Increased CDKN2A expression correlates with resistance to platinum-based therapy and decreased infiltration of B lymphocytes in colon adenocarcinoma [0.03%]
CDKN2A表达水平的增加与结肠腺癌铂耐药及B淋巴细胞浸润减少有关
Ruru Gu,Shuai Li,Bin Yu et al.
Ruru Gu et al.
Background: Cuproptosis-related gene CDKN2A is involved in the development and progression of various solid tumors. However, the potential involvement of CDKN2A in colon adenocarcinoma (COAD) remains unexplored. ...
RNA G-quadruplexes: emerging regulators of gene expression and therapeutic targets [0.03%]
RNA G-四链体：基因表达调控因子及治疗靶点的新角色
Zukela Ruzi,Wei Zha,Huang Yuan Yuan et al.
Zukela Ruzi et al.
RNA G-quadruplexes (rG4s) are non-canonical, four-stranded secondary structures formed by guanine-rich RNA sequences. These dynamic elements have garnered significant attention for their critical roles in regulating gene expression, includi...
LncRNAs in hypoxic microenvironment; insight in their impact in cancer biology [0.03%]
缺氧微环境中的长链非编码RNA及其对癌症生物学的影响初探
Beena Briget Kuriakose,Ahmed Hjazi,Raed Obaid Saleh et al.
Beena Briget Kuriakose et al.
Hypoxia may facilitate metastasis and tumor advancement in solid tumors. Intratumoral hypoxia may facilitate tumor aggressiveness by stabilizing hypoxia-inducible factor-1α (HIF-1α). Various transcriptional and epigenetic pathways modulat...
Bioinformatics analysis and expression of the transcription factor MYC2 in Brassica napus in response to salt stress [0.03%]
盐胁迫下油菜转录因子MYC2的生物信息学分析及表达研究
Alireza Mirzaei,Jamshid Fooladi,Bahman Fazeli-Nasab et al.
Alireza Mirzaei et al.
Salt stress is a significant factor limiting plant growth and can severely reduce crop yields. In addition to causing physiological damage, salt stress disrupts the plant's internal balance and hinders nutrient absorption. However, plants h...
Advancing ornamental plant breeding through genomic technologies: opportunities, challenges, and future directions [0.03%]
基因组技术助力观赏植物育种：机遇、挑战与未来方向
Murshid Muhammed P K,Madhuri C Pagariya,Pritam R Jadhav et al.
Murshid Muhammed P K et al.
The ornamental plants constitute an important sector of horticulture industry, which are worth billions of dollars worldwide. There is a growing demand for new and improved cultivars and hence, breeders employ new tools and methods to addre...
Transcriptome analysis reveals no obvious unintended effects in the spleen of CRISPR/Cas9-mediated CD163 and pAPN double-knockout pigs [0.03%]
转录组分析揭示CRISPR/Cas9介导的CD163和pAPN双基因敲除猪脾脏中不存在明显的非预期效应
Zhi-Guo Liu,Nan Wang,Wan-Jie Wang et al.
Zhi-Guo Liu et al.
Gene editing provides powerful tools for farm animal breeding. Our group previously obtained CD163/pAPN double-knockout (DKO) pigs via CRISPR/Cas9 and somatic cell nuclear transfer. These pigs are not only resistant to three infectious viru...
Thermotolerance for yield and quality in rice: a novel NF-Ys-QT12 gene system [0.03%]
水稻高温抗性对产量和品质的影响：一个新的NF-Ys-QT12基因系统
Muhammad Abu Bakar Waqas
Muhammad Abu Bakar Waqas
With the increase in global temperatures, heat stress damaged the yield as well as grain quality of many cereal crops. Enhancing high temperature resistance in cereals have been remained a long sought objective. Li et al. recently published...
LRRC8A/PKC/FLNA pathway activation is detrimental to colon cancer patients [0.03%]
LRRC8A/PKC/FLNA信号通路激活对结直肠癌患者不利
Rong Liu,Lijuan Zhao,Shiyu Cui et al.
Rong Liu et al.
The volume-regulated anion channel (VRAC) is implicated in remodeling the cytoskeleton. Leucine-rich repeat-containing 8A (LRRC8A) serves as a critical constituent of VRAC; however, its interaction with the scaffolding protein FLNA has not ...
Exploring the m5C epitranscriptome of mRNAs in breast cancer cells through genome engineering and long-read sequencing approaches [0.03%]
借助基因组编辑和长读测序技术探索乳腺癌细胞中mRNA的m5C表转录组
Konstantina Athanasopoulou,Panagiotis G Adamopoulos,Panagiotis Tsiakanikas et al.
Konstantina Athanasopoulou et al.
Epitranscriptomics has emerged as a rapidly evolving field that focused on studying post-transcriptional RNA modifications and their role in spatiotemporal regulation of gene expression. N6-methyladenosine (m6A) and 5-methylcytosine (m5C) r...
Breaking the palatability trade-off: idealizing resistant starch in rice [0.03%]
突破适口性限制：大米抗性淀粉的理想化研究
Tilak Chandra,Sarika Jaiswal,Mir Asif Iquebal et al.
Tilak Chandra et al.
A recent study by Sang et al. successfully demonstrated the simultaneous editing of SBEIIb to develop rice germplasm with an enhanced resistant starch composition, without compromising palatability. This research reveals the unique advantag...