Integration of scRNA-seq and bulk tissue RNA-seq data to identify cancer-associated fibroblast-related gene RGMA as a potential treatment target for esophageal cancer [0.03%]
整合scRNA-seq和批量组织RNA-seq数据，以识别癌症相关成纤维细胞相关的基因RGMA作为治疗食管癌的潜在靶点
Yanqing Gao,Shuguang Bao,Bao Wen et al.
Yanqing Gao et al.
Cancer-associated fibroblasts (CAFs) serve as key stromal components within tumor microenvironment (TME), playing a significant role in the development and outcome of esophageal cancer (EC). There is an urgent need to identify genes related...
USP6NL knockdown suppresses colorectal cancer progression by inducing CASP9-Mediated apoptosis and disrupting FOXC2/SNAI1-Driven EMT and angiogenesis [0.03%]
USP6NL敲低通过诱导CASP9介导的细胞凋亡并干扰FOXC2 / SNAI1驱动的EMT和血管生成来抑制结直肠癌进展
Mohammed Ahmed Mohammed,Ahmed Abdelmagied Soffar,Amany I Yousef et al.
Mohammed Ahmed Mohammed et al.
Background: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with tumor progression often driven by dysregulated oncogenic pathways. USP6NL, a known regulator of endocytic trafficking...
Genome-wide characterization of invertases in Arabica coffee and its progenitors reveals putative genes involved in fruit development [0.03%]
阿拉伯咖啡及其祖先的转化酶基因组特征分析揭示了参与果实发育的候选基因
Gabriela Ester Ferraz,Robert Márquez Gutiérrez,Tiago Yukio Inoue et al.
Gabriela Ester Ferraz et al.
In plant physiological processes, invertases act by irreversibly degrading sucrose into hexoses, which actively contribute to plant growth and development. Few invertase genes have been characterized in Coffea, and consequently, the role of...
SPP1 promotes malignant characteristics and drug resistance in hepatocellular carcinoma by activating fatty acid metabolic pathway [0.03%]
SPP1通过激活脂肪酸代谢途径促进肝癌恶性表型及耐药性
Zhijiang Wang,Chengfang Wang
Zhijiang Wang
Hepatocellular carcinoma (HCC) progression and prognosis are influenced by various molecular markers. This study aimed to identify the hub gene associated with HCC clinical characteristics and its role in HCC progression. Differentially exp...
Efficient gene editing of BMP15, GDF9, and MSTN-but not the imprinted CLPG gene-in goat embryos via electrotransfection and handmade cloning [0.03%]
电穿孔和手工克隆在山羊胚胎中高效编辑BMP15、GDF9、MSTN基因而非 imprint CLPG基因
Mehdi Hajian,Ahmad Pirali,Seyed Hossein Hosseini Moghaddam et al.
Mehdi Hajian et al.
CRISPR/Cas9 technology represents a powerful tool for advancing livestock breeding by enabling precise, on-target gene edits without the genomic mixing associated with traditional introgression methods. In this study, we employed a dual gRN...
Integrated Nanopore and short-read RNA sequencing identifies dysregulation of METTL3- m6A modifications in endocrine therapy- sensitive and resistant breast cancer cells [0.03%]
整合型纳米孔和短读长RNA测序识别内分泌治疗敏感性和耐药性乳腺癌细胞中METTL3-m6A修饰失调
Belinda J Petri,Kellianne M Piell,Bailey L Avila-Valdes et al.
Belinda J Petri et al.
The role of epitranscriptomic changes in the development of acquired endocrine therapy (ET)- resistance in estrogen receptor α (ER) expressing breast cancer (BC) is unknown. We tested the hypothesis that inhibition of METTL3, the methyltra...
Immune-based molecular subtyping of triple-negative breast cancer via SNF-CC and functional validation of key immune-associated genes [0.03%]
基于免疫的三阴性乳腺癌分子亚型分类及关键免疫相关基因的功能验证
Pengwei Guo,Fengfei Yan,Hui Chang et al.
Pengwei Guo et al.
Triple-negative breast cancer (TNBC) presents significant therapeutic challenges due to its aggressive nature and lack of targeted treatment options. Emerging evidence highlights the critical role of immune infiltration patterns in TNBC pro...
iACP-DPNet: a dual-pooling causal dilated convolutional network for interpretable anticancer peptide identification [0.03%]
基于因果膨胀卷积的双池化网络用于抗癌肽识别及其可解释性研究
Zimeng Zhang,Xin Wang,Wenhui Shang
Zimeng Zhang
Anticancer peptides (ACPs) are acknowledged for their potential in cancer therapy, attributed to their safety, low side effects, and high target specificity. However, the discovery of ACPs is slowed by the high cost and labor-intensive natu...
Retraction Note: Xihuang pill facilitates glioma cell pyroptosis via the POU4F1/STAT3 axis [0.03%]
撤回 notice:西黄丸通过POU4F1/STAT3轴促进胶质瘤细胞焦亡
Ning Tang,Yuanyuan Zhu,Jianbai Yu
Ning Tang
Discovering novel type I collagen fragments from Cyprinus carpio supporting bone regeneration [0.03%]
来源于鲤鱼的I型胶原蛋白肽促进骨再生作用及其机制研究
Jianhua Zeng,Miao Chen,Xinglong Wang et al.
Jianhua Zeng et al.
Fish collagen is gaining increasing attention in tissue engineering due to its exceptional bioactivity. This study aimed to isolate functional fish collagen fragments capable of microbial biosynthesis and supporting bone tissue regeneration...