Luteolin Ameliorates Sepsis-Induced Acute Lung Injury by Targeting RPTPα to Reprogram Macrophage M1-M2 Polarization [0.03%]
Yang Chen,Si-Miao Yu,Ze-Kun Chen et al.
Yang Chen et al.
Dysregulated macrophage polarization is a critical pathological driver of sepsis-induced acute lung injury (ALI). However, the absence of novel therapeutic targets constitutes a significant translational barrier, underscoring the urgent nee...
Synthesis of Amines for Active Pharmaceutical Ingredients Using the Whole-Cell Factory Saccharomyces Cerevisae [0.03%]
利用整个细胞工厂酿酒酵母合成药物活性胺类化合物
Natalia Kwiatos,Stephen Ossel,Francesco G Mutti
Natalia Kwiatos
Whole-cell biocatalysis offers a sustainable alternative to traditional chemical synthesis for producing pharmaceutically relevant, often chiral, amines and amino acids. Saccharomyces cerevisiae has emerged as a privileged microbial chassis...
From Structure to Function: COX-Selective Anti-Inflammatory Activity of Cu(II) and Zn(II) Hydrazone Complexes [0.03%]
从结构到功能：铜(ii)和锌(ii)腙配合物的选择性环氧化酶抗炎活性研究
Ram Nayan Gautam,Riya Kumari,Diptee Mitra et al.
Ram Nayan Gautam et al.
Hydrazone-based ligands constitute multifunctional pharmacophores owing to their flexible coordination modes and tunable electronic properties. Upon metal complexation, these features modulate physicochemical characteristics and biological ...
Assessment of DNA Variations From Two In Vivo Skeletal Muscle Disorder Mouse Models Using Complementary Square-Wave Voltammetry and LC-MS/MS Analysis [0.03%]
基于互补方波伏安法和LC-MS/MS分析的两种体内肌肉骨骼疾病小鼠模型的DNA变异评估
Elizabeth R LaFave,Grayson B Sink,Saphal Bhandari et al.
Elizabeth R LaFave et al.
Duchenne Muscular Dystrophy (DMD) and Ehlers-Danlos Syndrome (EDS) are characterized by genetic instability due to DNA damage leading to loss of muscular function. Genetic impacts of these diseases were probed by extracting DNA from selecte...
Silanes to Silatranes: Robust Functionalization for Single-Molecule Force Spectroscopy [0.03%]
从硅烷到硅拉坦：单分子力谱的稳健功能化
Thomas D Courtney,Christopher B Hatchell,Xuliana O et al.
Thomas D Courtney et al.
Atomic force microscopy-based single-molecule force spectroscopy (SMFS) experiments require stable and reproducible functionalization of cantilevers and surfaces. Conventional silane-based methods suffer from poor stability, drastically hin...
Pyrazolyl-Pyridine Ruthenium Complexes: A New Metallic Line of Defense Against Acinetobacter baumannii [0.03%]
含吡啶并吡唑配体的金属配合物抗阿氏菌活性研究
M Cassiem Joseph,Sheldon Sookai,Monika Nowakowska et al.
M Cassiem Joseph et al.
The emergence of antimicrobial resistance (AMR), especially among ESKAPE infections, highlights the pressing necessity for novel chemical frameworks with atypical modes of action. Transition-metal complexes have emerged as attractive possib...
Silver-Doped PCL-Silk Fibroin Electrospun Nanofibrous Scaffolds with Synergistic Osteogenic and Antimicrobial Activity [0.03%]
具有协同骨诱导和抗菌活性的银掺杂PCL-桑蚕丝纤维素静电纺纳米纤维支架
Debolina Saha,Piyali Basak,Subhadip Bodhak
Debolina Saha
This study reports the fabrication and comprehensive characterizations of silver nanoparticles (AgNPs)-doped polycaprolactone-silk fibroin (PCL-SF) scaffolds designed to combine cytocompatibility with osteogenic and antibacterial functions ...
Silybin-Collagen XVII Composite Nanoemulsion for Enhanced Solubility, Skin Permeation, and Repair of UVB-Induced Skin Photodamage [0.03%]
白杨素-胶原XVII复合纳米乳液增强溶解度、皮肤渗透性和UVB引起的皮肤光损伤修复作用
Min Cheng,Jiajia Li,Xiaojing Li et al.
Min Cheng et al.
Excessive ultraviolet B (UVB) exposure causes oxidative stress, inflammation, barrier disruption, and premature skin aging. Silybin has antioxidant and anti-inflammatory activity but limited topical delivery because of poor aqueous solubili...
Impact of Two Small-Molecule Proteasome Stimulators on Cellular Growth and Metabolism [0.03%]
两种小分子蛋白酶体刺激剂对细胞增殖和代谢的影响
Kate A Kragness,Darci J Trader
Kate A Kragness
The proteasome degrades ubiquitinated proteins as well as intrinsically disordered proteins that can be processed independently of ubiquitin signaling. The 20S core particle (CP) plays a key role in the degradation of unstructured proteins....
Relationship Between Filament-Polymerizing Muscle Myosin and Droplets Generated by Liquid-Liquid Phase Separation [0.03%]
肌原纤维肌球蛋白与液-液相分离生成的无膜细胞器之间的关系
Tatsuyuki Waizumi,Mahito Kikumoto,Tomoharu Matsumoto et al.
Tatsuyuki Waizumi et al.
From individual living cells to the tissues and organs of multicellular organisms, the internal fluids contain numerous macromolecules such as nucleic acids and proteins. Liquid-liquid phase separation (LLPS) is proving to be useful in unde...