Pan-cancer single-cell and spatial transcriptomics implicate cancer-associated fibroblasts in neutrophil immunosuppressive phenotypic transitions and immunotherapy resistance [0.03%]
泛癌单细胞和空间转录组学揭示癌症相关成纤维细胞在中性粒细胞免疫抑制表型转化和免疫治疗耐药中的作用
Zhiyu Guo,Xujia Li,Lingli Huang et al.
Zhiyu Guo et al.
Neutrophils are the most abundant granulocyte population and have important functions such as defense against pathogens. However, they show significant Heterogeneity and play more complex roles in tumors. The theory of two-tiered differenti...
Switching on survival: how rice outsmarts heat with a natural gene circuit [0.03%]
破解生存之道：水稻利用天然基因回路智胜高温
Mohammad Abubakar Yasin,Muhammad Waseem Sajjad,Rubab Zahra Naqvi et al.
Mohammad Abubakar Yasin et al.
Globally, the important economic and staple food crops face various abiotic and biotic factors that influence their growth and yield. Traditional breeding strategies have attempted to improve heat tolerance, but often face challenges as imp...
Hypoxia-induced S100A10 promotes glioblastoma malignancy and chemoresistance by activating PI3K-AKT signaling pathway [0.03%]
缺氧诱导的S100A10通过激活PI3K-AKT信号通路促进胶质母细胞瘤恶性进展及耐药性
Qingqing Yang,Yunlan Xi,Xuewei Huang et al.
Qingqing Yang et al.
Glioblastoma (GBM) is the most frequent and lethal subtype of glioma that leads to unsatisfactory clinical outcomes. Hypoxia-induced chemoresistance exacerbates therapy. S100 calcium-binding protein A10 (S100A10) plays a crucial role in the...
Genome-wide identification and analysis of paclobutrazol-resistance gene family in cotton and the positive role of GhPRE3 in salt stress and drought stress resistance [0.03%]
基于全基因组鉴定棉花paclobutrazol抗性基因家族及GhPRE3正向调控耐盐和抗旱研究
Shuaikang Geng,Jingjing Zhai,Bingkai Cui et al.
Shuaikang Geng et al.
Cancer gene therapy: historical perspectives, current applications, and future directions [0.03%]
癌症基因治疗：历史回顾、当前应用和未来方向
Jingyi Zeng,Jingwen Luo,Yingchun Zeng
Jingyi Zeng
Gene therapy has emerged as a transformative approach in cancer treatment, leveraging genetic modifications to target malignancies with enhanced precision. Early efforts faced challenges such as inefficient vector delivery (< 5% tumor trans...
Dissecting the genomic landscape of ERD genes in alfalfa (Medicago sativa): the effect of melatonin and low selenium under salt stress [0.03%]
盐胁迫下白三叶草（Medicago sativa）ERD基因组景观的解构：褪黑素和低硒的影响
Muslim Qadir,Farhan Nabi,Jiaqin Shi et al.
Muslim Qadir et al.
The early response to dehydration (ERD) gene family plays a central role in abiotic stress regulation, plant development and defense mechanisms, particularly under dehydration conditions. However, the genomic characterization and functional...
Multi-omics based consensus subtypes, development of prognostic signature, and identification of INHBB as a potential therapeutic target in colorectal cancer [0.03%]
基于多组学的共识亚型、预后特征谱的开发以及在结直肠癌中将INHBB识别为潜在治疗靶点
Xu Wang,Yuanmin Xu,Rui Sun et al.
Xu Wang et al.
This study aims to refine molecular subtypes via multi-omics data, develop a prognostic signature, and identify novel biomarkers in colorectal cancer (CRC). On the basis of the multi-omics data, the MOVICS R package was used to divide patie...
Joint multi-omics analysis reveals the response mechanism in rapeseed (Brassica Rapa L.) under low nitrogen stress [0.03%]
联合多组学分析揭示了低氮胁迫下油菜（Brassica Rapa L.）的响应机制
Yi Gong,Fang Huan,Saba Zafar et al.
Yi Gong et al.
Nitrogen is fundamental macronutrient that regulates plant growth by modulating a wide array of physiological and metabolic processes. However, the excessive application of nitrogen fertilizers has led to substantial environmental concerns,...
Udita Basu,Swarup K Parida
Udita Basu
Advancements in translational genomics have revolutionized crop breeding, driving us from traditional breeding methods towards next-generation strategies that integrate genomic, transcriptomic, and phenotypic data to expedite crop improveme...
Comprehensive evolutionary, differential expression and VIGS analyses reveal the function of GhNST1 in regulating drought tolerance and early maturity in upland cotton [0.03%]
全面的进化、差异表达和VIGS分析揭示了GhNST1在调节陆地棉干旱耐受性和早熟性中的功能
Xueli Zhang,Dandan Li,Xuefeng Guo et al.
Xueli Zhang et al.
NAC secondary wall thickening promoting factor 1 (NST1) is crucial for abiotic stress responses and plant growth and development. However, the study of the function of GhNST1 in upland cotton is rather limited. Our study revealed that its p...