Rational Design of a Multivalent RNA Combining Structural Motifs Tailored to Multiple Domains of Fused in Sarcoma for Potent Inhibition of Aggregation [0.03%]
一种理性的多价RNA的设计，结合针对融合位置癌蛋白多个域的结构基序以有效抑制聚集作用
Nobuaki Kuroiwa,Fumika Sakaue,Motoki Miura et al.
Nobuaki Kuroiwa et al.
Fused in sarcoma (FUS) is an RNA-binding protein whose pathological aggregation, driven by aberrant phase separation, is implicated in amyotrophic lateral sclerosis (ALS). Although RNA molecules can modulate the FUS phase behavior, identify...
Unspecific Peroxygenases-Catalyzed Oxidation of Pharmaceutical Compounds Considered Emerging Contaminants [0.03%]
非特异性过氧化物酶催化的药物化合物氧化反应用于新兴污染物的去除考察
Alina Torres-Aguirre,Azucena López-López,Mayra Avelar et al.
Alina Torres-Aguirre et al.
Unspecific peroxygenase (UPO) is versatile fungal enzyme that carries out with high efficiency a plethora of C-H oxyfunctionalizations of organic compounds, simply triggered by H2O2. With the goal of making UPO an industrial biocatalyst, it...
Use of Computational Models to Investigate Human Targets of Small Ubiquitous Molecules [0.03%]
计算模型在小泛素类分子作用人体目标研究中的应用
Elena Frasnetti,Francesco Frigerio,Fabrizio Cinquini et al.
Elena Frasnetti et al.
The effects on human health of chemical compounds, which might be present in the environment due to natural or anthropogenic causes, are a fundamental aspect to be considered for the protection of public health and workers' health and in th...
Ion- and Temperature-Programmable Reconfiguration of Subcompartments in Synthetic Cells [0.03%]
合成细胞中可编程的亚隔室重组现象
Zexi Xu,Petra Schwille
Zexi Xu
Spatial reorganization of subcompartments is a hallmark of living cells, enabling coordinated metabolism and signaling. Achieving dynamic reconfiguration remains a major challenge in synthetic cell design. Although specific ions play fundam...
Native Chemical Ligation at Phenylalanine via Ortho-Mercaptophenylalanine [0.03%]
通过邻巯基苯丙氨酸在酪氨酸处进行原生化学连接
Christina R Forbes,Brice A Ludwig,Glenn P A Yap et al.
Christina R Forbes et al.
Native chemical ligation (NCL) enables the synthesis of complex peptides and proteins. Prior work in NCL at phenylalanine (Phe) employed β-mercapto or β-seleno (alkyl) derivatives. Herein, we describe an alternative approach to NCL at Phe...
Antisense Oligonucleotide Releasing Cassette for Conditional Targeted RNA Degradation [0.03%]
用于条件性靶向RNA降解的反义寡核苷酸释放盒
Valeriia S Drozd,Muhammad S Anwar,Adeliia A Salimova et al.
Valeriia S Drozd et al.
Conventional single-stranded antisense oligonucleotides (ASOs) work by directly binding target mRNA, which limits their use to genes that need to be silenced without affecting healthy cells. To address this limitation and achieve conditiona...
Toward Sustainability: Intensification of Light-Driven Whole Cell Biocatalysis [0.03%]
迈向可持续性：强化光驱动全细胞生物催化作用
Lenny Malihan-Yap,Pablo Domínguez de Maria,Robert Kourist
Lenny Malihan-Yap
Photobiocatalysis with photoautotrophic whole cells has demonstrated strong potential for producing chiral molecules and platform chemicals using sustainable inputs such as light, water and CO2 under mild reaction conditions. Coupling enzym...
Multienzyme Platform for the Synthesis of UDP Sugars and Human Milk Oligosaccharides [0.03%]
用于合成尿苷二磷酸糖和人类乳汁低聚糖的多功能酶平台
Tuan Son Hoang,Fabian Lange,Sebastian Bruno Kleeberg et al.
Tuan Son Hoang et al.
Naturally occurring in breast milk, human milk oligosaccharides (HMOs) are of great interest as an ingredient for infant nutrition due to numerous associated health benefits. Current commercial production relies mainly on microbial fermenta...
Novel Multienzymatic Cascade for the Conversion of Salicin From Plant Extract Into Salicylic Acid [0.03%]
一种从植物提取物中将杨柳素转化为水杨酸的新型多酶级联反应
Amandine Moreno,Louis-Nicolas Gombault,Adrien Cottias et al.
Amandine Moreno et al.
This study presents a novel multienzymatic strategy for the efficient and green production of valuable salicylic acid from plant-derived salicin. The biocatalytic route couples β-glucosidase for deglycosylation with laccase and xanthine ox...
Investigation of the Linker-Length Preferences of Pantetheine Probes in the Cross-Linking Reactions Between Adenylation Enzymes and Carrier Proteins [0.03%]
泛肽探针连接臂长度对腺苷化酶与承载蛋白交联反应的偏好性研究
Iyo Arata,Kenji Nagata,Hakuto Miyoshi et al.
Iyo Arata et al.
Adenylation enzymes transfer acyl substrates selectively onto carrier proteins (CPs) in natural product biosynthesis. Despite the importance of adenylation enzyme-CP interactions, structural information on these transient complexes remains ...