌细胞毒性
Justin C Holmes,Arinzechukwu Egwu,Sean Parkin et al.
Justin C Holmes et al.
Strategies for rationally designing gold-based chemotherapeutics remain limited by an incomplete understanding of how ligand electronics shape structure and biological function. Here, we establish a direct link between σ-donor strength, ge...
Droplet Microfluidics-Assisted Fabrication of Magnetite Nanoparticle Hybrid Microgels for Facile Protein Immobilization [0.03%]
一种用于简便固定蛋白的磁性纳米粒子杂化微凝胶的滴状微流控辅助制造法
Talika A Neuendorf,Anika Kaufmann,Russell J Wilson et al.
Talika A Neuendorf et al.
We introduce droplet microfluidics-fabricated hybrid microgels composed of biotinylated acrylamide that is crosslinked with N,N'-methylenebis(acrylamide). These microgels are further functionalized with streptavidin and loaded with magnetit...
A Bifunctional Protease Cleaves the Leader Peptide in the Biosynthesis of Class I Microviridins [0.03%]
具有双功能的蛋白酶在I类微孢子菌素生物合成中切割信号肽
Nico Brüssow,Stella Scholz,Antje Stindt et al.
Nico Brüssow et al.
Microviridins are a prominent family of highly potent serine protease inhibitors, of which individual variants specifically inhibit different types of proteases of pharmacological interest. These natural products of cyanobacterial origin be...
Radioiodination of Two Carborane-Based Dual Cyclooxygenase-2/5-Lipoxygenase Inhibitors and Their In Vitro and In Vivo Evaluation [0.03%]
两种基于碳硼烷的双环加氧酶-2/5-脂氧化酶抑制剂的放射性碘标记及其体外和体内评价
Jonas Schädlich,Martin Ullrich,Cathleen Haase-Kohn et al.
Jonas Schädlich et al.
Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) are key enzymes in prostanoid and leukotriene signaling and are overexpressed in various cancers, correlating with malignancy and metastasis. This renders them promising molecular targets f...
The Binding of 3-O-Methylfluorescein Phosphate to the Catalytic Domain of the Human CDC25B Phosphatase: A Structural Investigation [0.03%]
人CDC25B磷酸酶催化结构域与3-O-甲基荧光素焦磷酸酯的结合：结构研究
Romualdo Troisi,Rosario Rullo,Valeria Napolitano et al.
Romualdo Troisi et al.
The molecular mechanisms by which the human CDC25B activates the CDK1/cyclin B complex in the cell cycle, as well as how it can be inhibited by synthetic inhibitors at the atomic level, are still under investigation. Valuable insights have ...
NIR-I/II-Responsive Niosomes Co-Encapsulating Plasmonic Gold Nanorods and IR1061 for Phototherapeutic Ablation of Cancer Cells [0.03%]
基于尼奥索梅负载的贵金属纳米棒与近红外染料协同光疗肿瘤细胞的研究进展
Rishabh Kumar Srivastava,Shubham Kumar Singh,Antony Vincy et al.
Rishabh Kumar Srivastava et al.
Near-infrared (NIR) light-responsive nanomaterials have emerged as powerful tools for cancer therapy, yet stable and biocompatible delivery of NIR-II agents remains a major challenge. In this work, we develop NIR-I/II-responsive niosomes co...