Structure-Activity Relationship of Cyanine Dyes in Relation to the Hepatic Uptake and Excretion [0.03%]
与肝摄取和排泄有关的cyanine染料的结构活性关系研究
Nataliia S Berehova,Emily L J de Bock,Maarten P van Meerbeek et al.
Nataliia S Berehova et al.
Background: Indocyanine green (ICG) is a clinically approved fluorescent dye that is used for lesion identification during hepatobiliary surgery. However, the chemical structure of ICG seems to be suboptimal for this excr...
Fecal Material of Captive Wild Animals as Source of CAZymes With Application Potential [0.03%]
圈养野生动物粪便中的碳水化合物活性酶及其应用潜力
Julia Bechtner,Jiri Hosek,Clarissa Schwab
Julia Bechtner
Gastrointestinal systems of mammals and birds host taxonomically complex and functionally diverse microbial communities. Microbial activities contribute to community functioning and interaction with the host but can also be exploited as a s...
Accessing New Phenanthroline-Oxazine Scaffolds as Copper-Dependent DNA Damaging Probes [0.03%]
用于检测铜依赖性DNA损伤的新的菲立诺啉-氧氮杂缩合物探针的研究
Rebecca Lynn,Alex Gibney,Eva Delahunt et al.
Rebecca Lynn et al.
1,10-Phenanthroline (phen) is a versatile ligand commonly used in coordination chemistry, with particular interest in its ability to promote DNA binding and damage when coordinated with transition metals. Structural modifications of phen mo...
Zinc-Porphyrin Terephthalate-Based Metal-Organic Framework: Structural Insights and Functional Antibacterial Properties [0.03%]
基于锌-卟啉对苯二甲酸盐的金属有机骨架：结构洞察与功能抗菌性能
Kumar Shivam,Ritam Das,Manas K Panda et al.
Kumar Shivam et al.
Herein, we have synthesized the commonly known protonated 5,10,15,20-tetrakis(4-pyridyl)porphyrin (compound 1) and a mixed-linker zinc-based metal-organic framework (compound 2) and evaluated their antibacterial photodynamic therapy. The cr...
Sarah Melissa Strätker,Hartmut Kühn,R Martin Vabulas
Sarah Melissa Strätker
Peroxidation of polyunsaturated fatty acids in cellular membranes, when extensive and unrepaired, can lead to a form of eukaryotic cell death known as ferroptosis. A complex network of proteins and small molecules has evolved to modulate th...
Yongqing Ma,Yifeng Huang,Yuxuan Yan et al.
Yongqing Ma et al.
The 1,4-dihydropyridine (1,4-DHP) scaffold is a privileged scaffold in numerous therapeutic agents, including L-type calcium channel blockers, mineralocorticoid receptor antagonists, and calcitonin gene-related peptide receptor antagonists....
β-Mannosyl Triazoles as Mimics of Galactosyl Galectin-3 and Galectin-9 N-Terminal Domain Inhibitors [0.03%]
β-岩藻糖三氮唑模拟物作为半乳糖连接的Galectin-3和Galectin-9氨基末端结构域抑制剂
Fredrik Sjövall,Ulf J Nilsson
Fredrik Sjövall
Mannosyl β-C-1 amidotriazoles have previously been reported to have higher selectivity for galectin-9N (N-terminal domain) than the corresponding galactoside C3 amidotriazoles have, which were more selective for galectin-3. This study furt...
Controlled Modification of Axial Coordination of Single-Atom Nanozymes for Biomedical Applications [0.03%]
单原子纳米酶轴向配位的可控修饰及其生物医药应用
Xuejing Wang,Dongyang Li,Yunteng Qu
Xuejing Wang
Natural enzymes and traditional artificial enzyme mimics are limited in biomedical applications by high costs, instability, or insufficient structural complexity. Nanozymes address some issues but lack sophistication and clear structure-act...
A Streamlined Synthesis of Adenosine Vinylsulfonamide Probes for Aminoacyl-AMP Mimicry in NRPS [0.03%]
用于NRPS中氨基酰-AMP拟态的腺苷乙烯亚磺酰胺探针的精简合成法
Naoto Haraguchi,Arisa Suto,Takashi Matsui et al.
Naoto Haraguchi et al.
Adenosine vinylsulfonamide (AVS) probes provide a powerful means of stabilizing the thioesterification state in nonribosomal peptide synthetases (NRPSs) by mimicking aminoacyl-AMP intermediates. Existing synthetic strategies have enabled br...
Development of a Rhodamine-Based Chemosensor for Cd2+ Ions: A Combined Approach of Colorimetric, Fluorescent Detection, and Computational Modelling [0.03%]
用于Cd2+离子的罗丹明类化学传感器的发展：彩色、荧光检测和计算模型相结合的方法
Ram Kumar,Priya Takkar,Bholey Singh et al.
Ram Kumar et al.
This paper presents the design and synthesis of a new rhodamine-based Schiff base chemosensor (L) with exceptional selectivity and sensitivity for Cd2+. An analysis of L was conducted using various spectroscopic techniques, thereby validati...