HJURP upregulation, driven by transcription factor NFYA, promotes endometrial carcinoma progression via regulating RASSF8 ubiquitination [0.03%]
转录因子NFYA诱导HJURP上调通过调控RASSF8泛素化促进子宫内膜癌进展
Meng Jiang,Xinyu Xu,Yue Gao et al.
Meng Jiang et al.
Endometrial carcinoma (EC) is the most common malignant gynecological cancer with high mortality. Holliday junction recognition protein (HJURP), an E3 ubiquitin ligase dysregulated in various malignancies, has an unclear role in EC. We asse...
Analysis of differential gene expression in potato leaves exposed to low dose ionizing radiation [0.03%]
低剂量电离辐射处理对马铃薯叶片差异基因表达分析
Yongil Yang,Robert G Sears,Brianna Jacobs et al.
Yongil Yang et al.
Land plants demonstrate high tolerance to acute ionizing radiation compared to other metazoans. However, few studies have analyzed plant gene expression in response to low-dose ionizing radiation. The present study performed two different s...
Integrative multi-omics analysis and machine learning identify M2 macrophage-induced ferroptosis resistance in glioblastoma [0.03%]
整合多组学分析和机器学习识别胶质母细胞瘤中M2型巨噬细胞引起的铁死亡抵抗性
Fangzhou Guo,Teng Deng,Jun Yan et al.
Fangzhou Guo et al.
Glioblastoma (GBM) is characterized by profound intratumoral heterogeneity and an immunosuppressive microenvironment that drive therapeutic resistance and poor prognosis. While both tumor-associated macrophages (TAMs) and ferroptosis have b...
Deciphering the potential molecular network underlying nicotine- and its metabolite cotinine-induced myocardial infarction via network toxicology, molecular dynamics, and in vitro experimental validation [0.03%]
基于网络毒理学、分子动力学及体外实验验证解析尼古丁及其代谢产物可替宁诱导心肌梗死的潜在分子网络机制
Yang Fu,Chen Liu,Lifang Su
Yang Fu
Smoking is a major modifiable risk factor for myocardial infarction (MI); however, the molecular mechanisms through which its core component nicotine and its primary metabolite cotinine mediate MI development remain incompletely understood....
Isolation and characterization of Enterococcus phages vB_EfaS_785CC and vB_EfaS_785CS [0.03%]
肠球菌噬菌体vB_EfaS_785CC和vB_EfaS_785CS的分离与鉴定
Shixuan Huang,Yangkai Li,Zekun Liu et al.
Shixuan Huang et al.
Phage therapy offers a promising alternative to antibiotics, with lysin capacity being a key determinant of therapeutic efficacy. This study isolated two Enterococcus faecalis phages, vB_EfaS_785CC and vB_EfaS_785CS, from aquatic market sew...
MO-IPS suppresses acute myeloid leukemia through metabolic reprogramming and synergizes with anti-PD-1 immunotherapy [0.03%]
MO-IPS通过代谢重编程抑制急性髓系白血病并协同抗PD-1免疫治疗
Yingwen Wang,Wenjun Zhao,Yanrui Jin et al.
Yingwen Wang et al.
Our prior research identified MO-IPS as a potent MYC-PRMT inhibitor. Here, we re-evaluated its efficacy at optimized lower doses to explore a wider therapeutic window. MO-IPS retained robust anti-proliferative activity in vitro at reduced e...
Multi-omics analysis positions DNA2 at the interface of genome integrity programs and tumor behavior in pan-cancer [0.03%]
泛癌症中的多组学分析将DNA2定位在基因组完整性方案和肿瘤行为的交界处
Depanshi Pandit,Amardeep Dhillon,Sanjiban Chakrabarty et al.
Depanshi Pandit et al.
DNA2 coordinates essential maintenance processes, including cell-cycle progression; however, its aberrant activity has been implicated in cancer cell survival under oncogene-induced replication stress. To date, no comprehensive pan-cancer i...
Lipid-lowering activity of mulberry seed unsaturated fatty acids: integrating network pharmacology and experimental validation [0.03%]
桑籽不饱和脂肪酸降脂作用的网络药理及实验验证
Yue Zhang,Haoran Huang,Jianglong He et al.
Yue Zhang et al.
According to gas chromatography-mass spectrometry (GC-MS) analysis, mulberry seed oil (MSO) contains a high proportion of unsaturated fatty acids, accounting for 88.26% of its total composition. Although unsaturated fatty acids are reported...
DLEU2 promotes the migration and invasion of papillary thyroid carcinoma cells through the ELAVL1/RCC2 axis [0.03%]
DLEU2通过ELAVL1/RCC2轴促进乳头状甲状腺癌细胞的迁移和侵袭
Suwei Zuo,Sinuo Sun,Yuanyuan Wang et al.
Suwei Zuo et al.
Among the various histological types of thyroid cancer (TC), papillary thyroid carcinoma (PTC) is highly prevalent. Studies conducted in the past have revealed that the LncRNA DLEU2 is aberrantly expressed in PTC and is relevant to tumorige...
Detoxification mechanisms of black soldier fly larvae against microcystin-LR [0.03%]
黑固丽蝇幼虫解毒机制对抗微囊藻毒素-LR
Wenna Bao,Xinying Li,Haifeng Pan et al.
Wenna Bao et al.
This study aimed to elucidate the detoxification mechanisms of black soldier fly larvae (BSFL) against microcystin-LR (MC-LR). Using concentration-gradient exposure (0 - 400 µg/L) and integrated metagenomic and transcriptomic analyses, we ...