The Design of Metal Ion-Induced Dimers Suggestive of 3D Domain Swapping [0.03%]
金属离子诱导的二聚体的设计，类似于三维结构域互换
Shota Shiga,Seiya Sugiyama,Satoshi Ito et al.
Shota Shiga et al.
Expanding strategies for the design of artificial protein dimers induced by metal ions is important for creating proteins with novel functions as well as useful research tools. In this study, we extended our previously established polyproli...
Detection of Diagnostic Antibodies in Immune-Mediated Diseases: A Focus on Antigens and Technologies [0.03%]
自身免疫病的诊断抗体检测：聚焦抗原和新技术
Silvia Bracci,Feliciana Real-Fernandez,Federico Pratesi et al.
Silvia Bracci et al.
Autoimmune diseases are conditions characterized by aberrant B-cell and T-cell reactivity against self-antigens. Autoantibodies are serological biomarkers of autoimmune diseases, as such, autoantibody testing is a key step for diagnosing an...
Estely J Carranza,Marie C Heffern,Dylan T Murray
Estely J Carranza
The intermediate filament (IF) protein vimentin is a critical component of the cell cytoskeleton, yet our mechanistic understanding of head and tail domain function is incomplete. The C-terminal tail domain of vimentin is of increasing inte...
Monoclonal Antibodies Accessing the Cytosol of Living Cells and Binding to Polo-Like Kinase 1 Interdomain Linker Affect Mitotic Behavior [0.03%]
单克隆抗体进入活细胞的细胞质并结合到极光激酶1结构域链接肽以影响有丝分裂行为
Clément Steyer,Jean-Christophe Amé,Mariel Donzeau et al.
Clément Steyer et al.
Polo-like kinase 1 (PLK1) is a master regulator of mitosis and a well-established driver of cancer progression. Strategies to target PLK1 have largely focused on RNA interference using small interfering RNAs or small-molecule inhibitors. He...
Assembly-Energetics-Control (AEC) Design Framework for Rotary DNA Nanomachines [0.03%]
用于旋转DNA纳米机器的装配-能量控制(AEC)设计框架
Xue-Yan Wang,Yicheng Heng,Julian A Tanner et al.
Xue-Yan Wang et al.
Rotary DNA nanomachines harness programmable DNA assemblies to mimic biological motors that drive cellular energy conversion and mechanical force transmission. With structural designs and actuation mechanisms growing ever more varied, the f...
Charge-Based Discrimination of Amyloids Using an Amyloid-Targeting Chemiluminescent Probe [0.03%]
基于电荷的淀粉样蛋白鉴别研究及靶向化学发光探针的应用
Jeewon Chung,R Erin Jessup,Jerry Yang
Jeewon Chung
Fluorescent probes have been widely developed for detecting amyloid biomarkers associated with neurodegenerative diseases (NDs). The requirement for external light for excitation, however, limits their utility for research and in vivo appli...
Bart Brouwer,Andy-Mark W H Thunnissen,Henriette J Rozeboom et al.
Bart Brouwer et al.
The development of artificial enzymes through incorporation of new-to-nature catalytic functionality into protein scaffolds has emerged as a powerful approach to expand the biocatalytic repertoire. Inspired by the success of Lactococcal mul...
Ficus carica Extract Loaded 3D-Printed Sodium Alginate/Guar Gum Scaffolds for Potential Wound Healing Applications: An In Vitro Study [0.03%]
一种体外研究：三维打印载有Ficus carica提取物的卡拉胶/藻酸盐支架用于潜在伤口治疗应用
Aima Ghouri,Muhammad Atiq Ur Rehman,Rizwan Ahmed Malik et al.
Aima Ghouri et al.
Skin burns are a major health concern that is caused by severe electric shocks, chemical and thermal exposure. The intense skin burns can cause the fibroblast cell death which can lead to the delayed wound healing. Direct ink write (DIW) pr...
Reconstitution of Archaeal Membrane Lipid Biosynthesis in Bacterial and Eukaryotic Hosts [0.03%]
在细菌和真核宿主中重建古菌膜脂生物合成路径
Wenzhuo Li,Yizhou Luo,Shizhe Zhang et al.
Wenzhuo Li et al.
The membrane lipids of archaea differ from those of bacteria and eukarya in backbone stereochemical configuration, chemical linkage type, and hydrophobic chain structure, a fundamental dichotomy termed the lipid divide. Synthetic biology an...
Identification of Secondary Nucleation Inhibitors of Amyloid-β Aggregation by Cellular Selection of a SICLOPPS Library [0.03%]
利用SICLOPPS文库的细胞筛选鉴定淀粉样蛋白-β聚集的二级成核抑制剂
ByungUk Lee,Brian Flood,Emma Potter et al.
ByungUk Lee et al.
Alzheimer's disease is characterized by the accumulation of amyloid beta (Aβ) aggregates. Soluble oligomers Aβ oligomeric intermediates (AβOs) generated during aggregation are hypothesized to be a neurotoxic species. Many cyclic peptides...