Membrane Nanovesicle Systems for Delivery of Therapeutic Nucleic Acids to Glioblastoma [0.03%]
用于将治疗性核糖核酸递送至胶质母细胞瘤的膜纳 vesicle系统
Jae Young Park,Kangmin Park,Minhyung Lee
Jae Young Park
Glioblastoma is a devastating disease with a high mortality rate. Conventional therapies such as surgery, chemotherapy, and radiotherapy are used to treat it. However, the recurrence rate of glioblastoma is high, and the average lifespan, e...
Human Peripheral Myelin Protein 2 and Charcot-Marie-Tooth Disease or Structural Missense Variants Show Different Binding to Myelin-Like Lipid Monolayers [0.03%]
人外周神经髓鞘蛋白2和Charcot-Marie-Tooth疾病或结构错义变异体对类似髓鞘脂质单分子层的结合不同
Florian Arndt Schöffmann,Md Abdus Shukur Imran,Christian Schwieger et al.
Florian Arndt Schöffmann et al.
The peripheral myelin protein P2 (also known as PMP2/FABP8) has two basic functions in vivo: the transport of fatty acids within the cell to the target compartments and the adhesion of lipid bilayers in the peripheral nervous system myelin ...
High-Yield Expression of Arylmalonate Decarboxylase in Escherichia coli Through High-Cell-Density Cultivation Strategies [0.03%]
通过高细胞密度培养策略在大肠杆菌中高效表达芳香草酸脱羧酶
Jan Gerstenberger,Timm Werbilo,Robert Kourist et al.
Jan Gerstenberger et al.
This study develops and optimizes a high-cell-density cultivation (HCDC) of E. coli BL21 (DE3) to improve enzyme production utilizing DASGIP multibioreactor systems. By shifting from traditional shake flask methods to HCDC, we observed a 43...
Discovery of BI-10: An Unexplored Broad-Spectrum Antimicrobial Benzimidazole Derivative Targeting Bacterial Membrane [0.03%]
BI-10的发现：一种新的广谱抗菌苯并咪唑化合物及其对细菌细胞膜的作用机制研究
Biplab Sarkar,Rakshit Manhas,Arti Rathore et al.
Biplab Sarkar et al.
Antimicrobial resistance (AMR) has emerged as a global healthcare crisis, necessitating the discovery of potent antibacterial agents. In the present investigation, we report the discovery, in vitro and ex vivo antibacterial efficacy studies...
Binding Mode Analysis of Antifouling Compounds Targeting Tyrosinase and Acetylcholinesterase by Saturation Transfer Difference NMR Spectroscopy [0.03%]
饱和转移差分核磁共振技术研究防污化合物与酪氨酸酶及乙酰胆碱酯酶的结合模式
Ana Sara Gomes,Mariana Andrade,Diana I S P Resende et al.
Ana Sara Gomes et al.
Ecofriendly and sustainable antifouling (AF) compounds are required to replace toxic additives in maritime AF coatings. Our group has developed synthetic AF compounds with anti-settlement activity toward Mytilus galloprovincialis mussel wit...
Uracil-Peptide-Pyrene Conjugates as Cu2+-Sensitive Probes Targeting DNA, RNA, and Biorelevant Model Membranes [0.03%]
尿嘧啶-肽-吡rene缀合物作为铜离子敏感型探针靶向DNA，RNA及生物相关模型膜
Dijana Pavlović Saftić,Lucija Lulić Horvat,Ivo Piantanida
Dijana Pavlović Saftić
We report a series of uracil-triazole-pyrene peptidomimetics (2-4) designed to achieve modular geometric control through peptide linkers of varying length and flexibility. All three compounds exhibited submicromolar affinity for ds-DNA, whi...
Cy3-Conjugated Biocompatible Polymer Nanoparticles for Long-Term Mitochondrial Imaging [0.03%]
用于长期线粒体成像的 Cy3偶联生物相容性聚合物纳米粒子
Souma Kawashima,Mitsuo Inui,Izumi Takaba et al.
Souma Kawashima et al.
The cyanine dye Cy3 has recently gained attention as a membrane potential-responsive, small-molecule mitochondrial imaging probe. However, the efficiency of Cy3 for mitochondrial imaging is relatively low, as diffusion of Cy3 leads to stain...
Ultraviolet Raman Optical Activity as a Window Into Peptide Backbone Structure [0.03%]
紫外拉曼光学活性研究肽主链结构的新窗口
Ondřej Škrna,Josef Kapitán,Laurence D Barron et al.
Ondřej Škrna et al.
The spectroscopy of ultraviolet Raman optical activity (UV ROA) promises an excellent sensitivity to peptide and protein conformation, decoupling the backbone signal from most side chains. Compared to the more usual ROA with visible light, ...
Recent Advances in the Evolutionary Classification and Structural Insights of Hyaluronan Synthase [0.03%]
透明质酸合酶的进化分类及结构见解最新进展
Fulong Li,Yan Du,Nannan Li et al.
Fulong Li et al.
Hyaluronan synthase (HAS) is a membrane-bound enzyme with specific multifunctional glycosyltransferase activity that catalyzes the alternating addition of UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylglucosamine (UDP-GlcNAc) to synthesize...
Quantifying Ligand-to-Protein Distances in Complex Environments Using Intermolecular 19F PRE NMR Spectroscopy [0.03%]
利用分子间19F顺磁共振光谱量化复杂环境中配体至蛋白质的距离
Yannick Werle,Martha-Louise Inderfurth,Christopher J Lang et al.
Yannick Werle et al.
The determination of structural features is crucial to understand the interplay between structure and function of biomolecules and biomolecular complexes. In this context, nuclear magnetic resonance (NMR) spectroscopy provides experimental ...